Evaluation of the friction coefficient, the radial stress, and the damage work during needle insertions into agarose gels

Urrea, F.; Casanova, Fernando; Orozco, Gustavo A.; García, José Jaime

doi:10.1016/j.jmbbm.2015.11.024

Cited by 29 publications

(10 citation statements)

References 36 publications

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“…Similarly, a minimum stretch ratio of 0.455 was found with an insertion speed of 0.2 mm/s in a rat brain 53 . However, we used an insertion speed of ∼13 mm/s in the experiments, and increased insertion speed has been shown to increase radial stress in agarose by 226% when comparing an insertion rate of 1.8 mm/s to a rate of 10 mm/s, 54 suggesting that the stretch ratio in our experiments should be significantly less than those previously found in agarose.…”

Section: Discussionmentioning

confidence: 88%

Convection‐enhanced delivery with controlled catheter movement: A parametric finite element analysis

Mehta

Rausch

Rylander

2022

Numer Methods Biomed Eng

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Convection‐enhanced delivery (CED) is an investigational method for delivering therapeutics directly to the brain for the treatment of glioblastoma. However, it has not become a common clinical therapy due to an inability of CED treatments to deliver therapeutics in a large enough tissue volume to fully saturate the target region. We have recently shown that the combination of controlled catheter movement and constant pressure infusions can be used to significantly increase volume dispersed (Vd) in an agarose gel brain tissue phantom. In the present study, we develop a computational model to predict Vd achieved by various retraction rates with both constant pressure and constant flow rate infusions. An increase in Vd is achieved with any movement rate, but increase in Vd between successive movement rates drops off at rates above 0.3–0.35 mm/min. Finally, we found that infusions with retraction result in a more even distribution in concentration level compared to the stationary catheter, suggesting a potential increased ability for moving catheters to have a therapeutic impact regardless of the required therapeutic concentration level.

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Section: Discussionmentioning

confidence: 88%

Convection‐enhanced delivery with controlled catheter movement: A parametric finite element analysis

Mehta

Rausch

Rylander

2022

Numer Methods Biomed Eng

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“…Therefore, the friction coefficient is expressed as follows: In Figure 5, the different data obtained through experiments are fitted onto a straight line, and the slope of this line describes the measured friction coefficient. The force condition after the insertion may be more complicated than that in this experiment because of the complex mechanical conditions of a biological soft tissue, including elastic plastic strain and fracture [30]. Therefore, in this study, the tiny error marked in Figure 5 was ignored, and the friction coefficient was set as 0.03, which was within the data range given by the coating provider (Chengdu DAXAN Innovative Medical Tech.…”

Section: Measurement Of the Coefficient Of Friction (Cof) Between Thementioning

confidence: 96%

Influence of a Biocompatible Hydrophilic Needle Surface Coating on a Puncture Biopsy Process for Biomedical Applications

et al. 2020

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A puncture biopsy is a widely used, minimally invasive surgery process. During the needle insertion process, the needle body is always in direct contact with a biological soft tissue. Tissue adhesion and different degrees of tissue damage occur frequently. Optimization of the needle surface, and especially the lubrication of the needle surface, can deal with these problems efficiently. Therefore, in this paper, a biocompatible hydrophilic coating was applied onto the surface of a needle to improve the surface quality of the needle surface. Further, a simplified finite element model of insertion was established, and extracorporeal insertion experiments were used to verify the accuracy of the model. Then, by analyzing a simulation model of a coated needle and a conventional needle, the influence of the application of the coated needle on the insertion process was obtained. It can be seen from the results that the coating application relieved the force on the needle and the soft tissue during the insertion process and could significantly reduce friction during the insertion process. At the same time, the deformation of biological soft tissue was reduced, and the adhesion situation between the needle and tissue improved, which optimized the puncture needle.

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“…5,19 Almost all studies focused on the relationship between the insertion force and needle deflection during deep penetration, however, almost, no attempt has been made on the correlation between the peak insertion force and the fracture processes inside the tissues or gels. 7,11,14,15,17,20,21 Recently, we have shown that multiple peaks in the insertion force correspond to axisymmetric, stable, and quasiperiodic cone cracks. 10…”

Section: Introductionmentioning

confidence: 99%

Cone cracks in tissue-mimicking hydrogels during hypodermic needle insertion: the role of water content

2022

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Evaluation of the friction coefficient, the radial stress, and the damage work during needle insertions into agarose gels

Cited by 29 publications

References 36 publications

Convection‐enhanced delivery with controlled catheter movement: A parametric finite element analysis

Convection‐enhanced delivery with controlled catheter movement: A parametric finite element analysis

Influence of a Biocompatible Hydrophilic Needle Surface Coating on a Puncture Biopsy Process for Biomedical Applications

Cone cracks in tissue-mimicking hydrogels during hypodermic needle insertion: the role of water content

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