Evaluation of the efficacy of drug treatment based on measurement of the oxidative stress, using reactive oxygen metabolites and biological antioxidant potential, in children with autism spectrum disorder and attention deficit hyperactivity disorder

Kitaoka, Taisuke; Morimoto, Masahito; Hashimoto, Toshiaki; Tsuda, Yoshimi; Nakatsu, Tadanori; Kyotani, Shojiro

doi:10.1186/s40780-020-00164-w

Cited by 12 publications

(8 citation statements)

References 23 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The analysis of comparison between the genders revealed the d-ROMs was significantly higher in women. This result agrees with other studies carried out in healthy individuals (47) and individuals with various pathologies (35,43,46,49,59,66). One of the possible explanations for this result is the hormonal changes in women associated with blood concentrations of estrogen and, therefore, on menopausal status (46).…”

Section: Discussionsupporting

confidence: 93%

Characterization of the redox status of cancer patients through the d-ROMs and BAP test and correlation of these parameters with blood variables

Oliveira¹,

Iorio²,

Paraíso³

et al. 2023

Preprint

View full text Add to dashboard Cite

Oxidative distress and inflammation are common biochemical disorders in individuals with cancer. The measurement of oxidative stress in oncology can be useful in clinical practice to monitor the effectiveness of therapy and unwanted effects of the treatment. Thus, the aim of the present study was to evaluate the redox status through the reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests and investigate the correlations of these parameters with blood variables in cancer patients. This is an observational, retrospective study of analysis of medical records of patients evaluated the period from 2018 to 2020 in an integrative medicine center. The inclusion criteria were individuals of both sexes, over 18 years of age, diagnosed with cancer who performed the d-ROMs and BAP test in the same period of blood analysis. Following the inclusion criteria, the final sample of the study were 57 individuals, 60% were woman and 40% were men. The evaluation of redox state showed that the d-ROMs were high (420.2 ± 112.1 U CARR) in total sample and higher in women compared to male (p < 0.01) and BAP tests were normal (2332 ± 812 μmol/l). The oxidative parameters, d-ROMs and OSI, was correlated positively with BAP, red cell distribution width (only d-ROMs), platelets (Plt), C-reactive protein (CRP), erythrocyte sedimentation (ESR) and negatively with hemoglobin (Hb) and mean corpuscular hemoglobin (MCH). Regarding the antioxidant potential index, BAP/dROMs, were correlated positively with Hb and serum albumin (HAS) and negatively correlated with Plt, CRP and ESR. The study shows that redox status of an individual with cancer is altered, and it is possible to monitor this system in clinical practice through d-ROMs and BAP test. These parameters, in addition to being suitable for assessing oxidative stress, were correlated with parameters predictors of inflammation.

show abstract

Section: Discussionsupporting

confidence: 93%

Characterization of the redox status of cancer patients through the d-ROMs and BAP test and correlation of these parameters with blood variables

Oliveira¹,

Iorio²,

Paraíso³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Finally, the levels of MDA and free sulphydryl groups in the spleen were higher in 5-week-old SHR than in control rats [ 66 ]. Recently, evaluation of serum levels of hydroperoxide, an oxidative stress marker, was shown to be higher in preschool children with ADHD [ 67 ].…”

Section: Role Of Oxidative Stressmentioning

confidence: 99%

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Corona

2020

Antioxidants

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder of childhood. Although abnormalities in several brain regions and disturbances of the catecholaminergic pathway have been demonstrated, the pathophysiology of ADHD is not completely understood, but as a multifactorial disorder, has been associated with an increase in oxidative stress and neuroinflammation. This review presents an overview of factors that increase oxidative stress and neuroinflammation. The imbalance between oxidants and antioxidants and also the treatment with medications are two factors that can increase oxidative damage, whereas the comorbidity between ADHD and inflammatory disorders, altered immune response, genetic and environmental associations, and polymorphisms in inflammatory-related genes can increase neuroinflammation. Evidence of an association with these factors has become valuable for research on ADHD. Such evidence opens up new intervention routes for the use of natural products as antioxidants that could have potential as a treatment against oxidative stress and neuroinflammation in ADHD.

show abstract

“…The exclusion criteria were: (1) categorized as having GD according to the IGD-20 Test, (2) having an intellectual disability, (3) having a psychiatric disorder, and (4) those refusing to provide informed consent. Diagnosis was based on the criteria for ASD as defined in the DSM-5; Autism Diagnostic Observation Schedule, Second Edition (ADOS-2); and Parent-Interview ASD Rating Scale-Text Revision (PARS-TR) [ 25 ]. The study period was from April 2020 to August 2020.…”

Section: Methodsmentioning

confidence: 99%

Influence of an Esports Program on Problematic Gaming in Children with Autistic Spectrum Disorder: A Pilot Study

Kawabe

Horiuchi

Hosokawa

et al. 2022

Behavioral Sciences

View full text Add to dashboard Cite

Esports (electronic sports) programs are a variant of competitive gaming and have expanded worldwide in recent years. The prevalence of problematic gaming and gaming disorders (GD) is predicted to increase in adolescents. Children with autism spectrum disorder (ASD) have a high rate of digital gaming use, and their characteristics, such as social communication deficits and restricted interests, might contribute to problematic gaming. In this study, we aimed to examine whether participation in an Esports program would lead to problematic gaming or GD in children with ASD. The Internet Gaming Disorder Test (IGD-20) scores, Kid-KINDL scores, and gaming time at home were assessed in eight children with ASD before beginning the Esports program and at the three-month follow-up timepoint. The program was held once a week at the welfare service center, where the participants played a set game for 60 min. The results indicated there was no significant worsening in any of the scores after the program. Our program provided the participation time and frequency of Esports, type of game, and motivation of the participants are adequately considered. Even though this pilot study is limited by the small sample size, we concluded that the risk of these activities leading to problematic gaming might be low.

show abstract

Evaluation of the efficacy of drug treatment based on measurement of the oxidative stress, using reactive oxygen metabolites and biological antioxidant potential, in children with autism spectrum disorder and attention deficit hyperactivity disorder

Cited by 12 publications

References 23 publications

Characterization of the redox status of cancer patients through the d-ROMs and BAP test and correlation of these parameters with blood variables

Characterization of the redox status of cancer patients through the d-ROMs and BAP test and correlation of these parameters with blood variables

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Influence of an Esports Program on Problematic Gaming in Children with Autistic Spectrum Disorder: A Pilot Study

Contact Info

Product

Resources

About