Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model
Shu-Yan Gao,
Jing-Cheng Zhao,
Qing Xia
et al.
Abstract:Objective:Psoralea corylifolia L. (FP) has received increasing attention due to its potential hepatotoxicity.Methods: In this study, zebrafish were treated with different concentrations of an aqueous extract of FP (AEFP; 40, 50, or 60 μg/mL), and the hepatotoxic effects of tonicity were determined by the mortality rate, liver morphology, fluorescence area and intensity of the liver, biochemical indices, and pathological tissue staining. The mRNA expression of target genes in the bile acid metabolic signaling p… Show more
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