Evaluation of the effects of antioxidant treatment on sperm parameters and pregnancy rates in infertile patients after varicocelectomy: a randomized controlled trial

Kızılay, Fuat; Altay, Barış

doi:10.1038/s41443-018-0109-4

Cited by 28 publications

(30 citation statements)

References 29 publications

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“…Among the remaining 17 studies, nine studies were excluded for lack of useful data and another two studies because they were identical studies describing the same indicators. Finally, six articles (Azizollahi et al, ; Cyrus, Kabir, Goodarzi, & Moghimi, ; Ener et al, ; Kizilay & Altay, ; Lu, Liu, Li, Yang, & Zhang, ; Nematollahi‐Mahani, Azizollahi, Baneshi, Safari, & Azizollahi, ) comparing sperm outcomes between antioxidant therapy and placebo therapy after varicocelectomy were included in our study (Figure describes the search process in detail). The baseline characteristics of these six studies are summarised in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (Azizollahi et al, ; Kizilay & Altay, ) included four comparisons (antioxidants vs. placebo; zinc sulphate and folic acid vs. placebo; folic acid vs. placebo; and zinc sulphate vs. placebo) and were analysed for changes in progressive sperm motility. A random‐effects model for 202 patients (149 in the antioxidant therapy group and 53 in the placebo group) revealed high heterogeneity ( I 2 = 93%, p < .00001) and an MD of −1.66 (95% CI: −5.15 to 2.83, p = .57); There was no significant difference between the two groups (Figure b).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (Azizollahi et al, ; Kizilay & Altay, ) including 203 patients were evaluated (149 in the antioxidant therapy group and 54 in the placebo group; Figure b). Four comparisons (antioxidants vs. placebo; zinc sulphate and folic acid vs. placebo; folic acid vs. placebo; and zinc sulphate vs. placebo) were evaluated using a fixed‐effects model, which revealed significant improvements in sperm morphology in the antioxidant group (MD 0.58, 95% CI: 0.47–0.69, p < .00001).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of antioxidant therapy on sperm quality measurements after varicocelectomy: A systematic review and meta‐analysis

Wang

Ding

et al. 2019

Andrologia

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Antioxidants were proved to be efficient to improve the quality of spermatozoa after varicocelectomy. We carried out a systematic review and performed a meta‐analysis to evaluate the efficacy of antioxidant therapy in sperm parameters' quality after varicocelectomy during 3 or 6 months' treatment cycle. During research, randomised controlled trials were searched by MEDLINE, EMBASE and the Cochrane Controlled Trials Register, and necessary parameters were compared between two groups after varicocelectomy. Finally, six studies including 576 patients were included in our meta‐analysis. As for sperm parameters, significant improvements of sperm concentration (p < .0001), sperm motility (p = .03), progressive sperm motility (p < .00001) and sperm morphology (p < .00001) were existed in antioxidant group 3 months after varicocelectomy. With regard to the 6 months' outcomes, sperm parameters were improved as well except sperm motility (p = .72) and progressive sperm motility (p = .57). Referring to pregnancy rate, no significant difference was existed between two groups (p = .36), and the FSH level of antioxidant group was lower than placebo group 3 or 6 months after varicocelectomy (3 months, p = .02; 6 months, p = .03). In conclusion, compared with the placebo, the antioxidant therapy after varicocelectomy can improve the quality of sperm parameters and construct a favourable living condition for spermatozoa by reducing FSH level.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of antioxidant therapy on sperm quality measurements after varicocelectomy: A systematic review and meta‐analysis

Wang

Ding

et al. 2019

Andrologia

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“…Kombine tedavi alan grupta klinik gebelik oranlarının daha yüksek olduğu bildirilmiştir. [55] Randomize kontrollü çalışmalardan elde edilen bir metaanalize göre varikoselektomi sonrası adjuvan tamamlayıcı tedavi alan grupta klinik gebelik oranlarında anlamlı bir değişiklik görülmez iken antioksidanlar ile 3. ay sperm motilite ve sperm DNA bütünlüğünde anlamlı artış olduğu bildirilmiştir.…”

