Evaluation of the Effects of Clerodendrum polycephalum Baker Leaf Extracts on Sickle Red Blood Cells

Isolation and In Vitro and In Vivo Activity of Secondary Metabolites from Clerodendrum polycephalum Baker against Plasmodium Malaria Parasites

“…9,11,12 Modern pharmacological research on C. polycephalum has also been documented. 6,7,10,12 Given its traditional usage to treat malaria-like symptoms, Adewoyin and co-workers conducted an in vivo antiplasmodial examination of the leaf extracts from this species in Plasmodium berghei-infected mice. 12 In a 4-day Peter's suppressive model, 13 oral administration of the extract showed ∼87−92% attenuation of blood-stage parasitemia using 200−600 mg/kg extract compared to ∼75% attenuation of parasitemia for the control drug chloroquine (10 mg/kg).…”

“…Clerodendrum polycephalum Baker is a flowering plant which can be found in tropical regions of Africa, South Asia, Cameroon, Ghana, Sierra Leone, and Guinea. , Little information is available regarding the chemistry of C. polycephalum , with only a few studies on the detection of its general constituents such as carbohydrates, tannins, flavonoids, alkaloids, saponins, and essential oil. , However, the plant is well known for its ethnomedical applications. For example, in parts of Western Africa, the leaf sap of C. polycephalum has been used to treat epileptic attacks, giddiness, and fainting. , Native healers use an infusion of the leaves as an antidote for snake venom and other venomous stings. , A powder or paste of the root, stem, and leaves as well as their extracts are utilized in treating asthma, cataracts, and diseases of the blood, skin, and lungs. , Decoction of the leaves is employed to treat malaria-like symptoms, bacterial wound infection, pain, and bleeding from cuts in Southwestern regions of Nigeria. ,, …”

“…For example, in parts of Western Africa, the leaf sap of C. polycephalum has been used to treat epileptic attacks, giddiness, and fainting. 9,10 Native healers use an infusion of the leaves as an antidote for snake venom and other venomous stings. 8,11 A powder or paste of the root, stem, and leaves as well as their extracts are utilized in treating asthma, cataracts, and diseases of the blood, skin, and lungs.…”

“…8,11 A powder or paste of the root, stem, and leaves as well as their extracts are utilized in treating asthma, cataracts, and diseases of the blood, skin, and lungs. 10,11 Decoction of the leaves is employed to treat malaria-like symptoms, bacterial wound infection, pain, and bleeding from cuts in Southwestern regions of Nigeria. 9,11,12 Modern pharmacological research on C. polycephalum has also been documented.…”