Evaluation of the effectiveness of novel single-intervention adaptive radiotherapy strategies based on daily dose accumulation

Ciarmatori, A.; Maffei, N.; Mistretta, G.M.; Ceroni, P.; Bernabei, Annalisa; Meduri, Bruno; D’Angelo, Elisa; Bruni, Alessio; Giacobazzi, Pierluigi; Lohr, Frank; Guidi, G.

doi:10.1016/j.meddos.2019.02.002

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Daily dose accumulation based on DIR of scan-CT with the kV plan-CT maybe a novel strategy. 19 Poon et al 20 proposed an efficient tool to registrar CBCT with planning CT by DIR to stimulate the actual accumulated dose distributions. The greatest percentage difference in observed dose parameters of target was less than 5%.…”

Section: Discussionmentioning

confidence: 99%

Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy

Yao

et al. 2023

Technol Cancer Res Treat

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Background To analyze the relationship between the rotational and residual setup errors and the dose deviation on nasopharyngeal carcinoma (NPC) treated by helical tomotherapy (HT). Methods From 25 July 2017 to 20 August 2019, 16 treated NPC patients were enrolled in the study. These patients were scanned with full target range megavoltage computed tomography (MVCT) every other day. Adaptive radiotherapy function application software MIM7.1.3 were used to accumulate the actual dose. The dose deviation with the initial plan dose of the patients’ target and organs at risk (OAR) were compared, and the correlation between the dose change and the setup errors (rotational setup errors and neck residual setup error) was analyzed. Results Translational setup errors increased farther away from the head. Statistically significant difference among 3 groups was achieved in the directions of left-right ( P < .001) and anteroposterior ( P < .001) by analysis of variance test. Compared with the initial plan dose, the actual accumulated dose of the target area decreased with the actual exposure dose of the OAR increased. However, most of the dosimetric parameters differed by less than 5%. No correlation was found between dose deviation values and the translational setup errors of target. However, sagittal rotational setup errors (pitch) had a positive relationship ( P < .05) with the avearge dose of PTVnd (L) ( r = 0.885), PTVnd(R) ( r = 0.547) PTV1( r = 0.633) and PTV2( r = 0.584). Transverse rotational setup errors (roll) had a positive relationship ( P < .05) with the avearge dose of PTVnd(R) ( r = 0.593), PTV1( r = 0.505) and PTV2( r = 0.662). Conclusions Dose deviation between the actual accumulated and initial plan is not negligible, but most indicators difference is less than 5%, NPC patients treated by HT with MVCT correction setup errors every other day did not need adaptive radiotherapy model unless got rapid tumor shrinkage or weight loss. Moreover, to minimize the dose deviation, more attention should be paid to the reduction of pitch, roll, and residual error of cervical vertebrae during body positioning.

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Section: Discussionmentioning

confidence: 99%

Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy

Yao

et al. 2023

Technol Cancer Res Treat

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“…Consequently, it is feasible to perform dosimetric corrections in subsequent fractions based on the previously delivered dose (Yan et al 1999, Wu et al 2006, de la Zerda et al 2007, Jaffray et al 2010. Furthermore, plan adaptation typically aims at preserving the goals of the initial treatment plan but adaptation can be used in the context of adapted dose escalation and local boosts (Weiss et al 2013, Hafeez et al 2016, Ciarmatori et al 2019.…”

Section: Introductionmentioning

confidence: 99%

Adaptive proton therapy

et al. 2021

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Radiation therapy treatments are typically planned based on a single image set, assuming that the patient’s anatomy and its position relative to the delivery system remains constant during the course of treatment. Similarly, the prescription dose assumes constant biological dose-response over the treatment course. However, variations can and do occur on multiple time scales. For treatment sites with significant intra-fractional motion, geometric changes happen over seconds or minutes, while biological considerations change over days or weeks. At an intermediate timescale, geometric changes occur between daily treatment fractions. Adaptive radiation therapy is applied to consider changes in patient anatomy during the course of fractionated treatment delivery. While traditionally adaptation has been done off-line with replanning based on new CT images, online treatment adaptation based on on-board imaging has gained momentum in recent years due to advanced imaging techniques combined with treatment delivery systems. Adaptation is particularly important in proton therapy where small changes in patient anatomy can lead to significant dose perturbations due to the dose conformality and finite range of proton beams. This review summarizes the current state-of-the-art of on-line adaptive proton therapy and identifies areas requiring further research.

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Multimodal imaging in radiotherapy: Focus on adaptive therapy and quality control

Talbot

Devos

Dubus

et al. 2020

Cancer/Radiothérapie

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Evaluation of the effectiveness of novel single-intervention adaptive radiotherapy strategies based on daily dose accumulation

Cited by 5 publications

References 24 publications

Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy

Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy

Adaptive proton therapy

Multimodal imaging in radiotherapy: Focus on adaptive therapy and quality control

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