Evaluation of the hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima

Lin, Chun‐Ching; Yen, Ming‐Hong; Lo, T.S.; Lin, Jer-Min

doi:10.1016/s0378-8741(97)00122-0

Cited by 73 publications

(48 citation statements)

References 21 publications

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“…It has traditionally been used to treat several diseases, including wound healing. Although B. nivea has been shown to have antifungal and antioxidant properties (Lin et al, 1998;Xu et al, 2011), its other biological functions with respect to disease control are poorly understood. Thus, we first evaluated the effects of B. nivea on LPS-induced secretions of nitrate, TNF-a and IL-6 in RAW264.7 macrophages.…”

Section: Introductionmentioning

confidence: 99%

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

Sung

Davaatseren

Kim

et al. 2013

Pharmaceutical Biology

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Context: Boehmeria nivea (Linn.) Gaudich (Urticaceae), a natural herb, has a long history of treating several diseases including wound healing. However, the anti-inflammatory effect of B. nivea has not been investigated. Objective: We investigated whether the 70% ethanol extract of B. nivea (Ebn) can exert antiinflammatory activity. Several phenolic compounds of extracts were determined to provide further information on the correlation between anti-inflammatory effects and phenolic compounds. Materials and methods: We prepared a 70% ethanol extract of B. nivea leaves and evaluated its anti-inflammatory activity (200, 400, 800, 1200 mg/mL) by measuring the secretions of nitric oxide (NO), tumor necrosis factor alpha (TNF-a) and interleukin 6 (IL-6), which were stimulated by lipopolysaccharide (LPS) in RAW264.7 macrophages. The total phenolic compounds were determined by the Folin-Ciocalteu method and major compounds were determined by HPLC. Results: Ebn was able to abolish the LPS-induced secretions of NO, TNF-a and IL-6. It also decreased the protein levels (IC 50 ¼ 186 mg/mL) of LPS-induced inducible nitric oxide synthase (iNOS). The LPS stimulated p38, JNK and ERK phosphorylations significantly more than the controls. Surprisingly, although Ebn reduced p38 and JNK phosphorylations, it did not influence ERK phosphorylation. We found that Ebn revealed several major compounds such as chlorogenic acid (1.96 mg/100 g), rutin (46.48 mg/100 g), luteolin-7-glucoside (11.29 mg/100 g), naringin (1.13 mg/100 g), hesperidin (23.69 mg/100 g) and tangeretin (1.59 mg/100 g). Discussion and conclusion: Boehmeria nivea exerts an anti-inflammatory effect on macrophages by inhibiting p38 and JNK, suggesting that it may be used as a functional ingredient against inflammation.

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Section: Introductionmentioning

confidence: 99%

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

Sung

Davaatseren

Kim

et al. 2013

Pharmaceutical Biology

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“…However, several studies suggest that some herbal plants such as Spirulina maxima (Torres -Durain et al, 1999), Eclipta alba (Saxena et al, 1993), Boehmeria nivea (Lin et al, 1998), Cichorium intybus (Zafar and Ali, 1998), Picrorhiza kurrooa (Saraswat et al, 1999), Trianthema decandra (Balamurugan and Muthusamy, 2008), and Phyllanthus niruri (Iqbal et al, 2007) etc. have hepatoprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

Thakare

Jain

Patil

et al. 2009

Bangladesh J Pharmacol

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In this animal model (Wistar rats of either sex), common bile duct was ligated for 28 days. Rats were treated for 28 days with methanol extract of Cocculus hirsutus. On day 29, blood and liver were collected for biochemical estimation and histopathological studies. Bile duct ligation produced liver fibrosis with generation of reactive oxygen species and induction of oxidative stress. Hence the different concentrations of methanolic extract of C. hirsutus were evaluated for in vivo glutathione reductase activity. On bile duct ligation the liver fibrosis was induced with significant rise in serum marker enzymes levels. The hydroxyproline accumulation caused by hydrophilic bile acids accompanied by elevated hepatic lipid peroxidation, and glutathione levels. Treatment with C. hirsutus extract decreased the elevated levels of serum marker enzymes showing hepatoprotection, which was further confirmed by histopathological results. Article Info

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“…Lipid peroxidation was determined by measuring the concentration of malondialdehyde (MDA) in rat liver homogenate using the thiobarbituric acid (TBA) reactive species assay according to methods by Ohkawa et al (1979) and Lin et al (1998). LPO inhibition (percent) was calculated according to the following equation (Toda et al 2000).…”

Section: Determination Of Lipid Peroxidation Inhibition Percentmentioning

confidence: 99%

Effect of amurca on olive oil quality during storage

et al. 2013

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Total phenolic compounds (TPC), antioxidant activity (AA), lipid peroxidation inhibition (percent) (LPOIP), free fatty acid and peroxide values were measured in olive oil samples over the period of 12 months in comparison with oil samples extracted from amurca (olive oil lees) and olive oil samples taken from the bottom of the canister (near amurca) after 12 months of storage. Olive oil samples taken over the period of 12 months possessed decreasing amounts of TPC, AA and LPOIP, which led to increased peroxide and free fatty acid values. In contrast, oil extracted from amurca and olive oil samples taken from the bottom of the container after 12 months of storage possessed significantly higher TPC, AA, LPOIP and consequently lower free fatty acid and peroxide values. These results show that the presence of naturally occurring amurca (sediment) in stored olive oil stabilizes olive oil quality during storage.

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Evaluation of the hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima

Cited by 73 publications

References 21 publications

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

Effect of amurca on olive oil quality during storage

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