Evaluation of the influence of polymorphic variants CYP1A1*2B, CYP1B1*2, CYP3A4*1B, GSTM1*0, and GSTT1*0 in prostate cancer

Rodrigues, Iara S.; Kuasne, Hellen; Guembarovski, Roberta Losi; Fuganti, Paulo Emílio; Gregório, Émerson Pereira; Kishima, Marina Okuyama; Ito, Kazuhiro; Rodrigues, Marco Aurélio de Freitas; Cólus, Ilce Mara de Syllos

doi:10.1016/j.urolonc.2010.01.009

Cited by 26 publications

(10 citation statements)

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“…Finally, we identified 14 independent studies in 13 eligible reports [18]–[30], including 6380 cases and 5807 controls. There were 6 groups of Caucasians [18], [20], [22], [23], [30], 3 of Asians [25], [27], [29], 1 of Africans [21], and 4 of mixed population [19], [24], [26], [28]. 5 studies were population-based [18], [19], [25], [29], [30] and 9 studies were hospital-based [20]–[24], [26]–[28].…”

Section: Resultsmentioning

confidence: 99%

CYP1B1 Polymorphisms and Susceptibility to Prostate Cancer: A Meta-Analysis

Zhang

2013

PLoS ONE

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BackgroundStudies investigating the association between single-nucleotide polymorphisms (SNPs) of the cytochrome P450 1B1 (CYP1B1) and prostate cancer (PCa) risk report conflicting results. To derive a more precise estimation of the relationship between CYP1B1 polymorphisms and PCa risk, a meta-analysis was performed.Methodology/Principal FindingsA comprehensive literature search was conducted to identify all eligible studies of CYP1B1 polymorphisms and PCa risk. A total of 14 independent studies, including 6380 cases and 5807 controls, were identified. We investigated by meta-analysis the effects of 5 polymorphisms in CYP1B1 L432V (12 studies, 5999 cases, 5438 controls), R48G (6 studies, 1647 cases, 1846 controls), N453S (4 studies, 1407 cases, 1499 controls), −13C/T (4 studies, 1116 cases, 1114 controls), and A119S (4 studies, 1057 cases, 1018 controls). There was no evidence that L432V had significant association with PCa in overall population. After subgroup analyses by ethnicity, we found that L432V was significantly associated with PCa risk in Asians (additive: OR = 2.38, 95%CI = 1.31-4.33, P = 0.004; recessive: OR = 2.11, 95%CI = 1.17–3.79, P = 0.01; dominant: OR = 1.52, 95%CI = 1.14–2.01, P = 0.004; allelic: OR = 1.52, 95%CI = 1.20–1.92, P = 0.0006). When stratified by source of controls, significantly elevated PCa risk was found in all genetic models in population based studies (additive: OR = 1.34, 95%CI = 1.14–1.57, P = 0.0003; recessive: OR = 1.25, 95%CI = 1.09–1.43, P = 0.002; dominant: OR = 1.25, 95%CI = 1.11–1.41, P = 0.0002; allelic: OR = 1.18, 95%CI = 1.09–1.28, P<0.0001). For N453S, there was a significant association between N453S polymorphism and PCa risk in both overall population (dominant: OR = 1.18, 95%CI = 1.00–1.38, P = 0.04) and mixed population (domiant: OR = 1.31, 95%CI = 1.06–1.63, P = 0.01; allelic: OR = 1.27, 95%CI = 1.05–1.54, P = 0.01). For A119S, our analysis suggested that A119S was associated with PCa risk under recessive model in overall population (OR = 1.37, 95%CI = 1.04–1.80, P = 0.03).ConclusionsThe results suggest that L432V, N453S, and A119S polymorphisms of CYP1B1 might be associated with the susceptibility of PCa. Further larger and well-designed multicenter studies are warranted to validate these findings.

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Section: Resultsmentioning

confidence: 99%

CYP1B1 Polymorphisms and Susceptibility to Prostate Cancer: A Meta-Analysis

Zhang

2013

PLoS ONE

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“…[98] Although genetic factors are considered to be a crucial part of the pathogenic process of BCa, especially the polymorphisms in metabolic pathways. [99] As one of the most important parts of phase II super family of metabolism enzymes, GSTs are composed of 7 classes (α, μ, ω, π, σ, θ, ξ). [100] Among them, GSTA1, GSTM1, GSTP1, and GSTT1 are considered to be the most important.…”

Section: Discussionmentioning

confidence: 99%

The relationship between GSTA1, GSTM1, GSTP1, and GSTT1 genetic polymorphisms and bladder cancer susceptibility

