Evaluation of the efficacy and safety of 308-nm monochromatic excimer lamp in the treatment of resistant alopecia areata

Abstract

Context:Treatment of resistant alopecia areata (AA) can be very challenging and include many options with variable efficacy and safety profiles. The 308-nm excimer lamp has been claimed to offer an effective alternative without significant risks, though there exists a lack of guidelines in this setting.Aims:This study aimed to evaluate the efficacy and safety of the 308-nm excimer lamp in treating resistant AA in Iraqi patients.Settings and Design:A prospective interventional study.Subjects and Methods:Eighteen patients with multiple AA were enrolled in this study. All patients were treated with a 308-nm monochromatic excimer lamp, in two sessions per week for 12 weeks. The efficacy of this modality was evaluated using two methods, namely the Severity of Alopecia Tool (SALT) score and digital photographs which were taken at four points (baseline, 4 weeks, 8 weeks, and 12 weeks). The safety of the equipment was evaluated by the objective recording of adverse reactions and patient satisfaction. Follow-up continued for 6 months after treatment to assess the level of recurrence.Statistical Analysis Used:SPSS software version 23.Results:There was a statistically significant decrease in the SALT score from the baseline (range 11–30; mean 20.33 ± standard deviation [SD] 4.78) to 12 weeks (range 2–24; mean 9.11 ± SD 5.41) (P < 0.001). The overall response rate was 100%, and successful (>50%) regrowth of hair was seen in 55.5% of patients (n = 10). Younger patients responded to the treatment more than the older age group (P < 0.05). No significant side effects were recorded.Conclusions:The results suggest that 308-nm excimer light has a significant effect on resistant cases of multiple AA, with considerable safety and tolerability.

Combining 308-monochromatic excimer phototherapy with monthly IM triamcinolone acetonide for the treatment of resistant alopecia totalis

“…Excimer phototherapy has been used successfully for treating multiple AA and a few cases of AT, for its high-dose monochromatic UV radiation that can trigger apoptosis and induce immunological suppression [11,12,13] . The present study relied on combining intramuscular triamcinolone acetonide with excimer phototherapy to obtain a greater synergistic effect.…”

Overview of the Role of 308 Monochromatic Excimer Phototherapy for the Treatment of Alopecia Areata

“…Follow-up continued for 6 months after treatment to assess the level of recurrence. The results significantly affected resistant cases of multiple AA with considerable safety and tolerability (Figure 1) [17].…”

“…In 2001, Baltas et al reported using the excimer laser to treat vitiligo [11]. Several studies have investigated the efficacy of 308 excimer on various dermatological disorders such as atopic eczema, mycoses fungoides, and AA [12][13][14][15][16][17]. All AA (single, multiple, and totalis) were identified and treated in those studies.…”

“…The poor response was evaluated when the SALT equaled zero. The overall response rate was the percentage of patients who responded positively to the treatment [17].…”

Fractional laser and low-level light combination therapy in patients with recalcitrant alopecia areata

“…Recent research has examined whether low-level light therapy (LLLT) and fractional laser treatments, with or without the addition of topical agents, represent safe and effective alternative treatment options. [10][11][12][13][14][15][16] Since then, several studies have been published on AA treatment using fractional lasers. [17][18][19][20][21][22][23][24][25] In this study, we detail our experience in treating patients with recalcitrant AA using fractional laser and LLLT combination therapy and discuss the treatment outcomes.…”