Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial

Abstract

Background: Halitosis of oral origin is very common in the general population. Due to their antimicrobial properties, chlorhexidine-based products are widely used in the management of this condition, but these are associated with reversible side effects. In this study we evaluated the efficacy of Lacer HaliTM mouthrinse and toothpaste in subjects with intraoral halitosis after several applications under normal conditions of use. Methods: In this randomized clinical trial with mouth rinse and toothpaste, single-center, double-blinded, parallel participants were assigned to an experimental group (Lacer HaliTM,, n = 20), a positive control group (HalitaTM, n = 20), and a placebo group (n = 20). The active duration of the study was 18 days. The clinical follow-up evaluations were performed at five time points (T0, T1, T2, T3, and T4). The intensity of halitosis was evaluated by organoleptic measurement and the portable gas chromatograph OralChromaTM. The data were analyzed using generalized mixed linear models. Results: Sixty patients completed the study. Lacer HaliTM, in comparison with HalitaTM, did not show statistically significant differences at any time during the study except for the levels of hydrogen sulfide and total volatile sulfur compounds at 15 days, where HalitaTM was better. Compared to the placebo treatment, Lacer HaliTM, was significantly more efficient, in terms of both the organoleptic evaluations at 8 days and the levels of hydrogen sulfide. Conclusions: Lacer HaliTM is an alternative to chlorhexidine-based toothpaste and mouthwashes in the management of halitosis.

Stability of Oral and Fecal Microbiome at Room Temperature: Impact on Diversity

“…Previous studies used Scope® oral wash to preserve oral microbiome samples (Vogtmann et al ., 2019; Yano et al ., 2020), and its stability at room temperature was already verified (Vogtmann et al ., 2019; Wu et al ., 2021); however, it is not easily found in Europe. As chlorhexidine has been commonly used in many clinical trials where effective results have been proven in reducing the proliferation of bacterial species (Eick et al ., 2011; James et al ., 2017; Ben-Knaz Wakshlak, Pedahzur and Avnir, 2019; Brookes et al ., 2020; Sedghi et al ., 2021; Xiang, Rojo and Prados-Frutos, 2021), we opted for Lacer® Chlorhexidine oral wash to preserve the samples. To the best of our knowledge, the stability of Lacer® oral wash samples at room temperature has not been previously studied.…”

“…However, as this solution is not easily found in Europe, Chlorhexidine oral wash (Lacer®) was used. Chlorhexidine has been commonly used in many clinical trials where effective results have been proven in reducing the proliferation of bacterial species (Eick et al ., 2011; James et al ., 2017; Ben-Knaz Wakshlak, Pedahzur and Avnir, 2019; Brookes et al ., 2020; Sedghi et al ., 2021; Xiang, Rojo and Prados-Frutos, 2021). Furthermore, the effect of daily use of chlorhexidine oral wash on the oral microbiome has been studied, showing significant differences in the abundance of some phyla (Bescos et al ., 2020) and a decrease in terms of alpha diversity compared with sputum samples (Chatzigiannidou et al ., 2020; Pragman et al ., 2020).…”

Managing halitosis during the SARS-CoV-2 pandemic

“… 9 It was also reported that Lacer Hali TM could be used as an alternative to chlorhexidine based toothpaste and mouthwashes for the management of halitosis. 10 …”