Evaluation of the hematoprotective and hepato-renal protective effects of Thymus vulgaris aqueous extract on thermally oxidized oil-induced hematotoxicity and hepato-renal toxicity

Abdallah, Amany A. M.; El-Deen, Nasr A.M. Nasr; Neamat‐Allah, Ahmed N. F.; El-Aziz, Heba I. Abd

doi:10.1007/s00580-019-03078-8

Cited by 29 publications

(19 citation statements)

References 53 publications

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“…Some of the modern anticancer drugs such as vincristine and vinblastine are plantbased (Wangchuk 2018). Experimental evidence in animal models revealed that plant extracts have a wide variety of beneficial effects including immunomodulation, hepatoprotection, and renoprotection (Abdallah et al 2019;Hashem et al 2019;Neamat-Allah et al 2020;El-Murr et al 2019). According to the mentioned observations, herbal extracts provide a promising tool for the treatment of some health treating diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Extractions from different parts of the plants have been utilized for therapeutical uses. For example, Thymus vulgaris aqueous extract has a hepato-protective and reno-protective effect in oxidized oil-induced toxicity (Abdallah et al 2019). Researchers demonstrated that some natural products have immunomodulating effects and can be used as a supplement against infection (Hashem et al 2019;Neamat-Allah et al 2020;El-Murr et al 2019).…”

Section: Introductionmentioning

confidence: 99%

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Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

et al. 2020

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Gentamicin (GM) is an effective antibiotic against gram-negative bacterial infection. However, GM can produce nephrotoxicity. Stachys lavandulifolia Vahl. (SL) is extensively used in folk medicine as herbal tea and has strong antioxidative effects. The aim of this study was to investigate the protective effect of SL on GM-induced nephrotoxicity in rats. In this study, forty-two male Wistar rats were randomly divided into six equal groups (N = 7 each): control (group I), GM-treated (group II), SL200 mg/kg + GM-treated (group III), SL400 mg/kg + GM-treated (group IV), SL200 mg/kg-treated (group V), and SL400 mg/kg-treated (group VI) groups. The treatment procedures continued for 10 days. At the end of the experiment, serum and the kidneys of all groups were harvested for histological and biochemical examination. No statistical significant improvement in histological and biochemical indices was shown at 200 mg/kg of SL treatment in group III compared with group II; however, at 400 mg/kg of SL, normalized serum levels of uric acid (P < 0.001), urea (P < 0.001), creatinine (P < 0.01), and total proteins (P < 0.05) were shown in group IV. Treatment with SL400 mg/kg also corrected the increased relative kidney weight in GM-treated animals (P < 0.05). GM nephrotoxicity was shown by elevated levels of malondialdehyde (P < 0.001) and decreased amounts of catalase (P < 0.001), superoxide dismutase (P < 0.01), and glutathione (P < 0.01) in renal tissue. The oxidative injury induced by GM was prevented by SL400 mg/kg treatment. Such treatment also normalized abnormal renal histology induced by GM. These data suggest that treatment with SL extract may be helpful to reduce gentamicin-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

et al. 2020

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“…Recently, the use of natural ingredients as immunomodulators for enhancing resistance and immunity in various live organisms has been proposed (Abdallah, Nasr El‐Deen, Neamat‐Allah, & Abd El‐Aziz, ; Badr et al, ; Hashem, Neamat‐Allah, Hammza, & Abou‐Elnaga, ; Neamat‐Allah, El‐Murr, & Abd El‐Hakim, ; Neamat‐Allah, Mahmoud, & Abd El Hakim, ; Prasanna, Ashraf, & Essam, ). β‐glucan (βG) is known as natural immunomodulator.…”

Section: Introductionmentioning

confidence: 99%

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

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“…Complete blood count revealed the cat was having mild macrocytic normochromic anaemia (6.07, RR 6.5–10.0, 10 6 /μl), neutrophilia (16.7, RR 2.0–8.0, 10 3 /μl), lymphopenia (3.2, RR 5.7–8.9, 10 3 /μl), monocytopenia (0.3, RR 2.2–4.0, 10 3 /μl) and thrombocytosis (1143, RR 300–800, 10 3 /μl) (Abdallah et al 2020a , b ; Neamat-Allah et al 2020 ). The serum biochemistry showed hypoproteinaemia (4.0, RR 5.7–8.9 g/dl) and elevated urea (50, RR 16–36, mg/dl) and creatinine (5.3, RR 0.8–2.4, mg/dl) parameters (Abdallah et al 2020a , b ). The cat was treated with antibiotics; enrofloxacin (5 mg/kg) and metronidazole (10 mg/kg), nonsteroidal anti-inflammatory drugs; meloxicam (0.3 mg/kg), gastric protectant; ranitidine (2.5 mg/kg), gastrointestinal absorbent; kaolin-pectin, iron supplement; and vitamin B complex supplements.…”

Section: Case Historymentioning

confidence: 99%

Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case report

et al. 2020

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Feline polycystic kidney disease (PKD) is an inherited disorder caused by the mutation of PKD1 gene that eventually lead to the development of chronic kidney disease. The latter condition causes hypertension and eventually progress into congestive heart failure. Feline parvovirus (FPV) is a highly contagious and often fatal disease infecting cats and other members of Felidae. An 8-month-old female domestic shorthair cat was presented with complaint of wound dehiscence a day after ovarian hysterectomy procedure. The wound at the suture site appeared necrotic, purulent with foul smell. The cat was found to have diarrhoea during the fixation of suture breakdown and, later, was tested positive with parvovirus infection. Complete blood count revealed anaemia, neutrophilia, lymphopenia and thrombocytosis. Biochemistry profiles showed hypoproteinaemia and elevated of urea and creatinine. The cat was hospitalised, and symptomatic treatments were given. During hospitalisation, the cat showed symptoms of polydipsia and polyuria and found dead 2 days later. Post-mortem findings demonstrated the cat had oral ulceration, thoracic effusion, fibrinopleuropneumonia, pericardial effusion, left ventricular hypertrophy and right ventricular dilation, chronic passive liver congestion, mesenteric lymphadenomegaly, intestinal haemorrhage, adrenomegaly and polycystic kidney. Histopathological evaluation revealed fibrinous pleuropneumonia, pulmonary atelectasis, emphysema and oedema, hypertrophic cardiomyopathy, hepatic necrosis, splenic necrosis, intestinal necrosis, renal necrosis and renal polycystic. Staphylococcus aureus and Escherichia coli were isolated from bronchus swab and intestinal segment, respectively. Polymerase chain reaction (PCR) revealed parvovirus infection. The cat was definitely diagnosed with polycystic kidney disease concurrent with parvoviral and secondary bacterial infections.

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Evaluation of the hematoprotective and hepato-renal protective effects of Thymus vulgaris aqueous extract on thermally oxidized oil-induced hematotoxicity and hepato-renal toxicity

Cited by 29 publications

References 53 publications

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

Preventive effect of Stachys lavandulifolia against gentamicin-induced oxidative stress and nephrotoxicity in rats

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case report

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