Section: Erkek İnferti̇li̇tesi̇nde Vari̇koselektomi̇ Sonrasi Tamamlayici Tunclassified

Erkek infertilitesi ve erektil disfonksiyon tedavisinde tamamlayıcı tıp: Moleküler düzeyde etki mekanizmaları ve klinik sonuçlar

Can¹,

Canat²

2020

Androl Bul

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“…Infertility is a serious health problem, affecting nearly 15% of couples throughout the world and described as being unable to conceive despite engaging regular sexual intercourse for one year (8). Conventional treatments usually result in a serious physical and economic burden.…”

Section: Introductionmentioning

confidence: 99%

Effect of The Opopanax Hispidus Plant's Aerial Parts Extract on Mice Ovary

Çölçimen¹,

Arıhan²,

Gümüşok³

et al. 2020

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Amaç: Opopanax hispidus bitkisi Apiaceae familyasındandır. Tedavi amaçlı yaygın olarak hemoroid, kadın infertilitesi ve kanın temizlenmesinde kullanılmaktadır. Çalışmamızda Opopanax hispidus metanolik gövde ekstresini farelere vererek over dokusu üzerinde oluşturduğu histolojik değişiklikleri incelemeyi amaçladık. Gereçler ve Yöntem: 12 adet erişkin, dişi, Swiss-Albino fare alındı, randomize olarak 2 gruba ayrıldı. Kontrol grubu: Herhangi bir uygulama yapılmadı. Opopanax hispidus grubu: Opopanax hispidus metanolik ekstresi (200 mg/kg/gün) 5 gün oral gavajla uygulandı. Deneyin sonunda, sağ over dokusu eksize edilerek çıkarıldı. Dokular %10'luk tamponlu formaldehit içinde fikse edildi, rutin histolojik inceleme için takip metodları uygulandı ve akabinde 5 µm kalınlığında kesitler alındı. Kesitler hematoksilen-eozin ile boyandı ve ışık mikroskopik incelemeye tabii tutuldu. Stereolojik ölçümde Cavalieri prensibinin modifiye metodu kullanıldı. Total doku volüm oranları, Shtereom 1.5 version paket programında verilmiş noktalı alan cetveliyle ölçüldü. Grupların karşılaştırılmasında Mann-Whitney U testi kullanıldı. Hesaplamalarda, istatistik anlamlılık düzeyi %5 alındı. Tüm hesaplamalar için SPSS (ver:20) istatistik paket programı kullanıldı. Bulgular: Antral follikül sayısı açısından değerlendirildiğinde istatistiki olarak anlamlı fark bulundu (p<0.05). Gruplar arasında over volümü değerlendirildiğinde Opopanax hispidus grubunda kontrol grubuna göre azalma olduğu ve istatistiki olarak anlamlı olduğu tesbit edildi (p<0.05). Sonuç: Opopanax hispidus' un over dokusunda olumlu etkiler oluşturarak antral follikül sayısını arttırdığını tesbit ettik ve bu artışın muhtemelen antioksidan etkisinden kaynaklandığını düşünmekteyiz.

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Evaluation of the effects of antioxidant treatment on sperm parameters and pregnancy rates in infertile patients after varicocelectomy: a randomized controlled trial

Cited by 28 publications

References 29 publications

Efficacy of antioxidant therapy on sperm quality measurements after varicocelectomy: A systematic review and meta‐analysis

Efficacy of antioxidant therapy on sperm quality measurements after varicocelectomy: A systematic review and meta‐analysis

Erkek infertilitesi ve erektil disfonksiyon tedavisinde tamamlayıcı tıp: Moleküler düzeyde etki mekanizmaları ve klinik sonuçlar

Effect of The Opopanax Hispidus Plant's Aerial Parts Extract on Mice Ovary

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