Evaluation of the Human Pulmonary Activation-Regulated Chemokine (CCL18/PARC) and Alkaline Phosphatase (ALP) Levels in Iraqi Patients with Rheumatoid Arthritis

Al-Hashimi, Nawal Haider; Al-Gebori, Abdulnasser M.; Alosami, Mohammed H.

doi:10.24996/ijs.2020.61.4.1

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…The hypoxia modulation cellular bioenergetics by inducing dysfunction of mitochondrial and promoting a switch to glycolysis, that leading to abnormal angiogenesis [30]. The current study agrees with a previous report which recorded significantly elevated serum levels of biomarkers in RA patients than those in the control group (p≤0.001) [31].…”

Section: Discussionsupporting

confidence: 92%

The Evaluation of Some Biomarkers According to Rheumatoid Factor in Early Diagnosis of Rheumatoid Arthritis from Iraqi Patients

Hassoon

Jasim

Abbas

2020

eijs

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Rheumatoid arthritis (RA) was a chronic inflammatory autoimmune disease for long-term that primarily affects small joints and leads to chronic inflammation in synovial. The aimed of the study to identify the relationships among some serological markers (antibodies to citrullinated protein/peptide antigens (ACPAs), anti-mutated citrullinated vimentin (anti-MCV), anti-carbamylated protein (Anti-Carp), anti- heterogeneous nuclear ribonucleoproteins (anti-hnRNP) and Glucose-6-phosphate isomerase (GPI)) and early diagnosis of RA. The study involved (60) Patients of newly diagnosis with RA that divided in to two subgroups (30 RF positive and 30 RF negative) groups and 30 subjects as healthy control group. The serological data from serum concentration of (ACPAs, Anti-MCV, Anti-Carp, Anti-hnRNP, G6PI) estimated by ELISA methods, RF estimated by latex agglutination kits. The results revealed that ACPAs, Anti-MCV, Anti-Carp, Anti-hnRNP, G6PI having a statistical significants at the mean±SD titer different between the two RF groups, a higher value among the refractory RA patients in comparison with the control group. Also effectively distinguishing RA patients groups for RF+ve and RF-ve with showed the sensitivity and specificity of, ACPAs (90.8% , 94.1%, and 88.2%, 86.6%); anti-MCV (66.7% , 33.0% and 70.0%, 70.2%); anti-CarP (76.7% , 90.0% and 93.3%, 78.5%); anti-hnRNP (74.9% , 61.9% and 71.4%, 70.9%) and GPI (77.3% , 76.7% and 84.4%, 80.1%) respectively. This study confirm the importance of measuring multiple serum biomarkers and their combinations with high diagnostic value for RA and provide support for the early diagnosis of RA.

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Section: Discussionsupporting

confidence: 92%

The Evaluation of Some Biomarkers According to Rheumatoid Factor in Early Diagnosis of Rheumatoid Arthritis from Iraqi Patients

Hassoon

Jasim

Abbas

2020

eijs

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“…During hypoxia related anemia, mediators such as PDGF-BB, which is released by different cell types, suppress hepcidin. Hepcidin levels are decreased by a special mechanism in low-risk myelodysplasia with ringed sideroblasts, a clonal disorder due to mutations of the spliceosome gene SF3Bl 51 . Scientists revealed that iron accumulation in the mitochondria, could lead to ineffective erythropoiesis and systemic iron overload.…”

Section: Discussionmentioning

confidence: 99%

الهيبسيدين وبعض المتغيرات البيوكيميائية في الأطفال العراقيين الذين يعانون من نقص هرمون النمو

