Evaluation of the Effectiveness of 5% Potassium Hydroxide for the Treatment of Molluscum contagiosum

Romiti, Ricardo; Ribeiro, Alessandra P.; Romiti, Ney

doi:10.1046/j.1525-1470.2000.01837-7.x

Cited by 50 publications

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“…7 More recently we have demonstrated the efficacy and safety profile of the use of potassium hydroxide (KOH) 5 to 10% in aqueous solution, in the treatment of molluscum contagious in immunocompetent children. [8][9][10] The solution must be applied at home by the patient or parents through the use of a swab on each lesion. The applications should be repeated daily until there are signs of erythema or local edema.…”

Section: Discussionmentioning

confidence: 99%

Molusco contagioso em tatuagem

Molina¹,

Romiti

2011

An. Bras. Dermatol.

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Molluscum contagiosum is a disease caused by a poxvirus characterized by benign self-limited eruption of single or multiple cutaneous spherical and pearly papules. Transmission usually occurs by direct contact with infected hosts. It is reported the case of a 22-year-old Caucasian male who presented characteristic pearly and umbilicated papules strictly located on the region of a tattoo. Histopathologic exam confirmed the diagnosis of molluscum contagiosum. The authors describe an uncommomn manifestation of dissemination of this virus in tattoos and also present a literature review emphasizing the transmission pathways and treatment of Molluscum contagiosum. Keywords: Molluscum Contagiosum; Poxviridae Infections; Tattoo Resumo: Molusco contagioso é uma dermatovirose causada por poxvírus e caracterizada por erupção benigna e autolimitada de uma ou múltiplas pápulas esféricas e brilhantes. A transmissão habitualmente ocorre por contato direto com indivíduos infectados. Relata-se caso de doente masculino, 22 anos, com história de surgimento de numerosas pápulas umbilicadas localizadas estritamente sobre a região de uma tatuagem. Exame histopatológico de uma das pápulas confirmou a hipótese clínica de molusco contagioso. Os autores descrevem uma manifestação pouco frequente da disseminação desse vírus em tatuagens e apresentam uma revisão da literatura, enfatizando as vias de transmissão e a terapêutica do molusco contagioso.

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Section: Discussionmentioning

confidence: 99%

Molusco contagioso em tatuagem

Molina¹,

Romiti

2011

An. Bras. Dermatol.

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“…Romiti et al also reported a study in which patients were instructed to apply 5% KOH solution, which was done in an attempt to reduce the side effects observed with higher concentration. 7 They found 5% KOH as effective and less irritating when compared to KOH 10%. 7 Both of the study treatment regimens have advantage over other treatment options as they are locally applicable, less traumatic and painful.…”

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confidence: 98%

“…7 They found 5% KOH as effective and less irritating when compared to KOH 10%. 7 Both of the study treatment regimens have advantage over other treatment options as they are locally applicable, less traumatic and painful. Because of these characteristics, they can be easily applicable for the treatment of Mollascum Contagiosum.…”

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Comparative Study of 5 % Potassium Hydroxide Solution Versus 0.05% Tretinoin Cream for Molluscum Contagiosum in Children

Rajouria

Amatya

Karn

2012

Kathmandu Univ. Med. J.

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BackgroundMolluscum contagiosum is one of the commonest cutaneous viral infections in children. All treatment modalities are associated with substantial pain, tissue destruction, and frequent recurrence. ObjectivesTo compare the efficacy and side effects of KOH 5% solution with tretinoin 0.05% cream for the treatment of molluscum contagiosum in children. MethodsFifty patients were randomly divided into 2 groups; 25 each for 5% KOH solution and 0.05% tretinoin cream. The given medication was applied at bed time over molluscum lesions. The assessment of response and side effects were performed weekly for 4 weeks. ResultsAt the end of 4 weeks, the mean lesion count decreased from 9.48±3.00 SD to 1.67±0.58 SD and from 8.35±2.82 SD to 2.00±1.00 SD in patients treated with 5% KOH solution and 0.05% tretinoin cream respectively. ConclusionThe result of both KOH and tretinoin showed good response, well tolerated by children but between the two, KOH showed fast recovery and most lesions were resolved before 4 week. The side effects could be minimized if applied as stated above. On the other hand, tretinoin showed delayed response and even some of lesion extended beyond 4 week but the side effect were less, and hence can be used in recurrent cases.

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“…The only defect of KOH treatment was local side effects which included a stinging sensation around the site of application, and hyper-or hypopigmentation. For this rea- son they had tried 5% KOH solution and consequently had less irritation 12 .…”

Section: Discussionmentioning

confidence: 99%

An Open, Randomized, Comparative Clinical and Histological Study of Imiquimod 5% Cream Versus 10% Potassium Hydroxide Solution in the Treatment of Molluscum Contagiosum

et al. 2010

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Background: Although molluscum contagiosum (MC) resolves spontaneously, there are several reasons to treat this dermatological disorder. Objective: To evaluate the safety and efficacy of 5% imiquimod cream versus 10% potassium hydroxide (KOH) solution in treating MC, and to propose the mechanism of cure by observing the histological findings. Methods: Imiquimod or KOH were applied by the patient or a parent 3 days per week until all lesions cleared. The number of MC lesions was counted and side effects were evaluated at 5 points during the treatment (the initial visit, week 2, week 4, week 8, and week 12). Histological changes were compared between 2 patients of each group, before and after the 2 weeks of application. Results: In both group, the mean lesion counts decreased all through to week 12, and the reduction in number of lesions were statistically significant in both groups (p＜0.005). Over 40% of each group developed local side effects, and no systemic side effects were noted in either group. Before treatment, histological findings showed little or no dermal infiltrates. After treatment, specimens showed dense lymphocytic infiltrates, especially T cells, around the lesions which had resolved. Conclusion: Both 10% KOH solution and 5% imiquimod cream are effective and safe treatment of MC.

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Evaluation of the Effectiveness of 5% Potassium Hydroxide for the Treatment of Molluscum contagiosum

Cited by 50 publications

References 1 publication

Molusco contagioso em tatuagem

Molusco contagioso em tatuagem

Comparative Study of 5 % Potassium Hydroxide Solution Versus 0.05% Tretinoin Cream for Molluscum Contagiosum in Children

An Open, Randomized, Comparative Clinical and Histological Study of Imiquimod 5% Cream Versus 10% Potassium Hydroxide Solution in the Treatment of Molluscum Contagiosum

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