Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes

Kotopoulis, Spiros; Haugsez, Ragnhild; Mujić, Maja; Sulen, André; Gullaksen, Stein-Erik; Cormack, Emmet Mc; Gilja, Odd Helge; Postema, Michiel; Gjertsen, Bjørn Tore

doi:10.1109/ultsym.2014.0292

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Medical diagnostic ultrasound has been used widely [1][2][3][4][5] since medical diagnostic ultrasound can give real-time image of the anatomical structures but it does not provide ionizing radiation such as X-ray. However, other possible biological effects associated with diagnostic ultrasound such as thermal or mechanical effects are a concern [6,7].…”

Section: Introductionmentioning

confidence: 99%

Calibration of ultrasonic hydrophone probes in the frequency range from 250 kHz to 1 MHz

Umchid

2015

2015 8th Biomedical Engineering International Conference (BMEiCON)

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Calibration of ultrasonic hydrophone probes in the frequency range from 250 kHz to 1 MHz is required to sufficiently assess the peak rarefactional pressure (p r ) and the Mechanical Index (MI) of medical ultrasound imaging devices. However, the ultrasonic hydrophone calibration in this low frequency is barely conducted. Therefore, the objective of this research was to develop a calibration technique for ultrasonic hydrophone probes in the frequency range from 250 kHz to 1 MHz. Two ultrasonic hydrophone probes, one membrane hydrophone and one needle hydrophone, were calibrated using a substitution method combined with time-delay spectrometry (TDS). The calibration results are presented in term of end-ofcable voltage sensitivity as a function of frequency. The calibration data show that the membrane hydrophone exhibit a very flat frequency response, to within ±1 dB for the entire investigated frequency range, whereas the needle hydrophone demonstrates a relative large variations in sensitivity of about 5 dB. These results are in good agreement with the limited data previously reported. Therefore, the substitution calibration technique with Time Delay Spectrometry (TDS) is capable of calibrating the ultrasonic hydrophone probes in the frequency range from 250 kHz to 1 MHz.

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