Evaluation of the genetic association between early-onset primary angle-closure glaucoma and retinitis pigmentosa

et al. 2021

Preprint

Background To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China.Methods The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determined the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities.Results Nyctalopia (58.2%) and blurred vision (27.1%) were the leading reasons for RP patients to request an ophthalmic examination. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were macular abnormalities (59.7%) and cataracts (43.1%). The macular abnormalities included epiretinal membranes (51.1%), cystoid macular edema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes (p=0.001) and macular holes (p=0.008) increased significantly with age. Cystoid macular edema was significantly associated with poorer visual acuity in RP patients with clear lens (p=0.002).Conclusion Cataracts and macular abnormalities are common in RP patients. Of the macular abnormalities, cystoid macular edema may have a negative effect on BCVA in RP patients with clear lens. Therefore, optical coherence tomography screening in RP patients is highly recommended for early detection and treatment of maculopathy.

Section: Discussionsupporting

confidence: 61%

Ocular abnormalities in a large patient cohort with Retinitis Pigmentosa in Western China

et al. 2021

Preprint

“…In our study, the prevalence of glaucoma was 2%, lower than the 11.5% reported by Onakpoya et al [2]. and the 7.5% reported in Eballe et al [27], but similar to the prevalence in the general population (2-3%) [13]. The reason for the lower rate may be due to our larger sampled cohort and our study being retrospective study.…”

Section: Discussioncontrasting

confidence: 59%

“…Glaucoma is another ocular abnormality prevalent among RP subjects. There is some evidence to suggest similar genetic backgrounds for glaucoma and RP [13,25]. Ko YC et al reported a 3.64-fold greater odd of developing PACG in patients with RP than in the general population [26].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ocular abnormalities in a large Western China patient cohort with Retinitis Pigmentosa

et al. 2020

Preprint

Background: To report the prevalence of ocular abnormalities and investigate visual acuity in a large Western China cohort of retinitis pigmentosa (RP) patients.Methods: A retrospective study was performed, reviewing the medical records and ophthalmic examination reports of 2,127 eyes from 1,065 RP patients in one eye hospital. The authors investigated the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities.Results: Nyctalopia (58.2%) and blurred vision (27.1%) were the leading consultation causes. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were cataracts (43.1%) and macular abnormalities (59.7%), including epiretinal membranes (51.1%), cystoid macular oedema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes (P = 0.001) and macular holes (P = 0.008) increased significantly with age. The proportions of vitreomacular traction syndrome (P = 0.003) and epiretinal membranes (P < 0.001) in pseudophakia and aphakia eyes were significantly higher than in eyes that had not received operations (including cataracts and clear lens). Cystoid macular oedema was significantly associated with poorer visual acuity in RP patients with clear lens (P = 0.002).Conclusion: Cataracts and macular abnormalities are common in RP patients. In the macular abnormalities, cystoid macular oedema may have a negative effect on BCVA in RP patients with clear lens.

“…The lens condition was classi ed as clear, cataract, pseudophakic or aphakic. A specialist diagnosed glaucoma based on the presence of glaucomatous optic neuropathy and intraocular pressure over 21 mmHg, with or without the presence of iridotrabecular contact [12]. The macular microstructure was examined with Spectral Domain OCT (SD-OCT) (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin California, USA) or Heidelberg Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany).…”

Section: Imaging Examinationmentioning

confidence: 99%

Ocular abnormalities in a large patient cohort with Retinitis Pigmentosa in Western China

et al. 2020

Preprint

Background To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. Methods The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determined the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities. Results Nyctalopia (58.2%) and blurred vision (27.1%) were the leading reasons for RP patients to request an ophthalmic examination. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were macular abnormalities (59.7%) and cataracts (43.1%). The macular abnormalities included epiretinal membranes (51.1%), cystoid macular edema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes ( p =0.001) and macular holes ( p =0.008) increased significantly with age. Cystoid macular edema was significantly associated with poorer visual acuity in RP patients with clear lens ( p =0.002). Conclusion Cataracts and macular abnormalities are common in RP patients. Of the macular abnormalities, cystoid macular edema may have a negative effect on BCVA in RP patients with clear lens. Therefore, optical coherence tomography screening in RP patients is highly recommended for early detection and treatment of maculopathy.