Evaluation of the influence of age and gender on the relationships between infarct size, infarct severity, and left ventricular ejection fraction in patients successfully treated with primary percutaneous coronary intervention

Sciagrà, Roberto; Parodi, Guido; Migliorini, Angela; Memisha, Gentian; Antoniucci, David; Pupi, Alberto

doi:10.1007/s12350-010-9213-7

Cited by 5 publications

(4 citation statements)

References 32 publications

(47 reference statements)

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“…Both Gevaert et al and Sederholm Lawesson et al showed that female gender was independently associated with renal dysfunction at admission in PCI‐treated patients. Furthermore, Sciagra et al showed that among 460 patients with acute myocardial infarction, there was a significant gender‐related difference with left ventricular ejection fraction decreasing more sharply in females than in males. The higher rate of complications can also be explained by the higher baseline risk factors.…”

Section: Discussionmentioning

confidence: 99%

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Laufer‐Perl

Shacham

Letourneau-Shesaf

et al. 2015

Clinical Cardiology

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Background:The increased mortality related to female gender in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) has been reported from various patient cohorts and treatment strategies with controversial results. In the present work, we evaluated the impact of female gender on mortality and in-hospital complications among a specific subset of consecutive STEMI patients managed solely by PPCI. Hypothesis: Female gender is not an independent predicor for mortality among STEMI patients. Methods: We performed a retrospective, single-center observational study that included 1346 consecutive STEMI patients undergoing PPCI, of which 1075 (80%) were male. Patient's records were evaluated for 30-day mortality, in-hospital complications, and long-term mortality over a mean period of 2.7 ± 1.6 years. Results: Compared with males, females were older (69 ± 13 vs 60 ± 13 years, P < 0.001), had a significantly higher rate of baseline risk factors, and had prolonged symptom duration (460 ± 815 minutes vs 367 ± 596 minutes, P = 0.03). Females suffered from more in-hospital complications and had higher 30-day mortality (5% vs 2%, P = 0.008) as well as higher overall mortality (12.5% vs 6%, P < 0.001). In spite of the significant mortality risk in unadjusted models, a multivariate adjusted Cox regression model did not demonstrate that female gender was an independent predictor for mortality among STEMI patients. Conclusions: Among patients with STEMI treated by PPCI, female gender is associated with a higher 30-day mortality and complications rates compared to males. Following multivariate analysis, female gender was not a significant predictor of long-term death following STEMI.

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Section: Discussionmentioning

confidence: 99%

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Laufer‐Perl

Shacham

Letourneau-Shesaf

et al. 2015

Clinical Cardiology

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“…First, the study was retrospective and involved a small number of patients with perfusion abnormalities. Second, several studies evaluated the impact of age and gender on the relationship between LVEF and clinical outcomes [35,36]. We did not take such a point into account in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Left Ventricular Ejection Fraction by Thallium-201 Myocardial SPECT-CT in Patients with Angina Pectoris: Comparison with 2D Echocardiography

Kim

Park

Kim

et al. 2019

Nucl Med Mol Imaging

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Purpose Left ventricular (LV) ejection fraction (EF) is an important parameter for assessing cardiac systolic function and predicting prognosis in patients with cardiovascular disease. The aim of this study was to evaluate the feasibility of assessing LVEF by Tl-201 hybrid myocardial single-photon emission computed tomography (SPECT)/CT using two attenuation correction methods in patients with angina pectoris. Methods A total of 339 patients with angina pectoris (62.8 ± 12.9 years, male:female = 206:133) were analyzed. All patients underwent Tl-201 myocardial SPECT/CT and transthoracic two-dimensional (2D) echocardiograph. We compared LVEF assessed by SPECT/CT using two attenuation correction methods: CT-based attenuation correction (CTAC) and nonattenuation correction (non-AC) methods and 2D echocardiography. Results LVEF assessed by either of the two attenuation correction techniques and 2D echocardiography showed moderate correlation in all patients with angina pectoris (r = 0.487 for CTAC and r = 0.473 for non-AC, p < 0.001). Results were similar in the subgroup of patients with perfusion abnormalities on myocardial SPECT/CT images. Overall diagnostic performances were similar for the CTAC and non-AC methods for evaluating normal and decreased LVEF by myocardial SPECT/CT. Conclusion LVEF measured by the CTAC method of Tl-201-gated myocardial SPECT/CT was comparable with the conventional non-AC method in patients with angina pectoris and in the subgroup of patients with perfusion abnormality. Tl-201-gated myocardial hybrid SPECT/CT can be a reliable tool in the assessment of LVEF in clinic.

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“…And myocardial perfusion reserve even had stronger correlation with LVEF than infarct size. 24 Even in a previous clinical trial, there was a negative linear relation between infarct size and LVEF in patients with moderate to large infarcts. 25 Taken together, it is necessary to estimate the ventricular function in addition to infarct size when evaluating myocardial ischemia-reperfusion injury.…”

Section: Myocardial Infarction Sizementioning

confidence: 90%

Age-Related Difference in the Effect of Acute Hyperglycemia on Myocardial Ischemia-Reperfusion Injury

Ham

Nam

Kwak

et al. 2019

The Journals of Gerontology: Series A

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I would like to apprecieate to my thesis supervisor, Professor Yon Hee Shim, who has encouraged me throughout the whole process. This dissertation would not have been possible without her guidance and persistent help. And I would like to thank my committee members, Professor Young-Lan Kwak, Gijong Yi, Young Won Yoon, and Hyun-Soo Kim, whose expert, sincere and valuable advice and guidance truly enriched this doctoral thesis. I also wish to thank Ji Hae Jun and Eun Jung Shin, who have lent their helping hand in this venture. I take this opportunity to record my sincere thanks to all of my colleagues at the Department of Anesthesia and Pain Medicine for their help and encouragement.

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Evaluation of the influence of age and gender on the relationships between infarct size, infarct severity, and left ventricular ejection fraction in patients successfully treated with primary percutaneous coronary intervention

Cited by 5 publications

References 32 publications

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort

Assessment of Left Ventricular Ejection Fraction by Thallium-201 Myocardial SPECT-CT in Patients with Angina Pectoris: Comparison with 2D Echocardiography

Age-Related Difference in the Effect of Acute Hyperglycemia on Myocardial Ischemia-Reperfusion Injury

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