Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest

Sader, Hélio S.; Mimica, I; Rossi, Flávia; Zoccoli, Cássia; Montelli, Augusto Cézar; Sampaio, Jorge Luiz Mello; Segura, A; Magalhães, Marcelo; Nowakonski, Angela von; Mendes, Caio

doi:10.1016/s0732-8893(97)00015-1

Cited by 22 publications

(8 citation statements)

References 13 publications

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“…have been informative. In Brazil, several recent multicenter studies similar to those cited have generated important data regarding the in vitro activity of newer β‐lactams and fluoroquinolones tested against local pathogens [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Sader

Jones

Winokur

et al. 1999

Clinical Microbiology and Infection

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OBJECTIVE: To evaluate the antimicrobial susceptibility patterns among 469 pathogens isolated as a significant cause of urinary tract infections in 10 Latin American medical centers. METHODS: Consecutively collected isolates were susceptibility tested by broth microdilution methods, and selected isolates were characterized by molecular typing methods. RESULTS: Escherichia coli and Klebsiella spp. isolates revealed high rates of resistance to broad-spectrum penicillins and to fluoroquinolones. Ceftazidime MICs of >/=2 mg/L, suggesting the production of extended-spectrum b-lactamases (ESBLs), were observed in 37.7% of K. pneumoniae and 8.3% of Escherichia coli isolates. Enterobacter spp. isolates were characterized by high resistance rates to ciprofloxacin (35%) and to ceftazidime (45%), but they generally remained susceptible to cefepime (95% susceptible). Pseudomonas aeruginosa and Acinetobacter spp. were highly resistant to ciprofloxacin and ceftazidime. Imipenem was active against 80% of P. aeruginosa and 93% of Acinetobacter spp. isolates. CONCLUSIONS: Our results demonstrate a high level of resistance to various classes of antimicrobial agents among isolates causing nosocomial urinary tract infections in Latin American hospitals. Clonal dissemination of ESBL-producing K. pneumoniae strains was infrequent.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Sader

Jones

Winokur

et al. 1999

Clinical Microbiology and Infection

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“…Apesar de as ESBLs serem inibidas por inibidores de β-lactamases (ácido clavulânico, sulbactam e tazobactam), somente 70,0% das amostras de Klebsiella spp. foram sensíveis a piperacilina/tazobactam, indicando, como já demonstrado em outros estudos (33,34) , que esse composto não apresenta boa atividade in vitro contra amostras produtoras de ESBL. Outros antibióticos que apresentaram boa atividade contra Klebsiella spp.…”

Section: Discussionunclassified

“…Dessa maneira, o uso desses β-lactâmicos no tratamento de infecções causadas por esses patógenos deve ser evitado, mesmo que a bactéria apresente sensibilidade in vitro (39,40) . Além de ser bastante estável a hidrólise por essas enzimas cromossômicas induzíveis, a cefepima apresenta maior potência contra cocos gram-positivos e excelente atividade contra P. aeruginosa, representando assim uma importante opção para o tratamento de infecções hospitalares, especialmente infecções do trato respiratório (7,10,16,17,34) . Em resumo, o Programa SENTRY de Vigilância de Resistência detectou alta prevalência de Acinetobacter spp.…”

Section: Discussionunclassified

Perfil de sensibilidade a antimicrobianos de bactérias isoladas do trato respiratório baixo de pacientes com pneumonia internados em hospitais brasileiros: resultados do Programa SENTRY, 1997 e 1998

et al. 2001

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“…The drug is considered a broad spectrum and shows an excellent activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter cloacae, Staphylococcus aureus and Estreptococos spp. [13], reaching a wide distribution into most body tissues and fluids and is excreted in human milk and urine [14,15], which at least 85% is excreted unchanged in human urine. This drug is mainly used for the treatment of lower respiratory infections, febrile neutropenic events, urinary tract infections skin soft tissue infections, complicated intra-abdominal infections, gynecological infections, and sepsis; it also can be used for children with bacterial meningitis [16,17].…”

Section: Introductionmentioning

confidence: 99%

Direct cefepime determination in human milk using solid mercury amalgam electrode manufactured with silver nanoparticles

Barbosa

Araújo

Trindade

et al. 2012

Journal of Electroanalytical Chemistry

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a b s t r a c tSolid silver mercury amalgam electrodes (AgSAEs) represent a suitable alternative to mercury electrodes due to their similar electrochemical properties and non-toxicity of the amalgam material. Based on this knowledge, we report the use of silver solid amalgam as working electrode to determine cefepime in human milk sample. Square-wave voltammogram registered for cefepime in Britton-Robinson buffer at pH 2.5, presented two well-defined reduction peaks, at À0.28 V (peak 1C) and À0.45 V (peak 2C). Under optimized condition, the calibration curves presented linear response from 3.0 Â 10 À7 to 2.1 Â 10 À6 mol L À1 with limits of detection and quantification of 8.51 Â 10 À9 and 2.84 Â 10 À8 mol L À1 , respectively. The applicability of the method was verified using spiked human milk samples and testing recovery percentages, which were ranged from 98.00% to 100.5%. The obtained results were also compared with those provided with the HPLC technique.

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Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest

Cited by 22 publications

References 13 publications

Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Perfil de sensibilidade a antimicrobianos de bactérias isoladas do trato respiratório baixo de pacientes com pneumonia internados em hospitais brasileiros: resultados do Programa SENTRY, 1997 e 1998

Direct cefepime determination in human milk using solid mercury amalgam electrode manufactured with silver nanoparticles

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