Evaluation of the<i>in vivo</i>Anti-inflammatory and Analgesic and<i>in vitro</i>Anti-cancer Activities of Curcumin and its Derivatives

Jacob, James N.; Badyal, Dinesh; Bala, Suman; Toloue, Masoud

doi:10.1177/1934578x1300800321

Cited by 22 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Curcumin is widely consumed, particularly in Asia, as one of the culinary ingredients in food recipes. In the recent years, this polyphenol has increasingly received worldwide attention for its multiple pharmacological activities, primarily anti-inflammatory and antioxidant ones [26][27][28][29]. A recent meta-analysis has evidenced curcumin efficacy as a free radical scavenger and an inhibitor of malondialdehyde production, showing its ability in improving levels of antioxidants in diseased individuals susceptible to oxidative stress.…”

Section: Curcumin: Metabolism and Bioavailabilitymentioning

confidence: 99%

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

2020

View full text Add to dashboard Cite

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries in traditional Asian medicine, and nowadays it is widely used in food as dietary spice worldwide. It has received considerable attention for its pharmacological activities, which appear to act primarily through anti-inflammatory and antioxidant mechanisms. For this reason, it has been proposed as a tool for the management of many diseases, among which are gastrointestinal and neurological diseases, diabetes, and several types of cancer. However, the pharmacology of curcumin remains to be elucidated; indeed, a discrepancy exists between the well-documented in vitro and in vivo activities of curcumin and its poor bioavailability and chemical instability that should limit any therapeutic effect. Recently, it has been hypothesized that curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of this polyphenol have been detected after oral administration. Consequently, it might be hypothesized that curcumin directly exerts its regulatory effects on the gut microbiota, thus explaining the paradox between its low systemic bioavailability and its wide pharmacological activities. It is well known that the microbiota has several important roles in human physiology, and its composition can be influenced by a multitude of environmental and lifestyle factors. Accordingly, any perturbations in gut microbiome profile or dysbiosis can have a key role in human disease progression. Interestingly, curcumin and its metabolites have been shown to influence the microbiota. It is worth noting that from the interaction between curcumin and microbiota two different phenomena arise: the regulation of intestinal microflora by curcumin and the biotransformation of curcumin by gut microbiota, both of them potentially crucial for curcumin activity. This review summarizes the most recent studies on this topic, highlighting the strong connection between curcumin and gut microbiota, with the final aim of adding new insight into the potential mechanisms by which curcumin exerts its effects.

show abstract

Section: Curcumin: Metabolism and Bioavailabilitymentioning

confidence: 99%

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

2020

View full text Add to dashboard Cite

show abstract

“…4.17) were synthesized, and their in vivo analgesic and antiinflammatory activities were compared with those of curcumin and aspirin. The percentage inhibition of paw edema was maximum for DAC, followed by aspirin and curcumin [65]. The inhibitory effects were comparable to each other and nearing that of curcumin, while they showed low inhibitory effect toward the noncancerous cell line.…”

Section: Anticancer Property Of Curcuminmentioning

confidence: 62%

Comparative Studies in Relation to the Structure and Biochemical Properties of the Active Compounds in the Volatile and Nonvolatile Fractions of Turmeric (C. longa) and Ginger (Z. officinale)

Jacob¹

2016

Studies in Natural Products Chemistry

View full text Add to dashboard Cite

“…Rats-treated with curcumin (100 mg/kg, p.o. ), an onset of action, and the peak analgesic effect were observed at 60 min and 90 min, respectively in the tail-flick test [ 52 ]. In the previous study, in acetic acid-induced writhing test, 10, 20, and 40 mg/kg of intraperitoneal administration of curcumin produced antinociception of 23, 26, 29%, respectively [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Co-administration of Pregabalin and Curcumin Synergistically Decreases Pain-Like Behaviors in Acute Nociceptive Pain Murine Models

et al. 2020

View full text Add to dashboard Cite

Analgesic drugs in a combination-form can achieve greater efficacy with lesser side effects compared to either drug alone. The combination of drugs acting at different targets or mechanisms of action has been recognized as an alternative approach for achieving optimal analgesia. In this study, the analgesic effects of pregabalin (30, 60, 100, 200 mg/kg), curcumin (15, 30, 60, 100, 120 mg/kg), and 1:1 fixed-dose ratio of the pregabalin-curcumin combination were assessed using two acute nociceptive pain models, the acetic acid-induced writhing and tail-flick tests in mice. The pregabalin-curcumin combination produced a dose-dependent decrease in mean of writhes and an increase in the percentage of antinociception by the acetic acid-induced writhing test. In the tail-flick test, the combination also showed an improvement in antinociception indicated by the tail-flick latency, % antinociception, and area under the curve (AUC). Isobolographic analysis of interactions demonstrated a significant synergistic interaction effect between pregabalin and curcumin in both acute nociceptive pain models with the experimental ED50 below the predicted additive line and the combination index < 1. These findings demonstrate that the combination of pregabalin and curcumin exhibits a synergistic interaction in mouse models of acute nociceptive pain.

show abstract

Evaluation of thein vivoAnti-inflammatory and Analgesic andin vitroAnti-cancer Activities of Curcumin and its Derivatives

Cited by 22 publications

References 10 publications

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Comparative Studies in Relation to the Structure and Biochemical Properties of the Active Compounds in the Volatile and Nonvolatile Fractions of Turmeric (C. longa) and Ginger (Z. officinale)

Co-administration of Pregabalin and Curcumin Synergistically Decreases Pain-Like Behaviors in Acute Nociceptive Pain Murine Models

Contact Info

Product

Resources

About