Evaluation of the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis

Филатова, Е. С.; Turovskaya, E.; Алексеева, Л. И.

doi:10.17116/terarkh2017891281-85

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, this combination produced a notably better clinical outcome in fibromyalgia when compared to monotherapy (Gilron et al, 2016). There is little data regarding the use of gabapentinoids in pain with a pure inflammatory component, although a recent study indicated that the combination of pregabalin with a NSAID in knee osteoarthritis patients with neuropathic pain was more effective than monotherapy with the NSAID alone (Filatova et al, 2017).…”

Section: Clinical Approachmentioning

confidence: 99%

Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain

et al. 2019

View full text Add to dashboard Cite

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral and central monoaminergic dysfunction has been demonstrated in certain types of pain, particularly in neuropathic pain. Accordingly, drugs that modulate the monaminergic system and that were originally designed to treat depression are now considered to be first line treatments for certain types of neuropathic pain (e.g., serotonin and noradrenaline (and also dopamine) reuptake inhibitors). The analgesia induced by these drugs seems to be mediated by inhibiting the reuptake of these monoamines, thereby reinforcing the descending inhibitory pain pathways. Hence, it is of particular interest to study the monoaminergic mechanisms involved in the development and maintenance of chronic pain. Other analgesic drugs may also be used in combination with monoamines to facilitate descending pain inhibition (e.g., gabapentinoids and opioids) and such combinations are often also used to alleviate certain types of chronic pain. By contrast, while NSAIDs are thought to influence the monoaminergic system, they just produce consistent analgesia in inflammatory pain. Thus, in this review we will provide preclinical and clinical evidence of the role of monoamines in the modulation of chronic pain, reviewing how this system is implicated in the analgesic mechanism of action of antidepressants, gabapentinoids, atypical opioids, NSAIDs and histaminergic drugs.

show abstract

Section: Clinical Approachmentioning

confidence: 99%

Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain

et al. 2019

View full text Add to dashboard Cite

show abstract

Personalized character of toxic effects through mass nonlethal poisoning by phenazepam and other psychoactive substances

Akimova,

Barsegyan,

Pleteneva

2024

Sud.-med. ekspert.

View full text Add to dashboard Cite

Prevalence of аcute articular syndrome. Literature review and own data

et al. 2022

View full text Add to dashboard Cite

The study of the occurrence of articular syndrome in general, and acute articular syndrome (AAS) in particular, is an important medical and social task, the solution of which makes it possible to determine the amount of necessary forces and means for the organization of medical care for these patients. Since 2008, the authors have been studying the features of diagnosis and treatment of patients with AAS, for the first time in the Russian Federation on the basis of the St. Petersburg Research Institute of Emergency Medicine named after I. I. Dzhanelidze introduced the concept of providing medical care to patients with AAS into clinical practice. The study of data on the prevalence of articular syndrome allows us to outline ways to optimize diagnostic and therapeutic algorithms, reducing the time of diagnosis of diseases and optimizing the duration of the inpatient stage of treatment.

show abstract

Evaluation of the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis

Abstract: Combination therapy using pregabalin in KOA patients having the signs of NP is more effective than monotherapy with nonsteroidal anti-inflammatory drugs (aceclofenac).

Cited by 3 publications

References 13 publications

Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain

Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain

Personalized character of toxic effects through mass nonlethal poisoning by phenazepam and other psychoactive substances

Prevalence of аcute articular syndrome. Literature review and own data

Contact Info

Product

Resources

About