Evaluation of the in vitro antimicrobial activity of selected Saudi scorpion venoms tested against multidrug-resistant micro-organisms

Alasmari, Abdulrahman; Alamri, Meshref Ali; Almasoudi, Aqeel Salman; Abbasmanthiri, Rajamohamed; Mahfoud, Maysa

doi:10.1016/j.jgar.2017.03.008

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…In the case of Leiurus quinquestriatus , a broad antimicrobial activity of the tested compounds was observed. However, there is not enough information regarding the interaction of these compounds with specific molecules of some microorganisms [ 246 ]. A high antimicrobial activity was observed for AMPs obtained from Vespa affinis (mastoparan) [ 247 ], Capra hircus (minibactenecins) [ 248 ], Lucilla serricata (sarcotoxin) [ 249 ] and from Rana catesbeiana (ranalexin and danalexin) [ 250 ].…”

Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

et al. 2020

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Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe nosocomial infections is Acinetobacter baumannii, a Gram-negative bacterium from the Moraxellaceae family, due to its various resistance mechanisms, such as the β-lactamases production, efflux pumps, decreased membrane permeability and altered target site of the antibiotic. The enormous adaptive capacity of A. baumannii and the acquisition and transfer of antibiotic resistance determinants contribute to the ineffectiveness of most current therapeutic strategies, including last-line or combined antibiotic therapy. In this review, we will present an update of the antibiotic resistance profiles and underlying mechanisms in A. baumannii and the current progress in developing innovative strategies for combating multidrug-resistant A. baumannii (MDRAB) infections.

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Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

et al. 2020

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“…Therefore, Al-Asmari et al evaluate the in vitro antimicrobial activities of the toxins extracted from three medically necessary Saudi Scorpions. Among these, only Leiurus quinquestriatus showed significant broad-spectrum antimicrobial activity in a dosedependent manner from 5 to 20 mg/mL, inhibiting 50.6% of growth and survival of MDR A. baumannii [80]. High antimicrobial activity was also observed for AMPs ranalexin and danalexin obtained from Rana catesbeiana [81], LS-sarcotoxin, and LS-stomoxyn (Lucilla serricata) [82], and minibactenecins (Capra hircus) [83].…”

Section: Snake Cathelicidinsmentioning

confidence: 99%

Peptides with Therapeutic Potential against Acinetobacter baumanii Infections

Rangel¹,

De-Simone²

2022

Insights on Antimicrobial Peptides

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Antibiotic poly-resistance (multi drug-, extreme-, and pan-drug resistance) is a major global threat to public health. Unfortunately, in 2017, the World Health Organization (WHO) introduced the carbapenemresistant isolates in the priority pathogens list for which new effective antibiotics or new ways of treating the infections caused by them are urgently needed. Acinetobacter baumannii is one of the most critical ESKAPE pathogens for which the treatment of resistant isolates have caused severe problems; its clinically significant features include resistance to UV light, drying, disinfectants, and antibiotics. Among the various suggested options, one of the antimicrobial agents with high potential to produce new anti-Acinetobacter drugs is the antimicrobial peptides (AMPs). AMPs are naturally produced by living organisms and protect the host against pathogens as a part of innate immunity. The main mechanisms action of AMPs are the ability to cause cell membrane and cell wall damage, the inhibition of protein synthesis, nucleic acids, and the induction of apoptosis and necrosis. AMPs would be likely among the main anti-A. baumannii drugs in the post-antibiotic era. Also, the application of computer science to increase anti-A. baumannii activity and reduce toxicity is also being developed.

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“…Buffalo milk lactoperoxidase against S. enterica and L. monocytogenes [ 359 ]; colistin against MDR Acinetobacter [ 33 ]; lactic acid bacteria from raw camel milk [ 360 ]; peptides, including hybrid peptides and ultrashort peptides [ 343 , 344 , 352 ]; ultrashort antimicrobial peptide nanoparticles [ 356 ]; Isatin-benzoazine molecular hybrids [ 361 ]; chemical derivatives [ 362 , 363 , 364 , 365 ]; extracts of Matricaria aurea [ 366 ]; extracts of Nepeta deflersiana [ 223 ]; Saudi scorpion venoms [ 367 ]; artemisinin extract [ 368 ]; biocidal polymers [ 369 ]; microtubule depolymerizing agents [ 370 ]; ozonated water [ 250 ]; and marine Streptomyces sp [ 371 ] against MDRO were all tested in the study region. Nanomaterials, nanoparticles and nanoformulations [ 351 , 356 , 358 , 372 , 373 ], as well as silver nanomaterials derived from marine Streptomyces [ 374 ] were also tested against the growth of multidrug-resistant micro-organisms.…”

Section: Mining Natural and Novel Antimicrobials Against Mdrmentioning

confidence: 99%

Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

Borgio

Rasdan

Sonbol

et al. 2021

Biology

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We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% (n = 453) of multidrug-resistant, microbe-associated mortality (n = 871) in the Arabian Peninsula was due to MDR Acinetobacter baumannii, Mycobacterium tuberculosis and Staphylococcus aureus infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR A. baumannii (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality (n = 210). A total of 13,087 Mycobacterium tuberculosis isolates were reported in the region. Candida auris (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.

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Evaluation of the in vitro antimicrobial activity of selected Saudi scorpion venoms tested against multidrug-resistant micro-organisms

Cited by 11 publications

References 18 publications

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

Peptides with Therapeutic Potential against Acinetobacter baumanii Infections

Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

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