Evaluation of the Incidence of Human Papillomavirus–Associated Squamous Cell Carcinoma of the Sinonasal Tract Among US Adults

London, Nyall R.; Windon, Melina J.; Amanian, Ameen; Zamuner, Fernando T.; Bishop, Justin A.; Fakhry, Carole; Rooper, Lisa M.

doi:10.1001/jamanetworkopen.2022.55971

Cited by 5 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same issue of ctHPVDNA confounding occurs in metachronous primaries, where a rise in ctHPVDNA might signify recurrence of the initial tumor or a second primary cancer. Interestingly, both of these cases represent multiple primaries in which one occurred in the oropharynx and one in the sinonasal cavity, a phenomenon which appears to be increasing in incidence 10 . There is an additional possibility that a metachronous primary could reside outside of the head and neck, such as in the anogenital tract, where HPV is also the major carcinogenic agent.…”

Section: Discussionmentioning

confidence: 99%

Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring

et al. 2023

View full text Add to dashboard Cite

Background: Human papillomavirus-associated head and neck squamous cell carcinoma (HPV + HNSCC) occurs in the oropharynx (HPV + OPSCC), sinonasal cavity (HPV + SNSCC), and nasopharynx (HPV + NPC). Circulating tumor HPV DNA (ctHPVDNA) is an accurate tool for diagnosis, treatment monitoring, and recurrence detection. An emerging challenge with ctHPVDNA is that $7.4% of HPV + HNSCC patients develop synchronous or metachronous HPV+ primaries, which could confound ctHPVDNA monitoring.Methods: We describe a 65-year-old patient with T2N1M0 HPV16 + OPSCC and a 55-year-old patient with T2N2M0 HPV16 + OPSCC. Both patients were enrolled in our prospective observational ctHPVDNA study with longitudinal blood collections throughout treatment. Both patients developed multiple HPV+ primaries.Results: Detailed discussion of the patients' treatment courses, the subsequent diagnoses of their second HPV+ primaries, and their ctHPVDNA monitoring is presented.Conclusions: As ctHPVDNA use becomes more prevalent, it is important to recognize that an increase in ctHPVDNA can come not only from the primary tumor or metastatic clones, but also from synchronous or metachronous second primaries.

show abstract

Section: Discussionmentioning

confidence: 99%

Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring

et al. 2023

View full text Add to dashboard Cite

show abstract

Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer

Eberly,

Sciscent,

Lorenz

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Head and neck cancers (HNC) are a biologically diverse set of cancers that are responsible for over 660,000 new diagnoses each year. Current therapies for HNC require a comprehensive, multimodal approach encompassing resection, radiation therapy, and systemic therapy. With an increased understanding of the mechanisms behind HNC, there has been growing interest in more accurate prognostic indicators of disease, effective post-treatment surveillance, and individualized treatments. This chapter will highlight the commonly used and studied biomarkers in head and neck squamous cell carcinoma.

show abstract

p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes

Hirakawa,

Ikegami,

Touyama

et al. 2023

JCM

View full text Add to dashboard Cite

p16 overexpression is often used as a surrogate marker for human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma but remains an uncertain diagnostic tool for HPV-related sinonasal squamous cell carcinoma (SNSCC). Our study involved 79 consecutive SNSCC patients who were treated at a tertiary referral university hospital during 2006–2021. We retrospectively examined their clinical characteristics and conducted p16 immunohistochemistry and HPV detection. We found that 12.7% of the patients exhibited p16 overexpression, which was significantly more common in the nasal cavity and increased from 2015 onward. The HPV was a high-risk type and viral loads ranged from 4.2 to 1.6 × 106 copies/ng DNA with genome integration. Five-year overall survival (OS) and five-year relapse-free survival (RFS) rates were 74.6% and 69.9%, respectively. Our multivariate analysis showed that T category (T1–4a) and hemoglobin levels (≥13.7) were significant favorable prognostic factors for OS, while T category, performance status, and p16 overexpression were significantly associated with RFS. In patients with p16 overexpression, OS was 100% and RFS was 90%. Our findings suggest that p16 overexpression is a reliable surrogate marker for transcriptionally active HPV infection and predicts a favorable prognosis.

show abstract

Evaluation of the Incidence of Human Papillomavirus–Associated Squamous Cell Carcinoma of the Sinonasal Tract Among US Adults

Abstract: This case series assesses the incidence of human papillomavirus (HPV)-associated sinonasal squamous cell carcinoma (SNSCC) and the prevalence of HPV-positive SNSCC among US adults.

Cited by 5 publications

References 5 publications

Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring

Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring

Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer

p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes

Contact Info

Product

Resources

About