Evaluation of the effects of cross-linking and swelling on the mechanical behaviors of hydrogels using the digital image correlation method

Uchida, Makoto; Sengoku, Tatsuya; Kaneko, Yoshihisa; Okumura, Dai; Tanaka, Hiro; Ida, Shohei

doi:10.1039/c9sm00049f

Cited by 24 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observation showed that the decrease in the absorbance of MB release through the sample membrane may be due to the contraction of the microvoids formed between the polymeric chain. [12][13][14][15] Obtained experimental results illustrate that with an increasing cross-linking agent from 5 ml to 15 ml, absorbance of the prepared sample decreased from 0.426 to 0.422 in DMW and 0.474 to 0.419 in 0.1M HCl due to decrease in the pore diameter of the sample. Tables 4 and 5 determine the effect of MB release from the Ge-PEG composite hydrogel with varying amount of GE (2 g, 3 g, and 4 g) at a fixed amount of GA and PEG in the hydrogel compositions S.P -3, 6, and 7 in DMW and 0.1M HCl, respectively.…”

Section: Dye Released Studymentioning

confidence: 99%

Untitled

Iqubal¹

2020

AJP

View full text Add to dashboard Cite

Introduction: The main aim of the research was to determine the rate of release of dye from the hydrogels using spectrophotometer studies. Materials and Methods: The gelatin (GE)-polyethylene glycol (PEG) composite hydrogels were prepared by the simultaneous method. Several combinations of GE-PEG composite hydrogels were prepared with methylene blue (MB) dye in it. The components were thoroughly mixed by stirring the solution during preparation to make them homogeneous. Results and Discussion: The effects of glutaraldehyde, GE, and PEG variation on dye release with different hydrogel composition samples investigated. The results showed that as the concentration of cross-linking agent increases from 5 ml to 15 ml, absorbance of the sample decreased from 0.43 to 0.42 in demineralized water and 0.47 to 0.42 in 0.1M HCl due to decrease in the pore diameter of the sample, and with increased GE composition from 2.0 g to 4.0 g, absorbance of the sample also increased. Conclusion: The increased amount of GE decreased the intactness of the matrix, allowing the greater release of MB. The hydrophilic nature of PEG increases the interaction with the solvent which causes swelling of the microvoids, thus resulting in the high release of MB.

show abstract

Section: Dye Released Studymentioning

confidence: 99%

Untitled

Iqubal¹

2020

AJP

View full text Add to dashboard Cite

show abstract

“…IPN pore sizes and surface chemistries can also be controlled to tune the drug release kinetics, interaction between the hydrogel and the surrounding tissues along with its mechanical properties. [9,10]…”

Section: Original Articlementioning

confidence: 99%

“…Obtained experimental results illustrate that with increasing crosslinking agent from 5 ml to 15 ml, absorbance of the prepared sample decreased from 0.426 to 0.422 in DMW and 0.474 to 0.419 in 0.1 M HCl due to decrease in the pore diameter of the sample. [4,9,10] Effects of cross-linker variation on swelling behavior Table 2 determines the membrane swelling property due to the variation of cross-linker (5 ml, 10 ml, and 15 ml) in the hydrogel compositions S.P-3, 4, and 7 in DMW. The observation showed that the decrease in the swelling ratio of the sample membrane may be due to the contraction of the microvoids formed between the polymeric chains.…”

Section: Effects Of Cross-linker Variation On Dye Releasementioning

confidence: 99%

“…The observation showed that the decrease in the swelling ratio of the sample membrane may be due to the contraction of the microvoids formed between the polymeric chains. [4,9,10] Obtained experimental result illustrates that with increasing crosslinking agent from 5 ml to 15 ml, swelling ratio of the prepared sample decreased from 473.83 to 428.97 [ Table 2] in DMW due to the decrease in the pore diameter of the sample. Tables 3 and 4 determine the swelling behavior of compositions containing varying amount of gelatin (2 g, 3 g, and 4 g) at fixed GA and PEG in the hydrogel compositions S.P-3, 6, and 7 in DMW and 0.1 M HCl, respectively.…”

