Evaluation of the genotoxic potential of Bauhinia monandra leaf lectin (BmoLL)

Genotoxicity Evaluation of Moringa oleifera Seed Extract and Lectin

“…The Salmonella assay is a method used worldwide for mutagenic analysis. Thus, the choice of strains was based on published studies with plant‐derived products (Marques and others 2003; Carvalho and others 2003; Santos and others 2008; Sisenando and others 2009). According to Mortelmans and Zeiger (2000) the mutation in the gene hisG428 that occurs in TA102 is an ocher mutation, TAA, which can be reversed by transition or transversion through exposure to oxidizing agents.…”

Genotoxic and mutagenic properties of Bauhinia platypetala extract, a traditional Brazilian medicinal plant

“…Our data in fact showed that B. platypetala induced DNA damage in V79 cells up to a 50 mg/mL concentration (Table 5). Similarly, evaluation of the genotoxic potential of the Bauhinia monandra leaf showed no increase in the frequency of reverse mutations in Salmonella typhimurium strains (TA97, TA98, TA100 and TA102), both with and without metabolic activation (Sisenando et al, 2009). B. forficata extract was able to induce mutagenesis in the TA102 strain (Bresolin and Vargas, 1993), and studies have reported that B. galpinii has antimutagenic potential (Aderogba et al, 2007;Reid et al, 2006).…”

Phytochemical study and evaluation of cytotoxicity, mutagenicity, cell cycle kinetics and gene expression of Bauhinia holophylla (Bong.) Steud. in HepG2 cells in vitro

“…ex Benth., showed no cytotoxic effects in S. cerevisiae, but increased DNA damage in mammalian V79 cells (Santos et al 2012). Components of the leaves of Bauhinia monandra Kurz did not affect the frequency of reverse mutations in strains of Salmonella typhimurium (TA97, TA98, TA100 and TA102) with and without metabolic activation (Sisenando et al 2009). The extract of barks of Bauhinia variegata L. showed chemopreventive effects both in vitro (HEp2 and HBL-100 cells lines) and in vivo (Swiss albine mice) (Rajkapoor et al 2006;Agrawal and Pandey 2009;Pandey and Agrawal 2010).…”

“…Medicines and herbal compounds are popularly presumed as safe for human consumption without any adverse effect on health and, therefore, they are used in self-medication without medical prescription (Obici et al 2008). However, literature data demonstrate that substances in medicinal preparations may have toxic effects, including DNA damage (Verschaeve et al 2004;Sisenando et al 2009;Rodeiro et al 2014). The detection and evaluation of potential damages caused by plant compounds are of fundamental importance for minimizing adverse effects of plant extracts, specially when they are used in long-term treatments (Cardozo et al 2006).…”