Evaluation of the Efficacy and Safety of the Ophthalmic Insert Mydriasert in Patients Undergoing Retinal Angiography

Abstract

Mydriasert assures an adequate degree of mydriasis for retinal angiography in both diabetic and nondiabetic patients. There are no differences in efficacy or safety between the insert and the usually administered eyedrops, but the low total drug dose administered with the insert reduces the risk of cardiovascular side effects.

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

“…14,18 Dilation was more stable with the mydriatic ophthalmic insert; at 90 minutes, the pupil diameter was larger in the insert group than in the eyedrops group. 73,74 Other Outcomes The mean number of nurse interventions to reach effective dilation was consistently lower in mydriatic ophthalmic insert groups than in mydriatic eyedrops groups. 6,18 The mean operative time was short and comparable in both groups.…”

“…14 There were no concerns for or significant between-group differences in blood pressure and heart rate. 18,[70][71][72][73] Only 1 study found an increased incidence of high systolic Figure 1. Comparative studies of mydriatic ophthalmic insert and mydriatic eyedrops (* Z first author; AE Z adverse effect; BP Z blood pressure; CNVA Z corrected near visual acuity; DBP Z diastolic blood pressure; HR Z heart rate; ICM Z intracameral mydriatics; MED Z mydriatic eyedrops; MOI Z mydriatic ophthalmic insert; NS Z not significant; Phenyl Z phenylephrine; SBP Z systolic blood pressure; SPK Z superficial punctate keratitis; Tropic Z tropicamide).…”

“…Achieved mydriasis was stable during the entire cataract surgery procedure in both groups. 5,18,[70][71][72][73] The onset was faster with mydriatic eyedrops than with the mydriatic ophthalmic insert, particularly in diabetic subgroups, 73 occurring after approximately 30 to 40 minutes and 40 to 50 minutes, respectively. 14,18 Dilation was more stable with the mydriatic ophthalmic insert; at 90 minutes, the pupil diameter was larger in the insert group than in the eyedrops group.…”

Topical drug delivery devices: A review

“…However, when compared to topical mydriatic eye drops, there was no significant difference in pupil dilatation. In addition, topical mydriatic eye drops dilate the pupil faster (within 15 min) compared to the Mydriasert ® insert (Cagini et al, 2014;Torron et al, 2013). The economic benefits of Mydriasert ® were investigated in a cohort of 1763 patients in the U.K.…”

In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics

“…The second strategy is based on the administration of a solid insert of phenylephrine and tropicamide (Mydriasert ® ) [9]. The insert is an osmotic tablet, placed in the lower conjunctival bag by a trained medical staff and must remain for 30 to 45 min to induce a sufficient mydriasis, causing some discomfort for the patient [10].…”