Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis

Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial

“…Our findings showed that both types of treatment showed statistically significant pocket depth reduction at T1 for both levels with no statistically significant different between the study 46 groups (A. Rola, K. Yousef, A. Wesam, unpublished data). These results are in agreement with the conclusions of previous studies conducted on patients with chronic and aggressive periodontitis .…”

Salivary Colony Stimulating Factor‐1 and Interleukin‐34 in Periodontal Disease

“…In patients with periodontitis, however, CSF‐1 and MMP‐8 stayed high after treatment despite improvement in clinical periodontal parameters. Published works by others on salivary MMP‐8 after treatment of periodontitis in patients differ depending on the time point for follow‐up 8 , 33 , 34 . MMP‐8 levels in gingival crevicular fluid (GCF) during wound healing after surgery were found increased at 2 and 4 weeks compared with baseline and decreased between 2 and 12 weeks 35 .…”

Periodontal Treatment Reduces Matrix Metalloproteinase Levels in Localized Aggressive Periodontitis

“…However, the authors used either SRP or adjunctive azithromycin therapy, and the population in the study consisted of generalized AgP patients. Another study aimed to compare the clinical status and MMP levels after SRP alone or with ozonotherapy in patients with AgP and CP, up to 2 months after treatment 22 . Interestingly, the authors reported that SRP with additional ozonotherapy provided an increase in MMP levels in patients with CP and a reduction in MMP levels in patients with AgP.…”