Evaluation of the Feasibility of Ultrasonic Aerosolization of Therapeutic Substance in Animal Model

CO2-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis

“…Since a homogeneous IP distribution of viscous materials such as hydrogels cannot be obtained with the nozzle currently used in (e)­PIPAC surgeries, a novel nozzle was developed in collaboration with Medspray. In a preclinical setting, other research groups have developed a variety of alternative nozzle designs, based on the same nebulization mechanism as the Capnopen, i.e., high pressure atomization, , and different aerosolization principles, such as jet nebulization, ,− mesh nebulization, − and ultrasonic nebulization, , with the aim to improve the uniformity of the IP aerosol deposition of non-viscous aqueous solutions . The majority of these investigational nozzles aim to produce aerosols with a reduced droplet size because the distribution of smaller aerosol droplets is assumed to be less influenced by gravity.…”