Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A

Abstract

The goal of the study was testing the effects of chlorogenic acid ( CA ) supplementation on small intestine healthiness, growth performance, oxidative stress, inflammatory response, and blood biochemical indices in specific-pathogen-free (SPF) chickens after infection with Clostridium perfringens (CP) type A. In this study, 324 1-day-old male SPF chickens were randomly distributed into 6 groups: control group; CA group; CP infection group; CA + CP group; antibiotic group; antibiotic + CP group. All 1-day-old chickens were fed with CA or antibiotic in corresponding treatment group for 13 d. On the 14 d, the chickens in corresponding infection group were challenged with CP type A for 3 d. Samples in each group were collected when the chickens were 17 and 21 d old. This study proves for the first time that CA, a Chinese herbal medicine, can effectively improve growth performance, inhibit small intestine structural damage, improve antioxidant capacity, inhibit damage to ileal mucosal layer construction and tight junctions, inhibit inflammatory cytokines, and ameliorate blood biochemical indices. Therefore, this study provides data for CA being able to effectively alleviate small intestine damage caused by CP type A infection in chickens.

Dietary ellagic acid ameliorated Clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota

“…Previous studies [ 26 , 42 ] reported that C. perfringens challenge reduced body weight gain and feed intake, while heighten FCR of broilers, which were similar to our results. The supplementation of plant extracts, including tannin and polyphenol compounds, have been proved to be effective against NE [ 46 , 66 ], but the effect of EA on the growth performance of broilers has not been reported. In this study, the addition of EA in diet increased ADG and decreased FCR of broilers.…”

The Effect of the Antimicrobial Peptide Plectasin on the Growth Performance, Intestinal Health, and Immune Function of Yellow-Feathered Chickens

“…The small intestine is an important place for digestion and absorption of the animal body, so the morphological structure of the small intestine is often used as an indicator to measure the digestion and absorption functions of an animal. The length of the villi and the depth of crypts reflect the effective area and function of intestinal digestion and absorption of nutrients, and their ratio comprehensively reflects the functional status of the small intestine ( 49 ): the larger the ratio, the larger the contact area of the intestinal mucosa with nutrients and the stronger digestion and absorption functions. In this study, we showed that dietary antimicrobial peptide plectasin (200 mg plectasin/kg of diet) could increase the ratio between the villus length and crypt depth of the ileum, jejunum, and duodenum.…”

Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens

“…We began to feed baicalin to the corresponding groups at the age of 1 day. The composition and nutritional level of basal feeding were shown in Table 2 [ 21 ]. The chickens in the H9N2 AIV infection group and H9N2 AIV infection plus feeding baicalin group were infected with H9N2 AIV at the age of 9 days, and the infection dose was 3-fold 10 6 EID 50 /0.1 mL.…”