Evaluation of the effects of chitin nanofibrils on skin function using skin models

Ito, Ikuko; Osaki, Tomohiro; Ifuku, Shinsuke; Saimoto, Hiroyuki; Takamori, Yoshimori; Kurozumi, Seizi; Imagawa, Tomohiro; Aso, Kazuo; Tsuka, Takeshi; Okamoto, Yoshiharu; Minami, Saburo

doi:10.1016/j.carbpol.2013.09.074

Cited by 49 publications

(38 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, they have anti-inflammatory actions via the suppression of NF-κB and MCP-1 activations and they suppress fibrosis in an acute ulcerative colitis mouse model, indicating that chitin NF is potentially a novel medicine or functional food for patients with inflammatory bowel disease [69,70]. Furthermore, the application of chitin NF to skin improved the epithelial granular layer, increased granular density, and resulted in lower production of TGF-β, indicating that chitin NFs can be incorporated into the manufacture of cosmetics or textiles [71,72]. Consequently, we expect that chitin NF with the above-mentioned properties will be widely used as a novel bio-material in the near future.…”

Section: Discussionmentioning

confidence: 99%

Chitin and Chitosan Nanofibers: Preparation and Chemical Modifications

2014

Self Cite

View full text Add to dashboard Cite

Chitin nanofibers are prepared from the exoskeletons of crabs and prawns, squid pens and mushrooms by a simple mechanical treatment after a series of purification steps. The nanofibers have fine nanofiber networks with a uniform width of approximately 10 nm. The method used for chitin-nanofiber isolation is also successfully applied to the cell walls of mushrooms. Commercial chitin and chitosan powders are also easily converted into nanofibers by mechanical treatment, since these powders consist of nanofiber aggregates. Grinders and high-pressure waterjet systems are effective for disintegrating chitin into nanofibers. Acidic conditions are the key factor to facilitate mechanical fibrillation. Surface modification is an effective way to change the surface property and to endow nanofiber surface with other properties. Several modifications to the chitin NF surface are achieved,

show abstract

Section: Discussionmentioning

confidence: 99%

Chitin and Chitosan Nanofibers: Preparation and Chemical Modifications

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, it has anti-inflammatory actions via the suppression of NF-B and MCP-1 activations, and it suppresses fibrosis (Azuma et al, 2012a,b). Furthermore, the application of nanochitin to skin improved the epithelial granular layer, increased granular density, and resulted in lower production of TGF-␤ (Ito et al, 2014). Consequently, chitin nanofibrils has broad potential for medical applications Azuma, Ifuku, Osaki, Okamoto, & Minami, 2014).…”

Section: Introductionmentioning

confidence: 99%

Preparation of zwitterionically charged nanocrystals by surface TEMPO-mediated oxidation and partial deacetylation of α-chitin

Ifuku

Hori

Izawa

et al. 2015

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

“…For instance, they have anti-inflammatory actions via the suppression of NF-B and MCP-1 activations and suppress fibrosis in an acute ulcerative colitis mouse model [18,19]. Furthermore, the application of chitin NF to skin improved the epithelial granular layer, increased granular density, and reduced production of TGF-␤ [20,21].…”

Section: Introductionmentioning

confidence: 99%