Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes

Ramakrishna, Rachumallu; Bhateria, Manisha; Singh, Rajbir; Bhatta, Rabi Sankar

doi:10.1016/j.jsbmb.2016.05.018

Cited by 15 publications

(1 citation statement)

References 40 publications

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“…In the flufenoxuron exposure group, the up-regulated Cyp1a mRNA level may be activated by the Ahr gene in the liver. As the Cyp1a gene is responsible to metabolize toxicants into less toxic metabolites (Ramakrishna et al, 2016), another speculation is that the increase of the Cyp1a gene expression may be a feedback effect to the high residua level of flufenoxuron in the liver at 168 h. The Cyp1a and Ahr genes can be used as a biomarker to evaluate the effect of BPUs on the hepatocytes.…”

Section: Groupmentioning

confidence: 99%

The tissue distribution, metabolism and hepatotoxicity of benzoylurea pesticides in male Eremias argus after a single oral administration

Chang

et al. 2017

Chemosphere

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Benzoylurea pesticides (BPUs) are widely used to control the locust, but the toxicokinetics and hepatotoxicity of BPUs in lizards have not been investigated. In this study, the tissue distribution, metabolism and liver toxicity of diflubenzuron and flufenoxuron were assessed in the Eremias argus following a single oral exposure. Diflubenzuron preferred to accumulate in the fat and brain (>1.0 mg kg) and was rapidly eliminate in other tissues. In the liver, 4-chloroaniline was one of diflubenzuron metabolites, although with a concentration less than 0.05% of the accumulated diflubenzuron. No significant difference was observed in the liver histopathology between the control and diflubenzuron exposure group. The expressions of Cyp1a and Ahr gene which control the cell apoptosis were also equal to the control level. After flufenoxuron exposure, biomodal phenomenon was observed in the liver, skin, brain, gonad, kidney, heart and blood circulation was an important route for the flufenoxuron penetration. The concentrations of flufenoxuron in all tissues were greater than 1.0 mg kg at 168 h. The excretion of flufenoxuron in the faeces was 1.5 fold higher than diflubenzuron. The hepatocytes in the flufenoxuron treated group showed vacuolation of cytoplasm and decreased nucleus. In addition, the Cyp1a and Ahr genes were significantly up-regulated in the flufenoxuron exposure group. These results suggested that the higher hepatotoxicity of flufenoxuron may be attributed to the higher residual level in the lizard tissues and the Cyp1a and Ahr genes can serve as biomarkers to assess the liver toxicity.

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Section: Groupmentioning

confidence: 99%

The tissue distribution, metabolism and hepatotoxicity of benzoylurea pesticides in male Eremias argus after a single oral administration

Chang

et al. 2017

Chemosphere

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Effect of Gambogenic Acid on Cytochrome P450 1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats

Sun

Tang

et al. 2018

Eur J Drug Metab Pharmacokinet

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The sub-chronic impact of mPEG2k-PCLx polymeric nanocarriers on cytochrome P450 enzymes after intravenous administration in rats

Sun

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes

Cited by 15 publications

References 40 publications

The tissue distribution, metabolism and hepatotoxicity of benzoylurea pesticides in male Eremias argus after a single oral administration

The tissue distribution, metabolism and hepatotoxicity of benzoylurea pesticides in male Eremias argus after a single oral administration

Effect of Gambogenic Acid on Cytochrome P450 1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats

The sub-chronic impact of mPEG2k-PCLx polymeric nanocarriers on cytochrome P450 enzymes after intravenous administration in rats

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