Evaluation of the Efficacy of Chlorhexidine-Based Medications in Patients With Chronic Generalized Periodontitis

Abstract

The treatment of periodontal diseases remains a relevant issue today, as there is a wide range of therapeutic agents available for this pathology. Local therapeutic agents are commonly used in the oral cavity. Chlorhexidine is considered the gold standard in periodontology. The aim of this study was to evaluate the efficacy of chlorhexidine-based medications in patients with chronic generalized periodontitis: Dentaid PerioAid Gel and Perio-Aid Protect. The study included 40 patients, with 20 diagnosed with chronic generalized periodontitis stage I-II and the other 20 with chronic generalized periodontitis stage II-III. All patients were further divided into 4 subgroups, with 10 patients in each subgroup.
 After 2 months of clinical research and patient examination, the following data were obtained for subgroup A1: the average plaque index (PI) was 31.82±0.96%, and the average bleeding on probing (BOP) was 18.67±2.47%. Among the patients in subgroup A1, the average depth of gingival sulcus was 96.41±0.76% for depths of 1-3 mm and 3.59±0.76% for periodontal pockets with depths of 4-5 mm.
 The measurements for subgroup A2 after 2 months of clinical research were as follows: the average PI was 32.16±1.10%, and the average BOP was 14.70±0.79%. Among the patients in subgroup A2, the average depth of gingival sulcus was 97.14±0.69% for depths of 1-3 mm and 2.74±0.68% for periodontal pockets with depths of 4-5 mm.
 The measurements for subgroup B1 after 2 months of clinical research were as follows: the average PI was 46.44±2.65, and the average BOP was 28.79±3.66%. Among the patients in subgroup B1, the average depth of gingival sulcus was 81.19±7.90% for depths of 1-3 mm, 14.06±5.50% for periodontal pockets with depths of 4-5 mm, and 4.55±3.13% for pockets with depths ≥ 6 mm.
 The measurements for subgroup B2 after 2 months of clinical research were as follows: the average PI was 44.09±1.00%, and the average BOP was 25.97±2.28%. Among the patients in subgroup B2, the average depth of gingival sulcus was 81.61±4.83% for depths of 1-3 mm, 15.96±4.90% for periodontal pockets with depths of 4-5 mm, and 1.18±0.52% for pockets with depths ≥ 6 mm.
 Comparing the obtained results of the clinical study in patients with chronic generalized periodontitis, it can be concluded that the treatment of this pathology with local application of chlorhexidine-based agents contributed to the improvement of clinical parameters after 2 months compared to the initial situation.