Evaluation of the Ethnomedical Claims of<i>Murraya koenigii</i>.

Adebajo, AC; Olayiwola, Gbola; Verspohl, J. Eugen; Iwalewa, E. O.; Omisore, N. O.; Bergenthal, Dieter; Kumar, Vijaya; Adesina, S. K.

doi:10.1080/13880200490902518

Cited by 37 publications

(46 citation statements)

References 34 publications

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“…The fresh leaves of Murraya koenigii (MKL) are traditionally added to Indian gravy and other vegetables for the delicious taste they impart to various South Indian dishes. Ayurvedic literature as well as recent studies highlights the potential of MKL as an antidiabetic agent (Yadav et al, 2002;Adebajo et al, 2004Adebajo et al, , 2006Kesari et al, 2005). Leaf extract of Murraya koenigii have also been reported to posses antifungal, antineoplastic, nitric oxide scavenging and antioxidant activities (Das et al, 1965;Khan et al, 1996a;Chakrabarty et al, 1997;Khan et al, 1997;Ramsewak, et al, 1999;Tachibana et al, 2001;Baliga et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Leaf extract of Murraya koenigii have also been reported to posses antifungal, antineoplastic, nitric oxide scavenging and antioxidant activities (Das et al, 1965;Khan et al, 1996a;Chakrabarty et al, 1997;Khan et al, 1997;Ramsewak, et al, 1999;Tachibana et al, 2001;Baliga et al, 2003). Anti-oxidant, Antitumor, Anti-microbial and Anti-diabetic actives have been reported for some carbazole alkaloids, which were identified as the major compounds in Murraya koenigii leaves (Tachibana et al, 2001;Adebajo et al, 2004Adebajo et al, , 2006Ito et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYMurraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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show abstract

“…10 While studies have revealed the anti -diabetic property of MK 11,12,13 inconsistent results on the effect of MK extracts have also been reported. 14,15,16 In the present study, we show reduced hyperglycemia and amelioration of insulin sensitivity induced by fatty acid Palmitate and adipogenic inhibitory action of two different solvent ratio Murraya koenigii leaf extracts, besides preventing from diabetes associated complication.…”

Section: Introductionmentioning

confidence: 81%

Hydroalcoholic and Alkaloidal Extracts of Murraya koenigii(L.) Spreng Augments Glucose Uptake Potential against Insulin Resistance Condition in L6 Myotubes and Inhibits Adipogenesis in 3T3L1 Adipocytes

Parthasarathy¹,

Murthy²,

Girija³

et al. 2018

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Background:Murraya koenigii, commonly known as "curry leaves" is native to India. The highly valued part of the plant is the leaves which possess various biological activities. Objective: The present study aimed to investigate the antidiabetic effect of Murraya koenigii (MK) leaf extracts, of two different solvent ratios. Materials and methods: 70% hydroalcoholic and alkaloidal extracts of MK leaves were prepared by cold maceration method. Preliminary phytochemical analysis was carried out for both the extracts. In vitro anti diabetic activity was screened by inhibitory action on α -amylase, α -glucosidase enzymes. Further, the 70% hydroalcoholic and alkaloidal extracts were assessed for glucose uptake potential, anti -adipogenic property, as well as inhibitory activity on diabetes associated complications. HPTLC quantification of major phytoconstituent was carried out. Results: The study showed presence of various phytoconstituents such as, polyphenols, alkaloids, tannins, reducing sugars etc. The 70% hydroalcoholic and alkaloidal extracts of MK leaves exhibited >90% inhibition against carbohydrate metabolising enzymes compared to aqueous and absolute alcohol extracts. Both the extracts showed enhanced glucose uptake in L6 myotubes attenuating the effect of Palmitate induced insulin resistance. Significant inhibition on adipogenesis was exerted by both 70% hydroalcoholic and alkaloidal extracts of MK leaves. Besides, marked inhibition of advanced glycation end products was exhibited by the extracts. HPTLC quantification analysis of the aforementioned extracts showed the presence of major phytoconstituent, Mahanine, in it. Conclusion: The results of the present study showed that MK possesses significant antidiabetic property and also exhibited considerable effect in preventing diabetes associated complications. The potent antidiabetic activity of MK could be attributed to the presence of Mahanine, the major active constituent, which is a carbazole alkaloid.

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“…[4] It is well known for its ethno pharmacological importance for treating various ailments including free radical induced cancer, various cancer forms, prevention of metastasis, apoptosis, etc. [5] Water, alcohol, hydroalcoholic, petroleum ether, and chloroform extract of M. koenigii L. leaves and stem bark [6] , have demonstrated potent anti-cancer activity owing to the presence of carbazole components. The phytochemical studies have revealed the presence of several carbazole alkaloids like murrayanine [7] , mahanine [8] , mahanimbine, mahanimbicine [9] , murrayacine [10] , koenoline [11] , girinimbine [12] , murryafoline A [13] , mahaimboline, isomahanine [14] , etc.…”

Section: Introductionmentioning

confidence: 99%

Substituted Thiazole Linked Murrayanine-Schiff�s Base Derivatives as Potential Anti-Breast Cancer Candidates: Future EGFR Kinase Inhibitors

Mahapatra¹,

Das²,

Shivhare³

2017

IJPSDR

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Cancer is the second leading causes of mortality across the planet which has had affected millions. In spite of massive efforts in producing new molecules and chemotherapeutic approaches for managing cancer, it continued to be the global threat. Small hybrid molecules have gained popularity in chemotherapy due to their potential and smart characteristics in modulating biological targets. The present research attempts in developing few novel hybridized derivatives of murrayanine (an active carbazole derivative) by the semi-synthetic approach to form substituted thiazole linked murrayanine-Schiff's base derivatives. The protocol involved murrayanine 1 as the template material for constructing a hybridized Schiff's base intermediate 3, which further by Hantzch's cyclization was subsequently converted to various hybridized thiazoles analogs 5a-5f. The purity of the synthesized compounds was ascertained by sophisticated analytical techniques. The anti-cancer potential was screened against breast cancer cell lines; MCF-7 and MDA-MB-231 by Sulforhodamine B (SRB) assay. The compound 5b displayed most potent anti-proliferative activity with IC50 values of 23.41μM against MCF-7 cell line and 32.15μM against MDA-MB-231 cell line. It has been observed that analogs having electron withdrawing substituents exhibited pronounced anticancer activity. The docking study was performed by Autodock Vina where the results were found to be in full agreement with the cytotoxic study, depicting that the probable cytotoxic outcome by EGFR inhibitory mechanism. The study revealed the potential of novel hybridized derivatives as active anti-breast cancer candidates. The research will encourage (medicinal) chemists in rationally designing of semi-synthetic analogs of a heterocyclic prototype having pronounced anti-cancer activity. Keywords

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Evaluation of the Ethnomedical Claims ofMurraya koenigii.

Cited by 37 publications

References 34 publications

Nootropic Potential of Murraya koenigii leaves in Rats

Nootropic Potential of Murraya koenigii leaves in Rats

Hydroalcoholic and Alkaloidal Extracts of Murraya koenigii(L.) Spreng Augments Glucose Uptake Potential against Insulin Resistance Condition in L6 Myotubes and Inhibits Adipogenesis in 3T3L1 Adipocytes

Substituted Thiazole Linked Murrayanine-Schiff�s Base Derivatives as Potential Anti-Breast Cancer Candidates: Future EGFR Kinase Inhibitors

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