Evaluation of the EtOAc Extract of Lemongrass (Cymbopogon citratus) as a Potential Skincare Cosmetic Material for Acne Vulgaris

Abstract

This study evaluated the biological properties of lemongrass (Cymbopogon citratus) extracts. The EtOAc extract of lemongrass had DPPH, TEAC, and nitric oxide-scavenging activity assay results of 58.06, 44.14, and 41.08% at the concentration of 50, 10, and 50 μg/ml, respectively. The EtOAc extract had higher elastase and collagenase inhibitory activities than the 80% MeOH, n-hexane, BuOH, and water extracts and comparable whitening activity toward monophenolase or diphenolase. Also, the EtOAc fraction had higher lipase inhibitory and antimicrobial activities against Cutibacterium acnes among extracts which is known to an important contributor to the progression of inflammatory acne vulgaris, and an opportunistic pathogen present in human skin. Total phenolic and flavonoid concentrations in the EtOAc extract were 132.31 mg CAE/g extract and 104.50 mg NE/g extract, respectively. Biologically active compounds in lemongrass extracts were analyzed by LC-MS. This study confirms that lemongrass extracts have potential use as cosmetic skincare ingredients. Thus, lemongrass can be considered a promising natural source of readily available, low-cost extracts rich in antioxidant, skincare, and antimicrobial compounds that might be suitable for replacing synthetic compounds in the cosmeceutical industry.

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

“…Its tyrosinase inhibitory activity (whitening properties) instead was comparable to those of the other extracts. The ethyl acetate fraction displayed higher lipase and antimicrobial (C. acnes) activities among extracts in line with its higher content of phenolic acids (cinnamic acid, caffeic acid, salicylic acid, phydroxybenzoic acid, gallic acid, ferulic acid, protocatechuic acid) and flavonoids (isovitexin, luteolin, catechin, tricin, chrysoeriol 7-O-glucoside) (Figure 9) [30]. Rodríguez-López J. et al (2022) highlighted the enormous potential in anti-AV formulations of a biosurfactant extract obtained from corn (Zea mays L.) steep water, a by-product of the milling industry.…”

Phytochemical investigation on the aerial parts of Veratrum versicolor f. viride Nakai and their biological activities

“…Moreover, inhibition of elastase enzyme (porcine pancreas) activity was used to evaluate the antiaging properties of the isolated compounds, and the results are shown in the Table . It was observed that compounds 5 and 8 showed moderate antielastase activity with IC 50 values of 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively, compared to ursolic acid [ 37 ] (IC 50 : 96.88 μM), which was used as the positive control. A melanin content assay was conducted to observe the inhibitory effect of the isolated constituents on melanin production.…”

Bioactivos de la hierba luisa utilizados en la industria

“…Durán et al (2021) recalcan que en la elaboración de perfumes los principios activos potencian su aroma. Incluso, Kim et al (2022) establecen que en los desodorantes al poseer antioxidantes eliminan el olor corporal y tienen la capacidad protectora en la piel. De igual modo Khan (2020) define en su estudio sobre shampoo de hierba luisa que tiene efectos sobre la presencia de caspa en el cuero cabelludo.…”