2021
DOI: 10.1007/s00192-021-04851-6
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Evaluation of the histological and biomechanical properties of poly-4-hydroxybutyrate scaffold for pelvic organ prolapse, compared with polypropylene mesh in a rabbit model

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Cited by 4 publications
(5 citation statements)
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“…The Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) has recommended the identification of alternatives to PP, with a focus on biodegradable biomaterials to reduce the risk of long-term complications. 9 Poly-4-hydroxybutyrate (P4HB) has been identified as a candidate material for vaginal POP surgery, 10,11 with the hypothesis that a delayed absorbable scaffold will provide mechanical support while being gradually replaced by functional connective tissue. P4HB is a biologically produced biosynthetic polymer 12 that degrades to the human metabolite 4HB 13 before being eliminated from the body completely.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) has recommended the identification of alternatives to PP, with a focus on biodegradable biomaterials to reduce the risk of long-term complications. 9 Poly-4-hydroxybutyrate (P4HB) has been identified as a candidate material for vaginal POP surgery, 10,11 with the hypothesis that a delayed absorbable scaffold will provide mechanical support while being gradually replaced by functional connective tissue. P4HB is a biologically produced biosynthetic polymer 12 that degrades to the human metabolite 4HB 13 before being eliminated from the body completely.…”
Section: Introductionmentioning
confidence: 99%
“…Poly‐4‐hydroxybutyrate (P4HB) has been identified as a candidate material for vaginal POP surgery, 10,11 with the hypothesis that a delayed absorbable scaffold will provide mechanical support while being gradually replaced by functional connective tissue. P4HB is a biologically produced biosynthetic polymer 12 that degrades to the human metabolite 4HB 13 before being eliminated from the body completely.…”
Section: Introductionmentioning
confidence: 99%
“…Fourteen publications identified by this scoping review involved preclinical studies in a variety of animal models and species, including pigs, rats, rabbits, sheep, mice, and vervets (Figure 2, and Table 1) (6,23,24,26,36,37,(43)(44)(45)(46)(47)(48)(49)89). Three of these studies (n = 3) contained both a benchtop component and a preclinical component (6,36,37).…”
Section: Resultsmentioning
confidence: 99%
“…In the area of plastic and reconstructive surgery, P4HB mesh has been used primarily in breast surgery (13)(14)(15)(16)(17)(18)(19)(20)(21), with some early work in rhytidectomy (16,22). P4HB mesh has also been evaluated as a potential biomaterial for the repair of pelvic organ prolapse in urogynecological surgery (23)(24)(25)(26). The majority of data and clinical research using P4HB mesh has focused on general surgery applications, particularly in the area of hernia repair (i.e., ventral/incisional hernia, incisional hernia prophylaxis, inguinal hernia, and hiatal/paraesophageal hernia) (27)(28)(29)(30)(31).…”
Section: Introductionmentioning
confidence: 99%
“…Previous research in other animal models showed varying results. In a sheep model P4HB demonstrated increased inflammation and decreased vascularization as compared to PP at 60 and 180 days [ 25 ], whereas in a rabbit model no significant differences were found after 3 and 9 months for inflammation, neovascularization and elastin and collagen deposition around both materials [ 48 ].…”
Section: Discussionmentioning
confidence: 99%