Evaluation of the influence of inlet boundary conditions on computational fluid dynamics for intracranial aneurysms: A virtual experiment

Pereira, Vítor Mendes; Brina, Olivier; Gonzales, A.; Narata, Ana Paula; Bijlenga, Philippe; Schaller, Karl; Lövblad, Karl-Olof; Ouared, Rafik

doi:10.1016/j.jbiomech.2013.03.024

Cited by 41 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To do this comparison, the pretreatment characteristic curve can be obtained either with clinical measurements, using optical flow techniques (Bonnefous et al, 2012;Pereira et al, 2013aPereira et al, , 2013b or through CFD. Then, one (or more) post-treatment hemodynamic condition(s), obtained at any flow rate can be compared with the pre-treatment curve (Fig.…”

Section: Usability Of the Curvesmentioning

confidence: 99%

See 1 more Smart Citation

Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics

Morales

Bonnefous

2015

Journal of Biomechanics

View full text Add to dashboard Cite

Section: Usability Of the Curvesmentioning

confidence: 99%

“…A parabolic profile was imposed at the inlet, which can produce different flow patterns compared to a Womersley-based profile. To reduce potential errors, the vascular models were not truncated and the largest available arterial segments upstream the aneurysms were kept from the 3D rotational angiographic images (Pereira et al, 2013b).…”

Section: Limitationsmentioning

confidence: 99%

Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics

Morales

Bonnefous

2015

Journal of Biomechanics

View full text Add to dashboard Cite

“…These findings indicated that realistic simulation of the hemodynamics in this kind of cerebral aneurysm required realistic, i.e., measured, inflow boundary conditions (Karmonik et al 2009). Another approach for validating CFD simulations is the creating of virtual angiographic images or comparing the CFD results with dynamic 2D fluoroscopic images (high-frame-rate DSA images) (Pereira et al 2013;Endres et al 2012;Sun et al 2012) or particle imaging velocimetry (Ford et al 2008). …”

Section: Validation Approachesmentioning

confidence: 99%

Computational Fluid Dynamics and Cerebral Aneurysms

Karmonik

Britz

2014

PanVascular Medicine

View full text Add to dashboard Cite

Advances in computational techniques mitigated by faster computer hardware and improvements in software algorithms have increased interest in exploring their potential value for application in clinical research. Information derived from medical image data can be utilized to create computational models for simulating hemodynamics in cerebral aneurysms. In this chapter, we review the principles of computational fluid dynamics (CFD) aimed at this application and discuss results from selected studies which focused on developing CFD techniques for applications in clinical research. Validation studies comparing measurements with simulation results have demonstrated that this approach is viable and thereby encourage further development and refinement. They have also shown that multidisciplinary collaborative teams involving clinicians and clinical and basic scientists are needed to lead these exciting translational research efforts to fruition. Glossary of Terms AneurysmA focal balloon-like extension or bulge in a blood vessel. Cerebral aneurysms affect arteries of the brain, while aortic aneurysms are located in the aorta. Computational fluid dynamicsA subspecialty of the large field of fluid mechanics in which numerical algorithms are developed and used with high-performance computers to solve problems related to fluid flow. Computed tomography angiographyA medical imaging technology where the computational analysis of X-rays is combined with the administration of a contrast agent to create three-dimensional visualization of blood vessels and the heart. Digital subtraction angiography A medical imaging technique based on fluoroscopy, where images acquired before and after the administration of a contrast agent are subtracted to obtain very accurate visualizations of blood vessels with high spatial resolution. Endothelium A thin layer of cells lining the inner surface of blood vessels. Endothelial cells have been shown to have receptors for sensing the wall shear stress created by the flowing blood. Endovascular treatmentA surgical technique to treat selected vascular pathologies in the brain and other parts of the body through a catheter and attached medical devices which are navigated to the treatment site within the blood vessels.*Email: ckarmonik@tmhs.org *Email: ckarmonik@houstonmethodist.org PanVascular Medicine DOI 10.1007/978-3-642-37393-0_33-1 # Springer-Verlag Berlin Heidelberg 2014Page 1 of 13 HemodynamicsThe field which aims at developing a better understanding of how blood flows in blood vessels by establishing the corresponding physical laws and the governing equations of motion. Magnetic resonance imagingA medical imaging technology which uses strong magnetic fields and radio-frequency pulses to probe and visualize anatomy and physiology both in health and disease. Mesh generationThe digital separation of an often irregularly shaped volume into small regular volume elements, for instance, tetrahedra, pyramids, or hexahedra. This is a prerequisite for applying computational simulations which rely ...

show abstract

“…The results indicated that it was necessary to set the upstream boundaries at a distance 20 times longer than the inlet diameter away from the cerebral aneurysm. Meanwhile, Pereira et al carried out CFD for three blood vessel models with different inlet locations with and without a bend to investigate the appropriate upstream boundary conditions (Pereira et al, 2013). They showed that quantitative differences in the hemodynamic parameters inside the aneurysm occurred if the bend of the blood vessel between the inlet and the cerebral aneurysm and the upstream velocity distribution were changed.…”

Section: Introductionmentioning

confidence: 99%

Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm

Suzuki

Funamoto

Sugiyama

et al. 2017

JBSE

View full text Add to dashboard Cite

Mechanisms of development, growth, and rupture of a cerebral aneurysm have been studied by computational fluid dynamics (CFD), calculating hemodynamic parameters, such as wall shear stress, oscillatory shear index (OSI), and relative residence time (RRT). It is well known that the upstream velocity profile and upstream vessel shape influence the computational results. However, few studies have dealt with cases involving a bifurcation upstream of a cerebral aneurysm. Furthermore, the fluid-dynamic effects of multiple structural elements of upstream vessel shape, such as a bifurcation and a bend, on the results of CFD remain unknown. The purpose of this study was to elucidate the fluid-dynamic effects of multiple structural elements of upstream vessel shape such as bifurcation and bend on blood flow and hemodynamic parameters inside an aneurysm. Computations were performed for blood flow in a cerebral aneurysm with upstream sequential elements of a bifurcation, a bend, and a straight section, using four models with different upstream boundaries, i.e., before the bifurcation, after the bifurcation before the bend, after the bend, and after the straight section just before the cerebral aneurysm. The results were compared to elucidate the effect of each upstream structural element on the blood flow and hemodynamic parameters in the cerebral aneurysm. Differences in OSI and RRT resulting from changes in the velocity distribution were observed locally in the aneurysm between the models. It was also found that the effect of the bifurcation on the velocity distribution was greater than that of the bend.

show abstract

Evaluation of the influence of inlet boundary conditions on computational fluid dynamics for intracranial aneurysms: A virtual experiment

Cited by 41 publications

References 21 publications

Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics

Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics

Computational Fluid Dynamics and Cerebral Aneurysms

Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm

Contact Info

Product

Resources

About