Ali,

Alfatlawi,

Algebori

et al. 2024

Baghdad Sci.J

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Hepcidin (Hep.) is a protein that maintains iron balance in the body. The Information about the role of Hep. in pathophysiology that is associated with growth hormone deficiency (GHD) is scarce. This study evaluates the correlation of Hep. with some biochemical parameters: Growth Hormone (GH), Insulin-Like Factor-1 (IGF-1), Iron, Vitamin D, Alkaline Phosphatase (ALP), Calcium, Phosphorous, and Ferritin in growth hormone deficient children. Children with GHD (60) and healthy volunteers (60) participated in this study, and their serum samples are collected from National Diabetes Center- Almustansirya University from the period January to April 2022. Enzyme Linked Immune Sorbent Assay (ELIZA) is used to measure Hep. while Chemiluminescence immunoassay is to measure GH and IGF-1.Results demonstrate significant decrease of p<0.01 in the Hep. level in the sera of GHD patients when compared to healthy individuals, and iron levels increase. This can be explain the inverse relationship between hepcidin and iron .It is an important regulator of iron absorption, this mechanism through Hep. preventive any impact against anemia by increasing the bioavailability of (Fe). Therefore, this study is carried out to give a better understanding about the parameters that affect the children with GHD and Hep. that can be a dependable parameter for better management of those children.

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“…Through a variety of mechanisms, TN-C promotes both adaptive and innate immune responses in arthritic joints. TN-C's C-terminal gFG induces the pro-inflammatory cytokines and chemokines release in autoimmune disease patients such as RA [10], which increases the risk of osteoporosis around the afflicted joint, erosive synovitis, bone damage, and cartilage deterioration [11,12].…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C and Interleukin-17 Up-regulation in Axial Spondyloarthritis Patients

Al-Hindawi¹,

Al-Gebori²,

Alosami³

2023

RBJ

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Background: Axial spondyloarthritis (axSpA) is an inflammatory, systemic rheumatic condition that mostly affects the axial skeleton. Tenascin-C (TN-C) is a hexameric glycoprotein of considerable size, upregulated in many inflammatory conditions, while Interleukin-17 (IL-17) a cytokine that plays an important role in SpA symptoms. Objective: to investigate the upregulation between the serum levels of TN-C and IL-17 in Iraqi axSpA patients and the disease characteristics. Patients and Methods: Seventy-four axSpA patients and 28 matched controls were studied. Fifty-four patients received a tumor necrosis factor inhibitor (TNFi) and 20 did not. Serum TN-C and IL-17 concentrations were determined using the ELISA technique. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was assessed. For statistical tests, Chi Square, Mann Whitney, Independent Samples T, and Pearson's correlation tests are used. Results: Patients mean age was 35.6±0.9 years, 65 males and 9 females, and disease duration was 5.18±0.6 years. 47.4% were smokers, 47% had inflammatory low back pain, and HLA-B27 was present in 91%. BASDAI mean was 6.1±0.4 in non-TNFi and 2.6±0.3 in those on TNFi. The serum TN-C concentration was significantly increased in patients, especially those on non-TNFi (79±9.6 pg/mL) compared to those on TNFi (69.1±3.2 pg/mL) and control (53±3.9 pg/mL) (p=0.003). Serum IL-17 was significantly elevated in those receiving TNFi (877.9±257 pg/mL) compared to non-TNFi (487.2±234 pg/mL) and control (182.4±36.6 pg/mL) (p=0.033). The TN-C significantly correlated with erythrocyte sedimentation rate (r=0.27, p=0.02) and with hemoglobin (Hb) concentration (r=0.26, p=0.02). TN-C and IL-17 were non-significantly related (r=0.14, p=0.2). Conclusions: axSpA Patients demonstrated high levels of serum TN-C, particularly in those not receiving TNFi, and high IL-17 levels in those receiving TNFi, suggesting that there is an association with tissue injury from the disease and stimulation of immunological and resident tissue cells. Patients who had not received TNFi showed significantly higher disease activity than others.

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Evaluation of the Human Pulmonary Activation-Regulated Chemokine (CCL18/PARC) and Alkaline Phosphatase (ALP) Levels in Iraqi Patients with Rheumatoid Arthritis

Cited by 5 publications

References 15 publications

The Evaluation of Some Biomarkers According to Rheumatoid Factor in Early Diagnosis of Rheumatoid Arthritis from Iraqi Patients

The Evaluation of Some Biomarkers According to Rheumatoid Factor in Early Diagnosis of Rheumatoid Arthritis from Iraqi Patients

الهيبسيدين وبعض المتغيرات البيوكيميائية في الأطفال العراقيين الذين يعانون من نقص هرمون النمو

Tenascin-C and Interleukin-17 Up-regulation in Axial Spondyloarthritis Patients

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