Evaluation of the impact of chronic kidney disease on the survival of octogenarian patients submitted to percutaneous coronary intervention

Abstract

ObjectiveTo evaluate the impact of chronic kidney disease on the survival of patients – 80 years of age undergoing percutaneous coronary intervention (PCI) in the long term.Methods273 subjects who underwent PCI between January 2010 and January 2016 were divided into four categories: (1) stable angina (SA) and creatinine clearance – 30 (n = 24); (2) patients with SA and CrCl <30 (n = 70); (3) patients with acute coronary syndrome (ACS) and CrCl – 30 (n = 51); (4) patients with ACS and ICC <30 (n = 128). Mortality curves were evaluated using the Kaplan-Meier method and differences between groups were compared by log-rank statistic. Multivariate analysis was performed using the Cox proportional hazards method. The 4 groups were compared and the survival between the groups was evaluated.ResultsOctogenarian patients with CrCl <30 with SA and ACS have lower long-term survival (p < 0.0001).ConclusionCKD has a worse long-term prognosis for patients undergoing PCI.

Invasive Strategy in Octogenarians with Non-ST-Segment Elevation Acute Myocardial Infarction

“…Chronic kidney disease is more prevalent in older patients because of the progressive loss of kidney function with age [ 22 ]. Cardiorrenal syndrome can also play a role in the severity of kidney injury, which is associated with worse outcomes [ 23 , 24 ]. The Impacto de la fragiLidad y Otros síndromes GEriátricos en el manejo y pronóstico Vital del ancianO con Síndrome Coronario Agudo sin elevación de segmento ST (LONGEVO-SCA) registry studied consecutive patients aged 80 years and assesed the impact of renal function in outcomes such as mortality or readmissions and its relation to frailty status.…”

Complex, high‐risk percutaneous coronary intervention types, trends, and in‐hospital outcomes among different age groups: An insight from a national registry

“…2 Age is one of the accepted criteria of how CHiP is defined, and is known to be an important predictor of worse PCI outcomes. 3 While there are no specific studies that have looked explicitly at CHiP outcomes according to age in the real-world setting, prior studies that have focused on individual CHiP components have suggested worse outcomes associated with older age in chronic renal failure (CRF), 4 PCI in chronic total occlusions (CTOs) 5,6 left main (LM) PCI, 7 or severe vascular calcification. 8 There have been no previous studies focused on whether the type of CHiP cases undertaken in different age groups varies by age, and whether the growth of CHiP and the types of cases undertaken has changed differentially among different age groups.…”

“… 2 Age is one of the accepted criteria of how CHiP is defined, and is known to be an important predictor of worse PCI outcomes. 3 While there are no specific studies that have looked explicitly at CHiP outcomes according to age in the real‐world setting, prior studies that have focused on individual CHiP components have suggested worse outcomes associated with older age in chronic renal failure (CRF), 4 PCI in chronic total occlusions (CTOs) 5 , 6 left main (LM) PCI, 7 or severe vascular calcification. 8 …”

Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA

“…Although no studies have directly examined CHiP outcomes according to age in the real-world setting, findings from studies focusing on specific CHiP types indicate poorer outcomes among older individuals. For instance, worst outcomes post-PCI were observed in those elderly patients with chronic renal failure 142 , those who underwent a CTO PCI 143,144 , those who received calcium modification therapy 145 , and those who underwent left main PCI 146 .…”