Evaluation of the effects of total intravenous anesthesia and inhalation anesthesia on postoperative cognitive recovery

Karakurt, Tülay Ceren Ölmeztürk; Kuyrukluyıldız, Ufuk; Önk, Didem; Ünver, Süheyla; Arslan, Yusuf

doi:10.1007/s00101-021-01083-7

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…However, it requires hypnotics, inhalational anesthetics, opioids, muscle relaxants, sedatives, and cardiovascular drugs to maintain a constant state of unconsciousness in the aged. Inhaled and intravenous anesthetics ( Ölmeztürk Karakurt et al, 2022 ), benzodiazepines ( Marcantonio et al, 1994 ; Rudolph and Marcantonio, 2011 ), and opioids ( Dubois et al, 2001 ) are known or suspected risk factors for POD according to the available studies. Although perioperative opioid use is a risk factor for POD, it is difficult to avoid after major surgery because inadequate analgesia may increase the risk of POD ( Morrison et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis

Zhuang

Liu

et al. 2022

Front. Aging Neurosci.

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Study objectivePostoperative delirium (POD) is one of the serious postoperative complications in elderly patients, which is always related to long-term mortality. Anesthesia is often considered a risk factor for POD. This systematic review and network meta-analysis (NMA) aimed to assess the impact of different anesthesia methods and anesthetics on POD.MeasurementsWe searched for studies published in PubMed, Embase, Web of Science, Scopus, and Cochrane Library (CENTRAL) from inception to 18 March 2022. RevMan 5.3 and CINeMA 2.0.0 were used to assess the risk of bias and confidence. Data analysis using STATA 17.0 and R 4.1.2. STATA 17.0 was used to calculate the surface under the cumulative ranking curve (SUCRA) and provide network plots with CINeMA 2.0.0. NMA was performed with R 4.1.2 software gemtc packages in RStudio.Main resultsThis NMA included 19 RCTs with 5,406 patients. In the pairwise meta-analysis results, only regional anesthesia (RA) with general anesthesia (GA) vs. GA (Log OR: –1.08; 95% CI: –1.54, –0.63) were statistically different in POD incidence. In the NMA results, there was no statistical difference between anesthesia methods, and psoas compartment block (PCB) with bupivacaine was superior to the desflurane, propofol, sevoflurane, and spinal anesthesia with bupivacaine of POD occurrence.ConclusionOur study indicated that RA and GA had no significant effect on POD, and there was no difference between anesthesia methods. Pairwise meta-analysis showed that, except for RA with GA vs. GA, the rest of the results were not statistically different. Besides, PCB with bupivacaine may benefit to reduce POD incidence.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/dis play_record.php?ID=CRD42022319499, identifier PROSPERO 2022 CRD42022319499.

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Section: Introductionmentioning

confidence: 99%

The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis

Zhuang

Liu

et al. 2022

Front. Aging Neurosci.

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Intraoperative dexmedetomidine infusion might help to preserve the cognitive function of geriatric patients undergoing arthroscopic shoulder surgery

Helwa,

Saleh,

Elhennawy

2024

Egyptian Journal of Anaesthesia

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Drug Therapy of Cognitive Dysfunction in Minimally Invasive Surgery during Anesthesia with Sevoflurane

Неймарк

Shmelev

Rakhmonov

et al. 2022

Vestn. anesteziol. reanimatol.

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The objective: To conduct a comparative assessment of efficacy of Cytoflavin and Cellex for management of cognitive disorders after videolaparoscopic cholecystectomy performed under general inhalation anesthesia with sevoflurane.Results. In three representative groups (n = 30) of patients, markers of inflammation (CRP and IL-6), levels of brain-specific proteins (S-100 and NSE) were studied. Neuropsychological testing were performed by using the MoCA test, frontal dysfunction test battery (FAB) by two stages (stage I ‒ on the eve of the operation, stage II ‒ on the 7th day of the postoperative period). In patients of Group I (n = 30), disorders of higher mental functions of the early postoperative period persisted, which served as the basis for finding ways to eliminate and manage the identified disorders. For this purpose, Cytoflavin was used in Group II (n = 30), and Cellex was used in Group III (n = 30).Comparative characteristics of the level of brain-specific proteins revealed a statistically significant decrease at stage I in Groups II and III versus Group I. The lowest level of both NSE (by 1.45 μg/l, p = 0.041) and S-100 (by 10.1 ng/l, p = 0.044) was observed in Group III versus Group II. In addition, at the second stage of the study, the greatest severity of the inflammatory response was noted in Groups II and III of patients compared to Group I and this degree of severity could be potentiated by the ongoing drug therapy. If in Group I, disorders of higher mental functions persisted on the 7th day of the postoperative period, then as a result of the ongoing drug therapy in Groups II and III, it was possible to achieve significantly better results of neuropsychological testing.Conclusion. Administration of drug therapy contributed to the improvement of higher mental function eliminating cognitive deficit in the early postoperative period.

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Evaluation of the effects of total intravenous anesthesia and inhalation anesthesia on postoperative cognitive recovery

Cited by 3 publications

References 19 publications

The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis

The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis

Intraoperative dexmedetomidine infusion might help to preserve the cognitive function of geriatric patients undergoing arthroscopic shoulder surgery

Drug Therapy of Cognitive Dysfunction in Minimally Invasive Surgery during Anesthesia with Sevoflurane

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