Evaluation of the humoral response of meningioma patients to possible common tumour-associated antigens

Mottet, S.; Martin-Achard, A; Tribolet, N. de; Diserens, A.-C.

doi:10.1007/bf01400942

Cited by 5 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our hypothesis is supported by the fact that CNS tumours are capable of inducing a complex immunological response to the host (Mottet et al 1980). Moreover, the sera of post-operative meningioma patients, when assessed with 3H proline microcytotoxicity tests, is positive for specific cell-mediated cytotoxicity on meningioma cells, fact which strongly supports the immunological properties of meningiomas (Pees & Seidel 1976).…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Co-occurrence of brain tumours and demyelination of the central nervous system: coincidence or interrelation?

Polychronopoulos

Partheni

Konstantinou

et al. 2008

European Journal of Cancer Care

View full text Add to dashboard Cite

The co-occurrence of a brain tumour and demyelinating disease of the central nervous system (CNS) constitutes a rare clinical entity. We herein report the incidence of meningioma and CNS non-specific demyelination in a patient with a 6-year history of operated brain tumour (meningioma). Our case bolsters the argument that in at least some cases, the occurrence of a brain tumour could predispose to CNS non-specific demyelination.

show abstract

Section: Discussionsupporting

confidence: 69%

“…Our hypothesis is supported by the fact that CNS tumours are capable of inducing a complex immunological response to the host (Mottet et al. 1980).…”

Section: Discussionmentioning

confidence: 60%

Co-occurrence of brain tumours and demyelination of the central nervous system: coincidence or interrelation?

Polychronopoulos

Partheni

Konstantinou

et al. 2008

European Journal of Cancer Care

View full text Add to dashboard Cite

show abstract

Electron-microscopic visualization of binding of antibodies from sera of glioma patients on cultured glioma cells

Lauro¹,

C²,

Medolago-Albani

et al. 1983

Acta Neuropathol

View full text Add to dashboard Cite

Several human cell lines (normal and neoplastic glia, cerebral metastases from adenocarcinoma, fibroblasts) were incubated with sera from patients with well and poorly differentiated glioma and with sera from healthy donors and then stained with PAP complex to define and localize the antibody reaction with cell surface antigens by means of electron microscopy. The sera of glioma patients proved to contain antibodies which bound the tumor-associated antigenic determinants on the cell membranes of gliomas and of cerebral metastases from adenocarcinoma in tissue cultures. Further, absorption testing of the reactive sera on normal brain, well-differentiated astrocytoma and cultured glioblastoma cells, together with cross-reactivity experiments suggests that at least two antigens or groups of antigens are expressed on the glioma cell surface: one shared by well and poorly differentiated glioma cells and the other by poorly differentiated glioma cells and the cells of cerebral metastases from adenocarcinoma.

show abstract

The utilization of native glioma antigens in the assessment of cellular and humoral immune responses in malignant glioma patients

et al. 1981

View full text Add to dashboard Cite

Cellular and humoral components of the immune response have been studied preoperatively, concurrently, and serially in patients with malignant glial neoplasms. In order to assess titres of circulating antibodies to tumour cell constituents an indirect immunofluorescent technique was applied to single cell suspensions and snap frozen cell smears. In an allogeneic system, 49% of 47 test and 7% of 124 control sera gave a positive response to cytoplasmic components. The leucocyte adherence inhibition assay was applied to study 39 test and 64 control patients. Significant non-adherence of leukocytes was observed in 77% of test cases. Control parameters indicated specificity of the response. Simultaneous assessment in 28 test patients yielded a positive response for one or both assays in 89% of cases..

show abstract

Evaluation of the humoral response of meningioma patients to possible common tumour-associated antigens

Cited by 5 publications

References 9 publications

Co-occurrence of brain tumours and demyelination of the central nervous system: coincidence or interrelation?

Co-occurrence of brain tumours and demyelination of the central nervous system: coincidence or interrelation?

Electron-microscopic visualization of binding of antibodies from sera of glioma patients on cultured glioma cells

The utilization of native glioma antigens in the assessment of cellular and humoral immune responses in malignant glioma patients

Contact Info

Product

Resources

About