Evaluation of the in-line filters for the intravenous infusion of amphotericin B fluid

Hirakawa, Masaaki; Makino, Kazutaka; Nakashima, Kentaro; Kataoka, Yasufumi; Oishi, Ryozo

doi:10.1046/j.1365-2710.1999.00242.x

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…Chemical analysis could also determine any interactions between drugs and filter membrane, in relation to drug retention. A limited number of cases concord with this 29 , whereas most studies have revealed no variations in drug concentration when using in-line filters 30 – 33 . Room temperature should also be taken into account because of its impact on particle formation.…”

Section: Discussionmentioning

confidence: 81%

Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol

Perez

Décaudin

Chahla

et al. 2018

Sci Rep

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The large number of drugs administered simultaneously to neonates and children in hospital results in the formation of particles that are potentially infused. We have investigated the ability of IV in-line filters to eliminate particulate matter from multidrug infusion lines and so prevent contamination. The impact on particle occurrence of the internal volume of the IV line below the in-line filter was then evaluated. The multidrug therapy given to children was reproduced with and without in-line filtration. Three combinations with a filter were tested to vary the internal volume (V) between the filter and the catheter egress. The catheter was then connected to a dynamic particle count to evaluate the particulate matter potentially administered to children during infusion. The introduction of in-line filters led to a significant reduction in overall particulate matter, from 416,974 [208,479–880,229] to 7,551 [1,985–11,287] particles (p < 0.001). Larger particles of ≥10 and 25 µm were also significantly reduced. Adding an extension set to the egress of the in-line filter (V = 1.7 mL) caused a significant increase in particulate contamination for both. This study showed that in-line filtration is an effective tool in preventing particle administration to patients. Their position in the infusion in-line is therefore important because of its impact on internal volume and drug particle formation.

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Section: Discussionmentioning

confidence: 81%

Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol

Perez

Décaudin

Chahla

et al. 2018

Sci Rep

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show abstract

“…Therefore, the use of optimal filters for intravenous infusion of amphotericin B fluid appears to be sufficient to protect against the adverse reactions related to the aggregates. We previously reported that the filtration of amphotericin B solution and fluid through membrane filters and in‐line filters of polyethersulphone with pore sizes of 0·2 μm, respectively, significantly decreased particulate matters larger than 10 μm without altering the concentration of amphotericin B in the final intravenous fluid (14, 15). These filtration methods with membrane filters or in‐line filters are highly likely to be effective at minimizing the introduction of particulate matter, microbial contaminants and endotoxins into patients.…”

Section: Discussionmentioning

confidence: 99%

Particulate contamination of lyophilized amphotericin B preparation during reconstitution process

et al. 2001

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“…Huber and Riffkin reported that maximal activity of AmB‐d injection appeared when the pH is over the range of 6.0‐7.5. Moreover, along with pH decrease to less than 6.0, the colloidal solution may become turbid . Therefore, we supposed that the pH of AmB‐d final solution, rather than D5W, might be the essential factor for solubility.…”

Section: Discussionmentioning

confidence: 99%

Influence of 5% dextrose volume on amphotericin B deoxycholate preparation

Sun

Chen

Zhang

et al. 2016

Journal of Pharmacy and Pharmacology

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Evaluation of the in-line filters for the intravenous infusion of amphotericin B fluid

Abstract: The present results indicate that the 0.2 microm PES filter is optimal for intravenous infusion of amphotericin B fluid to minimize the introduction of particulate matter, microbial contaminants and endotoxin into patients.

Cited by 9 publications

References 14 publications

Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol

Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol

Particulate contamination of lyophilized amphotericin B preparation during reconstitution process

Influence of 5% dextrose volume on amphotericin B deoxycholate preparation

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