Evaluation of the efficacy of an appeasing pheromone diffuser product vs placebo for management of feline aggression in multi-cat households: a pilot study

DePorter, Theresa; Bledsoe, David; Beck, Alexandra; Ollivier, Elodie

doi:10.1177/1098612x18774437

Cited by 35 publications

(28 citation statements)

References 21 publications

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“…19 For cats that are showing agonistic interactions, whether covert or overt, a synthetic analogue of feline appeasing pheromone -Feliway MultiCat (USA) or Feliway Friends (Europe) (Ceva) -may diminish reactivity and promote calmer behaviors. 20 See article in Part 2 on pheromone therapy for further information.…”

Section: Pheromone Therapymentioning

confidence: 99%

Common feline problem behaviors: Urine spraying

Horwitz

2019

Journal of Feline Medicine and Surgery

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Practical relevance: Urine spraying (synonymous terms include urine marking or scent marking) is commonly described as urine deposited on vertical surfaces while the cat is in a standing position. With the increasing trend of keeping cats indoors in some countries and the potential resultant increase in frustration-related behaviors, urine spraying may occur in the home. Although also a normal feline behavior, it is usually not deemed acceptable when the cat targets household possessions. Urine spraying is a common behavioral complaint that practitioners receive from cat owners and has the potential to disrupt the human–cat bond. In fact, feline elimination issues are a frequent reason cited by owners when they relinquish their cats to shelters and rescue organizations. Clinical challenges: While the location of the deposited urine should be diagnostic, this is not always the case. Urine marking can occur on horizontal surfaces, thus complicating the diagnosis. Urine spraying by intact males and females is used to signal availability for mating but the behaviour can also be exhibited by neutered animals. Multiple factors including medical problems can trigger the onset and maintenance of urine spraying, and correct identification of these is necessary for treatment to be most successful. Evidence base: This review draws on information from multiple studies that have been published on the normal aspects of urine spraying in cats, the frequency as reported by owners, the relationship of urine spraying to intercat aggression and various treatment options including behavior modification, pheromone therapy and use of psychoactive medication.

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Section: Pheromone Therapymentioning

confidence: 99%

Common feline problem behaviors: Urine spraying

Horwitz

2019

Journal of Feline Medicine and Surgery

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“…On the basis of ligand-binding experiments, using the displacement of a fluorescent probe, and in silico docking simulations, we have shown that a recombinant form of Fel d 1 binds with good affinities some fatty acids and steroids, the best ligands being lauric acid and androstenone (Kd = 2.6 and 2.4 µ M, respectively). Lauric acid is a component of the mixture of fatty acids described as the cat appeasing pheromone having effects on cats' social interactions [36,37], together with oleic, linoleic, and myristic acids, which also showed some affinity to rFel d 1. Androstenone is a volatile steroid pheromone found in high concentrations in the saliva of male pigs and triggers attraction/standing responses in estrous females [43].…”

Section: Discussionmentioning

confidence: 99%

“…The feline facial pheromone F3 has been shown to promote calmness and reduce stress with its related undesirable consequences in cats, such as urine spraying and marking behavior [32][33][34][35]. The maternal cat appeasing pheromone has been shown to have appeasing effects and to facilitate social interactions in cats [36,37]. We have also tested some steroids since several secretoglobins have been experimentally shown to bind steroid hormones, including pig pheromaxein, rabbit uteroglobin, mouse salivary ABP, and rat prostatein [19,[38][39][40].…”

Section: Introductionmentioning

confidence: 99%

The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study

Bienboire-Frosini

Rajesh

Pelosi

et al. 2020

IJMS

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The major cat allergen Fel d 1 is a tetrameric glycoprotein of the secretoglobin superfamily. Structural aspects and allergenic properties of this protein have been investigated, but its physiological function remains unclear. Fel d 1 is assumed to bind lipids and steroids like the mouse androgen-binding protein, which is involved in chemical communication, either as a semiochemical carrier or a semiochemical itself. This study focused on the binding activity of a recombinant model of Fel d 1 (rFel d 1) towards semiochemical analogs, i.e., fatty acids and steroids, using both in silico calculations and fluorescence measurements. In silico analyses were first adopted to model the interactions of potential ligands, which were then tested in binding assays using the fluorescent reporter N-phenyl-1-naphthylamine. Good ligands were fatty acids, such as the lauric, oleic, linoleic, and myristic fatty acids, as well as steroids like androstenone, pregnenolone, and progesterone, that were predicted by in silico molecular models to bind into the central and surface cavities of rFel d 1, respectively. The lowest dissociation constants were shown by lauric acid (2.6 µM) and androstenone (2.4 µM). The specific affinity of rFel d 1 to semiochemicals supports a function of the protein in cat’s chemical communication, and highlights a putative role of secretoglobins in protein semiochemistry.

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“…A utilização de análogos sintéticos pode ser feita para situações estressantes ou como parte de terapia comportamental, podendo ser 'spray' ou difusor (ATKINSON, 2018c). O uso de feromônios sintéticos em lares com muitos gatos pode reduzir conflitos e aumentar a sensação de bemestar dos animais (DEPORTER et al, 2018).…”

Section: Tabela 3 Acertos E Erros Na Categoria "Ambienteunclassified