Evaluation of the effi ciency of the activity of the register of potential donors of hematopoietic stem cells

Abstract

Introduction. One of the problems in providing Russian transplant clinics with unrelated hematopoietic steam cells (HSCs) is the lack of an interaction scheme “Registry — HSC collection center — Transplant center”. In order to ensure effective operation at the donor activation stage, registries need regulated and stable cooperation with the Collection center with a clear distribution of duties and responsibilities for both parties. Aim: to evaluate the effectiveness of the Kirov Registry.Materials and methods. Since 2009, the Kirov Registry has been systematically working with HSC donors (as of 25/11/2019, the total number of donors was 46,922, of which 43 % male, 57 % female; 49 % regular blood donors, 51 % volunteers from donor actions) since 2013. The Registry has its own Collection Center. The effectiveness of the Registry was evaluated by indicators: the number of donations, donor activation time, the number of refusals at the stages of preliminary activation and donation of cellular material. Results. As of 25/11/2019, more than 1,000 preliminary activations of potential HSC donors were performed, of which 175 were completed by collection of HSCs. The use of the created and validated activation model with the employment of the Registry and the Collection Center currently provides the following activation times: the period for sending a sample for confi rming HLA typing does not exceed 14 days; the total time to satisfy the transplant center request for cellular material does not exceed 2 months. A detailed analysis of the causes of refusals at the stages of preliminary activation and after receiving a request for the collection of cell material was carried out. Conclusion. Between 2009 and 2019 the Kirov registry has developed a model of effective work with the donors of the HSCs at all stages of the chain “Registry — HSC collection center — Transplant center”. The effectiveness of the work is confi rmed by the demand for donors, observance of the donor activation time, and a relatively low percentage of refusals from donations.

Distributions of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 alleles typed by next generation sequencing in Russian volunteer donors

“…HLA (HLA) genes play a central role in immunity and are responsible for graft rejection in HSCT 1–3 . The best compatible donor is a fully HLA‐identical sibling, but in Russia, only about 10%–20% of patients have such kind of donor 4,5 . For patients lacking a genotypically HLA‐matched sibling, an unrelated HSCT is proposed 6 …”

Accessibility to Join Bone Marrow Donor Registry for Volunteers

“…A register of potential donors of hematopoietic stem cells (HSCs) was organized based on the federal network of plasma centers of the Russian Medical Research and Production Center "Rosplasma" of the Federal Medical and Biological Agency (FMBA) of Russia, Kirov, in 2009. Recruitment of potential HSC donors was fulfilled in two main ways: working with regular plasma donors and holding mass actions in educational organizations, institutions and large enterprises [5].…”