Evaluation of the Effects of Aqueous Leaves Extract of Cnestis ferruginea from Côte d’Ivoire on Male Rat Reproductive System

Ernest, Zougrou N’guessan; Aubin, Kouassi Kouadio; Tahiri, Abdelghani; Méa, Blahi Adélaïde Nadia; Kouakou, Koffi

doi:10.9734/ejmp/2018/43492

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Les paramètres spermatiques que sont la densité, la motilité et la morphologie sont considérés comme la clé de la fertilité chez le mâle. Dans l'étude menée par Zougrou et al, (2018b), les mâles traités avec l'extrait aqueux de C. ferruginea ont montré une augmentation significative des taux de spermatozoïdes mobiles, de leurs nombres et des spermatozoïdes normaux. Dans ce présent test de fertilité, les rats mâles traités avec la dose de 50 mg/kg de PC et croisés avec les femelles non traitées, ont tous engendré une gestation dont 66,67% ont occasionné 2 gestations.…”

Section: Discussionunclassified

Evaluation des Effets Fertilisants et Embryo-Toxiques de L’extrait Aqueux des Feuilles de Cnestis ferruginea Chez le Rat

Ernest

Marie-Odile

Méa

et al. 2019

ESJ

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The objective of this work is to evaluate the fertilization and embryotoxic effects of aqueous extract of Cnestis ferruginea in rats. First, 3 batches of rats (control, treated AECF50 and AECF100) were mated with untreated males. Then, 3 batches of male rats (control, treated AECF50 and AECF100) were mated with untreated females. Finally, two groups of rats, I (males) and II (females) were subdivided into three batches each (control, treated AECF50 and AECF100) and were mated according to the dose. The results showed 100% gestation in the treated females, but an increase in the post-implantation abortion rate with the AECF100. Regarding the test of treated males, the pregnancy, copulation and fertility rates were 75%, 83.33% and 100% for controls, AECF50 and AECF100, respectively. Pre-and post-implantation abortion rates decreased with both doses. The test of treated males mated with the treated females showed a pregnancy rate, a copulation index, and a 100% fertility index compared to controls (83.33%). For the uterine, fetal and placental weights, the extract induced a significant increase in the treated females. Histological studies of the ovary showed a significant increase in the diameter of the corpus luteum (35.14%) and the diameter of the uterine glands by 16.05% (AECF50) and 18.39% (AECF100). In conclusion, Cnestis ferruginea improves fertility in males and females. But, these positive effects can be hindered by high doses.

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Section: Discussionunclassified

Evaluation des Effets Fertilisants et Embryo-Toxiques de L’extrait Aqueux des Feuilles de Cnestis ferruginea Chez le Rat

Ernest

Marie-Odile

Méa

et al. 2019

ESJ

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“…The sperm were filmed with an AmScope camera (London, United Kingdom). Motile and immobile sperm were subsequently counted on 5 random fields and the percentage of motile forms was determined [22].…”

Section: Sperm Motilitymentioning

confidence: 99%

“…The resulting sections were stained in Harris haematoxylin and eosin solutions respectively. Mounting them using Eukitt allowed their good readability under a light microscope (Olympus CK41SF, Philippines) [22]. The installation of a camera connecting the microscope to a computer allowed image taking via AmScope 3.7 software (London, United Kingdom).…”

Section: Histological Studymentioning

confidence: 99%

“…Anti-diabetic activities of ethyl-acetate and methanol extracts of C. ferruginea leaves were demonstrated in an earlier experimental study [21]. Another study showed fertilizing effects of aqueous extract of C. ferruginea leaves in healthy wistar rats [22]. However, no study has yet shown that C. ferruginea leaves can both restore glycemic balance and correct hypofertility observed in diabetic subjects.…”

Section: Introductionmentioning

confidence: 96%

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Effects of the Aqueous Extract of Cnestis ferruginea Leaves on the Male Reproductive System in Alloxan-induced Diabetic Mice

Bégbin

Zougrou

Koffi

et al. 2021

EJMP

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Diabetes mellitus is the most common endocrine disease and one of the most common chronic disorders. Diabetes mellitus has been associated with impaired reproductive health, mainly in men. The present study aimed to evaluate effects of the aqueous extract of Cnestis ferruginea leaves on the male reproductive system in alloxan-induced diabetic mice. The determination of phenolic compounds content in the aqueous extract was performed by conventional methods. Diabetes was induced in adult male mice by intraperitoneal injection with a single dose of 220 mg/Kg body weight of alloxan. Animal’s treatment with 100 and 200 mg/Kg of body weight of the aqueous extract was started 34 days after induction of diabetes. Sperm density, morphology and motility were assessed by standard methods. Serum levels of testosterone, FSH, and LH were measured. In addition, the testes were removed for histological study. Proportions of total polyphenols, flavonoids and tannins in the aqueous extract of Cnestis ferruginea were 5260.32 +/- 26 mg EAG /100g, 1384.43 +/- 4 mg EQ /100g and 7380.95 +/- 121 mg EC /100g respectively. 100 and 200 mg/Kg of body weight doses induced highly significant (P ˂ .001) reductions of 68% and 71% in blood glucose levels respectively, significant (P ˂ .05) increases in testes weight of 9% and 10% respectively, highly significant (P ˂ .001) increases in testosterone, pituitary gonadotropins and sperm parameter levels. In addition, regeneration of seminiferous tubules and interstitial cells was observed. Cnestis ferruginea leaves are rich in phenolic compounds. These compounds have anti-diabetic and fertilizing activities on the male reproductive system of diabetic mice.

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Evaluation of the Effects of Aqueous Leaves Extract of Cnestis ferruginea from Côte d’Ivoire on Male Rat Reproductive System

Cited by 2 publications

References 14 publications

Evaluation des Effets Fertilisants et Embryo-Toxiques de L’extrait Aqueux des Feuilles de Cnestis ferruginea Chez le Rat

Evaluation des Effets Fertilisants et Embryo-Toxiques de L’extrait Aqueux des Feuilles de Cnestis ferruginea Chez le Rat

Effects of the Aqueous Extract of Cnestis ferruginea Leaves on the Male Reproductive System in Alloxan-induced Diabetic Mice

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