Evaluation of the Effectiveness of Silver-Modified Monthmorillonitis in Treatment of Patients with Skin and Soft

Al-Kanani, Edres S.; Shevchenko, Ekaterina G.; Gostishev, Viktor K.; Yarosh, A L; Karpachev, Aleksandr A.; Солошенко, А. В.; Olejnik, N V; Bondarenko, Nadezhda Nikolaevna

doi:10.52575/2687-0940-2022-45-3-302-314

Актуальные Проблемы Медицины

2022

DOI: 10.52575/2687-0940-2022-45-3-302-314

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Evaluation of the Effectiveness of Silver-Modified Monthmorillonitis in Treatment of Patients with Skin and Soft

Edres S. Al-Kanani

Ekaterina G. Shevchenko

Viktor K. Gostishev

et al.

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2024

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Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Terekhov,

Mishina,

Klyueva

et al. 2024

Innovacionnaâ medicina Kubani

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Objective: To study peculiarities of skin wound healing under ischemic conditions with topical treatment using a combination of benzalkonium chloride and dexpanthenol.Materials and methods: We conducted an experiment on a rat model of skin wound healing under ischemic conditions. Male Wistar rats were divided into 4 groups, with 30 rats in each group. Group 1 received no treatment; group 2 was treated with the Levomecol ointment; group 3 and group 4 were treated with benzalkonium chloride immobilized based on the carboxymethylcellulose sodium salt and a combination of benzalkonium chloride and dexpanthenol immobilized based on the carboxymethylcellulose sodium salt, respectively. We used planimetric and biochemical (alkaline phosphatase [ALP] level) methods, measured the pH of the wound surface and wound bed temperature, determined the hydroxyproline concentration in the wound defect tissues, and performed statistical processing of the data.Results: Group 4 had the largest percentage of wound surface area reduction and pH values. Thermometry on day 10 showed a decrease in wound temperature in groups 2 and 4, whereas groups 1 and 3 demonstrated maximum values. By the end of the experiment, group 4 had the maximum hydroxyproline concentration that was significantly higher than the amino acid content in groups 1, 2, and 3: 1.2, 1.1 and 1.1 times higher, respectively. Maximum ALP levels were observed on day 5 in group 4, whereas in groups 2 and 3 they were observed on day 8 and only on day 10 in group 1.Conclusions: Skin wound healing under ischemic conditions was faster in the group in which topical treatment involved a combination developed by us: benzalkonium chloride and dexpanthenol immobilized based on the carboxymethylcellulose sodium salt.

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Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Terekhov,

Mishina,

Klyueva

et al. 2024

Innovacionnaâ medicina Kubani

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show abstract

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Evaluation of the Effectiveness of Silver-Modified Monthmorillonitis in Treatment of Patients with Skin and Soft

Cited by 1 publication

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Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

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