Evaluation of the Influence of a History of Childhood Nocturnal Enuresis on Nighttime Urinary Frequency and the Causes of Nocturia in Adults

Miyazato, Minoru; Gakiya, Munehisa; Ashikari, Asuka; Kamijo, Tadanobu Chuyo; Kagawa, Haruo; Matsuo, Tomohiro; Miyata, Yasuyoshi; Oshiro, Yoshinori; Arai, Koji Y.; Machida, Noriko; Shinzato, Hiroshi; Chinen, Yoshiaki; Iwata, Hiroyoshi; Ueda, Shinichiro; Saito, Seiichi

doi:10.1016/j.urology.2022.01.007

Cited by 1 publication

(2 citation statements)

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“…To our knowledge, in this study, we reported the first case of VPA-induced enuresis in an adult patient with epilepsy. The common causes of nocturnal enuresis in adults include urinary disease, the use of certain drugs, sleep disorders, mental status, and metabolic disorders ( 10 , 18 ). Unfortunately, we did not evaluate the patient for urinary tract infection, genitourinary anatomical abnormalities, or sleep quality in this study.…”

Section: Discussionmentioning

confidence: 99%

“…How VPA induces nocturnal enuresis remains unclear, although several mechanisms have been emphasized. ADH is synthesized and secreted in the hypothalamic paraventricular nucleus and acts as a potent vasoconstrictor and anti-diuretic hormone ( 18 , 20 ). The insufficient secretion of ADH plays a role in the pathophysiology of child enuresis, and ADH replacement therapy was effective in treating some children with enuresis ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

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Sodium valproate-induced nocturnal enuresis in epilepsy: Three case reports and a review of the literature

Zhang¹,

Lü

2023

Front. Neurol.

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BackgroundEnuresis is an uncommon adverse effect of sodium valproate therapy that is unknown to most clinicians. This study provides an overview of the literature on enuresis associated with sodium valproate therapy, discussing the clinical manifestations and possible mechanisms of this side effect.MethodsWe reported three cases of enuresis induced by sodium valproate and reviewed the published enuresis cases associated with sodium valproate therapy retrieved from databases.Case presentation and resultsThree new patients with epilepsy who presented with enuresis following sodium valproate therapy were reported, and 55 published cases of nocturnal enuresis associated with sodium valproate were evaluated. The average age of these patients varied from 4 to 20 years. A total of 48 cases had generalized seizures, seven had focal seizures, and three had unknown seizures. In all the patients, the plasma concentration of sodium valproate was 80.76 ± 14.80 μg/mL, within the therapeutic range when enuresis occurred. With discontinuation or reduction of the drug, all the patients recovered completely.ConclusionSodium valproate-induced enuresis is a rare and reversible side effect, occurring at a younger age, characterized by the generalized onset of seizures, and a rather high dose. The possible mechanisms include insufficient secretion of anti-diuretic hormones, sleep disorder, and hyperactivity of the parasympathetic system. Clinicians should be aware of this uncommon side effect to avoid an incorrect adjustment of the treatment direction.

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Section: Discussionmentioning

confidence: 99%