2022
DOI: 10.3390/ijerph191710516
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Evaluation of the Influence of Biological Factors during the Course of Treatment in Patients with Ovarian Cancer

Abstract: The aim of this study was to evaluate the influence of β-endorphins and serotonin on the course of treatment, disease-free time, and overall survival of patients with ovarian cancer. This study may contribute to the identification of modifiable factors that may influence the treatment of ovarian cancer. The research was carried out in a group of 162 patients of which 139 respondents were included in the research; ovarian cancer was diagnosed in 78 of these patients. The study consisted of three stages. In the … Show more

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Cited by 2 publications
(4 citation statements)
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“…This topic must also be developed, and the published promising data confirmed: an increased risk for developing breast cancer has been associated with a low plasma level of pro-enkephalin [146]; beta-END immunoreactivity was lower in benign melanocytic naevi than in metastatic and advanced melanomas [232], and a positive correlation between plasma beta-END levels and survival time/disease-free time has been suggested in patients with ovarian cancer: lower beta-END concentrations were observed in patients with recurrence than in those without recurrence [248]. MET improved survival/clinical symptoms in patients with advanced pancreatic cancer [252]; high MET plasma levels in patients with pancreatic cancer have been reported [253]; zeta-opioid receptors are more expressed in prostate cancer tissues than in normal ones, and this expression was high in aggressive and undifferentiated prostate cancer tissues [272].…”
Section: The Opioid System As a Cancer-predictive Factormentioning
confidence: 81%
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“…This topic must also be developed, and the published promising data confirmed: an increased risk for developing breast cancer has been associated with a low plasma level of pro-enkephalin [146]; beta-END immunoreactivity was lower in benign melanocytic naevi than in metastatic and advanced melanomas [232], and a positive correlation between plasma beta-END levels and survival time/disease-free time has been suggested in patients with ovarian cancer: lower beta-END concentrations were observed in patients with recurrence than in those without recurrence [248]. MET improved survival/clinical symptoms in patients with advanced pancreatic cancer [252]; high MET plasma levels in patients with pancreatic cancer have been reported [253]; zeta-opioid receptors are more expressed in prostate cancer tissues than in normal ones, and this expression was high in aggressive and undifferentiated prostate cancer tissues [272].…”
Section: The Opioid System As a Cancer-predictive Factormentioning
confidence: 81%
“…A positive correlation has been reported between survival time/disease-free time and plasma beta-END level in patients with ovarian cancer [248]. Lower beta-END concentrations were observed in patients with recurrence than those without recurrence [248]. Moreover, beta-END and MET blocked the proliferation of human ovarian KF cancer cells; this effect was counteracted with naloxone, and it seems that both peptides blocked protein/RNA synthesis but not DNA synthesis [249].…”
Section: Endorphinmentioning
confidence: 90%
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“…Patients with ovarian cancer are at constant risk of experiencing negative emotional states, anxiety and depression. Chronic stress may contribute to biological responses leading to the process of carcinogenesis [5]. In patients diagnosed with cancer, anxiety is related to cancer progression indicated as one of the main factors causing anxiety symptoms [6].…”
Section: Introductionmentioning
confidence: 99%