Evaluation of the Infertile Male

Kim, Edward D.; Lipshultz, Larry I.

doi:10.1007/978-1-4613-1105-8_9

Cited by 2 publications

(2 citation statements)

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“…Patients who were treated with greater than 3 courses or with radiotherapy had spermatogenesis return after 24 months from the end of treatment [45]. Because of the risk of underlying DNA damage to sperm from chemotherapy and radiation, it is the recommendation by the American Society of Reproductive Medicine (ASRM) and the American Urological Association (AUA) that conception is not attempted with freshly ejaculated or extracted sperm within 2 years of receiving chemotherapy or radiation [46]. Studies of children with a paternal history of cancer were more likely to have major congenital abnormalities if conceived within 2 years of paternal receipt of chemotherapy/radiation [47].…”

Section: Chemotherapymentioning

confidence: 99%

Sexual function and fertility preservation in testicular cancer survivors

2023

Journal of Men's Health

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Testicular cancer is a common cancer among reproductive age men, with the necessary treatment options having varying impacts on fertility and sexual function. Treatment begins with orchiectomy and is often followed by a combination of chemotherapy, radiation, and/or retroperitoneal lymph node dissection, which have different effects on spermatogenesis, gonadotropin levels, and ejaculation. Alkylating agents such as cisplatin are commonly used for testicular cancer and are amongst the most spermatotoxic chemotherapeutic agents. Radiation poses gonadotoxic effects despite gonadal shielding due to a scatter effect. Suprahilar and bilateral retroperitoneal lymph node dissections can cause ejaculatory dysfunction. Options to preserve fertility vary by pubertal status. While the standard recommendation for post pubertal patients is cryopreservation, prepubertal patients rely on experimental protocols for cryopreservation of germ cells with stem cell capabilities, with the hope that these cells will one day be stimulated to produce sperm. These topics are reviewed to give insight into current literature around fertility in testicular cancer survivorship and determine best possible practices in fertility preservation among patients.

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Section: Chemotherapymentioning

confidence: 99%

Sexual function and fertility preservation in testicular cancer survivors

2023

Journal of Men's Health

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“…Given that male factor issues are causative in approximately 20% of infertile couples (Hull et al, 1985; Mosher and Pratt, 1990) and contributory in up to another 30%‐40% (World Health Organization [WHO], 1987; Practice Committee of the ASRM and AUA, 2001), a thorough assessment of the male partner is essential but nevertheless often overlooked. Numerous reviews are available that explore male factor evaluation (de Kretser, 1997; Kim and Lipschultz, 1999; Spitz et al, 2000; Burrows et al, 2002). A brief overview follows.…”

Section: Male Evaluationmentioning

confidence: 99%