Evaluation of the epidemiological significance of molecular genetic factors in relation to the intensity of post-vaccination immunity against hepatitis B

Власенко, Н. В.; Чурилова, Н. С.; Loskutova, T. A.; Миронов, К. О.; Esman, A. S.; Dunaeva, E. A.; Semenenko, Т. A.; Rodionova, Z. S.; Никитин, И. Г.; Tutelyan, A.V.; Кузин, С. Н.; Акимкин, В. Г.

doi:10.36233/0372-9311-246

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Nevertheless, children who have received the hepatitis B vaccine experience a decline in the levels of anti-HBs due to several factors. It has been shown in different clinical studies that these factors include time after vaccination, gender, obesity, immunosuppression and variants of genotypes (18)(19)(20)(21)(22). In addition, it is suggested that the varying rates of anti-HBs positivity in clinical studies may be due to the age range of the patient group studied, socioeconomic differences in the study area and different vaccination protocols (23).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Hepatitis B seroprevalence and AntiHbs Levels in Children Consulted for Dental Procedures Under Anaesthesia

Sert,

Kaya

2024

Genel Tıp Dergisi

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Background/Aims: Hepatitis B virus infection continues to be a major global and national public health concern. The aim of this study was to examine the seroprevalence of hepatitis B virus in children who were consulted to child health and diseases before dental intervention and to share our findings with the healthcare personnel involved on this subject. Methods: A total of 932 children were enrolled in the study, of which 533 (57.2%) were boys and 399 (42.8%) were girls. In the blood samples taken; hepatitis B virus tests were studied with the Enzyme Linked Immuno Sorbent Assay method. The results of blood samples and demographic data of the patients were evaluated. Results: HBsAg positivity was not found in any of the patients (0%). AntiHbs seropositivity was found in 73.8% of the whole patient population. No statistically significant difference was detected when comparing the anti-HBs levels based on gender. The average age of children with antiHbs seropositive was found to be statistically significant lower than that of those with antiHBs negative. The median anti-HBS antibody levels were significantly higher in the group of children under 5 years old than in the other two age groups older than five years old in our study. When investigating the association between the level of antiHBs and age, a weak negative correlation was found. Conclusions: Our study showed that the antiHbs seropositivity is higher in Konya compared to previous studies. It suggests that the national vaccination program has a positive impact on antiHbs seroprevalence. Our study revealed that children under the age of five displayed the highest levels of anti-HBs seropositivity, while the anti-HBs levels diminished with advancing age.

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Section: Discussionmentioning

confidence: 99%

Preoperative Hepatitis B seroprevalence and AntiHbs Levels in Children Consulted for Dental Procedures Under Anaesthesia

Sert,

Kaya

2024

Genel Tıp Dergisi

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“…Продолжительность напряженного иммуните та зависит от возраста людей в начале вакцина ции. Согласно ранее проведенным исследованиям, наиболее высокие показатели напряженности иммунитета констатированы у людей, вакциниро ванных в возрасте до 30 лет [22,26]. В нашей рабо те показано, что уровень antiHBs более 100 мМЕ/ мл и 400 мМЕ/мл в основном обнаруживается у людей более молодого возраста, и в дальнейшем с увеличением возраста уровень антител снижает ся.…”

Section: рисунок 2 распределение уровня напряженности поствакцинально...unclassified

Evaluation of the Intensity of Post-Vaccination Immunity to Hepatitis B among HIV-infected and Conditionally Healthy Persons in Western Siberia

Kartashov,

Svirin,

Krivosheina

et al. 2024

Epidemiology and Vaccinal Prevention

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Relevance. Hepatitis B often causes liver cirrhosis and hepatocellular carcinoma, especially among patients with HIV. Vaccination is the main prophylaxis of HBV for preventing infection and developing chronic disease. Studying the duration of postvaccination immunity and the expediency of revaccination in different age and risk groups is important for improving the strategy of immunoprophylaxis of B hepatitis.Aims. Study was to determine the level of post-vaccination immunity to HBV and specific antibodies (anti-HBc and anti-HBs) among HIV-positive patients and the healthy population of Novosibirsk and Tomsk.Materials and methods. 536 blood samples were taken from HIV-positive patients and 337 blood samples from healthy people (pregnant women and persons undergoing a routine medical examination). The presence of HBsAg, anti-HBs IgG, and anti-HBcIgG were determined in the samples.Results. The proportion of post-vaccination immunity decreased in older age groups with an increase in the proportion of post-exposure immunity. The proportion of HIV-positive patients who had contact with HBV was higher than among healthy people. Around 70% of people in each group had a low level of protective antibodies anti-HBs (lower than 100 IU). A high level of anti-HBs (higher than 400 IU) was determined in 10% of examined people. The proportion of low levels of anti-HBs increased with age, while average and high levels of post-vaccination immunity were less common with increasing age.Conclusion. A low proportion of HIV-positive people, who have been effectively vaccinated against hepatitis B, was noticed. Annual blood tests for the presence of HBsAg, anti-HBs, and anti-HBc, in combination with determining DNA HBV, can be recommended for HIV-positive patients who have a risk of developing an occult form of hepatitis B.

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Distribution of human gene polymorphisms allele frequencies associated with viral infections

Vlasenko,

Chanyshev,

Dubodelov

et al. 2023

Problems of Virology

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Introduction. The design of studies aimed at finding the association between the genetic factor and the studied feature (disease) involves a comparison of the ratio of genotypes or allelic proportions in the study group with those in the control group. At the stage of determining the ratio of genotypes of the studied polymorphisms in the reference group, researchers meet a number of problems, which are the subject of the present work. Aim of the work is to provide scientific rationale for the feasibility of creating a national information system comprising genetic data of the relatively healthy population of Russia, incorporating its ethnic diversity. Materials and methods. The study group, total 1020 people, was genotyped for a number of single nucleotide polymorphisms of human genes. A comparative characteristic of the frequency distribution of the studied polymorphisms with those presented in international databases as reference data was carried out using χ2 index. Results. The frequency of SNP rs4986790 of the TLR4 gene significantly differs from the EUR population (p = 0.032) and the CEU subpopulation (p = 0.047). The allele frequencies of the rs1800795 (IL6) and rs1800896 (IL10) polymorphisms in the study population differ from the CEU subgroup (p = 0.030 and 0.012, respectively). The frequency of SNP rs2295119 (HLA-DPA2) in the study group is significantly different from the EUR population (p = 0.034). Conclusion. The analysis carried out in this work confirms the need to create a domestic information system containing data on the occurrence of SNP alleles and genotypes for a conditionally healthy population and in subgroups with various pathological conditions.

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Evaluation of the epidemiological significance of molecular genetic factors in relation to the intensity of post-vaccination immunity against hepatitis B

Cited by 3 publications

References 28 publications

Preoperative Hepatitis B seroprevalence and AntiHbs Levels in Children Consulted for Dental Procedures Under Anaesthesia

Preoperative Hepatitis B seroprevalence and AntiHbs Levels in Children Consulted for Dental Procedures Under Anaesthesia

Evaluation of the Intensity of Post-Vaccination Immunity to Hepatitis B among HIV-infected and Conditionally Healthy Persons in Western Siberia

Distribution of human gene polymorphisms allele frequencies associated with viral infections

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