Yan

Liang³

et al. 2016

Medicine

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Background:Previous studies have investigated the relationship between GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and bladder cancer (BCa) susceptibility, respectively, but the results remain inconsistent. So, we conducted this meta-analysis including 79 case–control studies to explore such relationships.Methods:We searched PubMed, EMBASE, Cochrane library, Web of Science, and CNKI for relevant available studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were implemented to evaluate the intensity of associations. Publication bias was estimated using Begg funnel plots and Egger regression test. To assess the stability of the results, we used sensitivity analysis with the method of calculating the results again by omitting 1 single study each time. Between-study heterogeneity was tested using the I2 statistic.Results:No significant association between GSTA1 polymorphism and BCa susceptibility (OR = 1.05, 95% CI 0.83–1.33) was noted. Besides, meaningful association between individuals who carried the GSTM1 null genotype and increased BCa risk was detected (OR = 1.39, 95%CI 1.28–1.51). When stratified by ethnicity, significant difference was found in both Caucasian (OR = 1.39, 95% CI 1.23–1.58) and Asian populations (OR = 1.45, 95% CI 1.31–1.61). Moreover, in the subgroup analysis by source of controls (SOC), the results were significant in both hospital-based control groups (OR = 1.49, 95% CI 1.35–1.64) and population-based control groups (OR = 1.21, 95% CI = 1.07–1.37). Additionally, the analysis revealed no significant association between GSTP1 polymorphism and BCa risk (OR = 1.07, 95% CI 0.96–1.20). What is more, significant associations between GSTT1 polymorphism and BCa susceptibility were discovered (OR = 1.11, 95% CI 1.00–1.22). In the subgroup analysis by ethnicity, significant associations between GSTT1 null genotype and BCa risk were observed only in Caucasians (OR = 1.25, 95% CI 1.09–1.44). Furthermore, when stratified by SOC, no obvious relationship was found between the GSTT1 null genotype polymorphism with hospital-based population (OR = 1.11, 95% CI 0.97–1.28) or population-based population (OR = 1.10, 95% CI 0.96–1.27).Conclusion:This study suggested that GSTM1 null genotype and GSTT1 null genotype might be related to higher BCa risk, respectively. However, no associations were observed between GSTA1 or GSTP1 polymorphisms and BCa susceptibility.

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“…With our search criterion, 87 individual records were found and 16 studies with a total of 11,648 subjects were finally included in this meta-analysis [13,14,15,16,17,27,28,29,30,31,32,33,34,35,36,37]. Table 1 shows the main characteristics of those 16 case-control studies.…”

Section: Resultsmentioning

confidence: 99%

“…The most common variant of GSTT1 gene is homozygous deletion (null genotype) which has been suggested to be associated with the loss of enzyme activity, and increased vulnerability to cytogenetic damage and oxidative DNA damage [11]. Many studies have investigated the association between GSTT1 null genotype and the risk of PCa, but the impact of GSTT1 null genotype on PCa in Caucasians is still unclear owing to the obvious inconsistency among such studies [13,14,15,16,17]. The present study aimed to quantify the strength of association between GSTT1 null genotype and the risk of PCa in Caucasians.…”

Section: Introductionmentioning

confidence: 99%

<b><i>GSTT1</i></b> Null Genotype Is Associated with an Increased Risk of Prostate Cancer in Caucasians: A Meta-Analysis

Zhu¹,

Chen²,

Xu³

et al. 2013

Urol Int

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Background: Many studies have investigated the association between glutathione S-transferase T1 (GSTT1) null genotype and the risk of prostate cancer (PCa), but the impact of GSTT1 null genotype on PCa risk in Caucasians is still unclear owing to the inconsistency of such studies. The present study aimed to quantify the strength of association between GSTT1 null genotype and the risk of PCa in Caucasians. Methods: We searched the PubMed, Embase and Web of Science databases for studies assessing the association between GSTT1 null genotype and the risk of PCa in Caucasians. We estimated the summary odds ratio (OR) with the corresponding 95% confidence interval (95% CI) to assess the association. Results: 16 case-control studies with 11,648 subjects were included in this meta-analysis. Meta-analysis of a total of 16 studies showed GSTT1 null genotype was significantly associated with an increased risk of PCa in Caucasians (random-effects OR 1.30, 95% CI 1.10-1.53, p = 0.002). After adjustment for heterogeneity, GSTT1 null genotype was still associated with an increased risk of PCa in Caucasians (fixed-effects OR 1.33, 95% CI 1.17-1.52, p < 0.001). The cumulative meta-analyses of all 16 studies showed a trend of more obvious association as information accumulated by year. Conclusions: Meta-analysis of available data suggests the GSTT1 null genotype is significantly associated with an increased risk of PCa in Caucasians.

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Evaluation of the influence of polymorphic variants CYP1A12B, CYP1B12, CYP3A41B, GSTM10, and GSTT1*0 in prostate cancer

Cited by 26 publications

References 44 publications

CYP1B1 Polymorphisms and Susceptibility to Prostate Cancer: A Meta-Analysis

CYP1B1 Polymorphisms and Susceptibility to Prostate Cancer: A Meta-Analysis

The relationship between GSTA1, GSTM1, GSTP1, and GSTT1 genetic polymorphisms and bladder cancer susceptibility

<b><i>GSTT1</i></b> Null Genotype Is Associated with an Increased Risk of Prostate Cancer in Caucasians: A Meta-Analysis

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