Section: Effects Of Cross-linker Variation On Dye Releasementioning

confidence: 99%

See 1 more Smart Citation

Untitled

Iqubal¹

2020

AJP

View full text Add to dashboard Cite

Introduction: The main objective of this study is to find the effects of cross-linker variation on swelling behavior of hydrogels at different temperatures, that is, 30 min-120 min. Hydrogels are three-dimensional cross-linked structural arrangement of the polymeric materials with the ability to absorb huge amounts of water while maintaining their dimensional stability. Materials and Methods: A solution of 20% glutaraldehyde (GA) was prepared in 100 ml standard flask by dissolving 20.0 g GA in a standard flask (of capacity 100 ml) and make up the volume up to the mark using demineralized water (DMW). The gelatin-polyethylene glycol (PEG) composite hydrogels were prepared by simultaneous method, in which all the constituent component networks are polymerized concurrently. Different combinations of gelatin-PEG composite hydrogels were prepared with methylene blue (MB) dye in it. Swelling was studied with the help of the following equation: d s s d W-W I = ×100 W Results and Discussion: The observation showed that the decrease in the absorbance of MB release through the sample membrane may be due to the contraction of the microvoids formed between the polymeric chains. Conclusion: Based on our results which conclude that with increasing crosslinking agent from 5 ml to 15 ml, swelling ratio of the prepared sample decreased from 473.83 to 428.97 in DMW due to the decrease in the pore diameter of the sample. As a result, more and more solvent diffuses into the matrix and produce gel with increased swelling ratio.

show abstract

“…Digital image correlation (DIC) is an established method in experimental biomechanics to obtain load-deformation properties such as elastic modulus (E mod ), ultimate tensile strength (UTS) or strain at maximum force (SF max ) of biological tissues based on surface deformation when the tissues are loaded and subsequently deformed [1][2][3][4][5] . In the case of non-homogenous and anisotropic materials, DIC enables for accurate contactless measurements at a reasonable cost-benefit ratio compared to other techniques such as holographic interferometry, electronic speckle pattern interferometry or Moiré interferometry 6 .…”

mentioning

confidence: 99%

Surface coating and speckling of the human iliotibial tract does not affect its load-deformation properties

Zwirner

Ondruschka

Scholze

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Stochastic surface patterns form an important requirement to facilitate digital image correlation and to subsequently quantify material properties of various tissues when loaded and deformed without artefacts arising from material slippage. Depending on the samples’ natural colour, a surface pattern is created by speckling with colour or dye only, or it requires combined surface coating and speckling before to enhance the contrast, to facilitate high-quality data recording for mechanical evaluation. However, it is unclear to date if the colours deployed for coating and speckling do significantly alter the biomechanical properties of soft tissues. The given study investigated the biomechanical properties of 168 human iliotibial tract samples as a model for collagen-rich soft tissues, separated into four groups: untreated, graphite speckling only, water-based coating plus graphite speckling and solvent-based coating plus graphite speckling following a standardized approach of application and data acquisition. The results reveal that elastic modulus, ultimate tensile strength and strain at maximum force of all groups were similar and statistically non-different (p ≥ 0.69). Qualitatively, the speckle patterns revealed increasing contrast differences in the following order: untreated, graphite speckling only, water-based coating plus graphite speckling and solvent-based coating plus graphite speckling. Conclusively, both coating by water- and solvent-based paints, as well as exclusive graphite speckling, did not significantly influence the load-deformation parameters of the here used human iliotibial tract as a model for collagen-rich soft tissues. In consequence, water- and solvent-based coating paints seem equally suitable to coat collagen-rich soft tissues for digital image correlation, resulting in suitable speckle patterns and unbiased data acquisition.

show abstract

Evaluation of the effects of cross-linking and swelling on the mechanical behaviors of hydrogels using the digital image correlation method

Abstract: The effects of cross-linking and swelling on the true stress–strain response of hydrogel were evaluated using DIC, and the mechanical response was fitted based on a non-Gaussian statistical model.

Cited by 24 publications

References 23 publications

Untitled

Untitled

Untitled

Surface coating and speckling of the human iliotibial tract does not affect its load-deformation properties

Contact Info

Product

Resources

About