Evaluation of the Inhibitory Activities of COVID‐19 of <i>Melaleuca cajuputi</i> Oil Using Docking Simulation

My, Tran Thi Ai; Loan, Huynh Thi Phuong; Hai, Nguyen Thi Thanh; Hiếu, Lê Trung; Tran, Thai-Hoa; Thuý, Bùi Thị Phương; Quang, Duong Tuan; Triet, Nguyen Thanh; Anh, Trần Thị Vân; Dieu, Nguyen Thi Xuan; Trung, Nguyễn Tiến; Hue, N. V.; Tất, Phạm Văn; Tùng, Võ Thanh; Nhung, Nguyen Thi Ai

doi:10.1002/slct.202000822

Cited by 44 publications

(32 citation statements)

References 23 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The identified components represented 93.1–99.3 % of the total detected areas under the GC peaks. Speaking in terms of the previous studies of their chemical composition, all of the essential oils displayed typical chemical profiles for the plant species, i. e., they corresponded well to those published: C. bergamia , [11,12] C. sempervirens , [13,14] C. winterianus , [15,16] E. globulus , [17,18] E. smithii , [19,20] M. cajuputi , [21,22] M. piperita , [23,24] M. fragrans , [25,26] M. communis , [27,28] P. mugo , [29,30] P. niger , [31,32] P. sylvestris , [33,34] and R. officinalis [35] . The majority of the major components were oxygenated monoterpenes with demonstrated antimicrobial effect, known to contribute favorably to the aroma of a mouthwash, such as 1,8‐cineole, menthol, linalool and related derivatives [36] .…”

Section: Resultssupporting

confidence: 72%

Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies

Filipović

Stevanović

Stojanović-Radić

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

Thirteen commercial essential oils were assessed for their possible inclusion in a mouthwash formulation based on their inhibitory effect against potentially pathogenic anaerobic oral bacterial isolates from subgingival plaque, and their cytotoxicity towards gingival cells. The essential oils, originating from species belonging to seven major aromatic plant families, were chosen to provide the necessary diversity in chemical composition that was analyzed in detail by GC and GC/MS. Multivariate statistical analysis, performed using the in vitro microbiological/toxicological assays and compositional data, revealed that the major components of the essential oils were probably not the main carriers of the activities observed. A formulation of 'designer' mouthwashes is proposed based on the selective action of certain essential oils towards specific bacterial isolates (e. g., Citrus bergamia vs. Parvimonas micra), and non-toxicity to gingival cells at antimicrobially active concentrations.

show abstract

Section: Resultssupporting

confidence: 72%

Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies

Filipović

Stevanović

Stojanović-Radić

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…1,8-Cineole is abundantly present in eucalyptus plants and is an effective treatment for pediculosis [ 15 ], as well as an efficient biological herbicide [ 16 ], antimicrobial, and antioxidant [ 17 ]. Recently, several essential oil-derived components, such as 1,8-cineole, have been reported to inhibit influenza symptoms [ 18 ] and severity of coronavirus disease 2019 (COVID-19) [ 19 , 20 , 21 ]. Furthermore, some researchers are also investigating using 1,8-cineole as a new treatment for COVID-19 symptoms [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Chemical Composition between Kuromoji (Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect

et al. 2020

View full text Add to dashboard Cite

Kuromoji (Lindera umbellata) is a tree that grows throughout Japan. The components of kuromoji essential oil have antitumor and aromatherapy effects. However, the composition of the hydrosol, obtained as a by-product of the essential oil process, is unknown. Furthermore, it is unknown whether kuromoji essential oil has a deodorizing effect. Therefore, the purpose of the current study was to compare the chemical composition of kuromoji essential oil and hydrosol, as well as evaluate the deodorizing effect of the former. The chemical composition of samples was evaluated using gas chromatography–mass spectrometry (GC-MS). Additionally, the deodorizing effect of Kuromoji essential oil was investigated with the detector tube method using ammonia, hydrogen sulfide, methyl mercaptan, and isovaleric acid. Linalool was the most abundant component in both the essential oil and hydrosol; however, its proportion was higher in the hydrosol (57.5%) than in the essential oil (42.8%). The hydrosol contained fewer chemical components, but higher proportions of trans-geraniol and ethanol. Moreover, the essential oil eliminated 50% of ammonia and 97.6% or more of isovaleric acid. Interestingly, linalool was soluble in the hydrosol and did not irritate the skin. This suggests that the hydrosol may be an effective foot care product.

show abstract

“…In-silico studies were also performed on natural compounds that are readily available in onion, garlic, ginger, peppermint, and fenugreek [ 149 , 150 ]. The computational results pointed out leucopelargonidin and aronadendin are promising Mpro inhibitors, while 5S-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone , contained in Ginger, interacted with the SARS-CoV-2 Spike protein [ 111 , 132 ].…”

Section: Resultsmentioning

confidence: 99%

Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets

et al. 2021

View full text Add to dashboard Cite

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified in China as the etiologic agent of the recent COVID-19 pandemic outbreak. Due to its high transmissibility, this virus quickly spread throughout the world, causing considerable health issues. The scientific community exerted noteworthy efforts to obtain therapeutic solutions for COVID-19, and new scientific networks were constituted. No certified drugs to efficiently inhibit the virus were identified, and the development of de-novo medicines requires approximately ten years of research. Therefore, the repurposing of natural products could be an effective strategy to handle SARS-CoV-2 infection. This review aims to update on current status of the natural occurring compounds recognizing SARS-CoV-2 druggable targets. Among the clinical trials actually recruited, some natural compounds are ongoing to examine their potential role to prevent and to treat the COVID-19 infection. Many natural scaffolds, including alkaloids, terpenes, flavonoids, and benzoquinones, were investigated by in-silico, in-vitro, and in-vivo approaches. Despite the large data set obtained by a computational approach, experimental evidences in most cases are not available. To fill this gap, further efforts to validate these results are required. We believe that an accurate investigation of naturally occurring compounds may provide insights for the potential treatment of COVID-19 patients.

show abstract

Evaluation of the Inhibitory Activities of COVID‐19 of Melaleuca cajuputi Oil Using Docking Simulation

Cited by 44 publications

References 23 publications

Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies

Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies

Comparison of Chemical Composition between Kuromoji (Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect

Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets

Contact Info

Product

Resources

About