Evaluation of the effectiveness of maternal immunization against pertussis in Alberta using agent-based modeling: A Canadian immunization research network study

Hempel, Karsten; McDonald, Wade; Osgood, Nathaniel D.; Fisman, David N.; Halperin, Scott A.; Crowcroft, Natasha S.; Klein, Nicola P.; Rohani, Pejman; Doroshenko, Alexander

doi:10.1016/j.vaccine.2022.12.071

Cited by 1 publication

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 64 articles that described potentially relevant infectious disease models. We then selected the four models (9)(10)(11)(12) used in the analysis based on the following criteria: 1) model was available and adaptable; 2) Canada-specific (with preference given to those that were Alberta-focused); 3) included the vaccines of interest; 4) time horizon of the analysis; 5) year of study; 6) stratification of the results (e.g., age groups, sex, health risk factors); and 7) health outcomes captured.…”

Section: Identification Of Peer Reviewed Disease Models and Immunizat...mentioning

confidence: 99%

See 1 more Smart Citation

Optimization of an adult immunization program in Canada

Locke,

Paulden,

MacDonald

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundProvincial decisions to fund a new immunization program are generally made on a case-by-case basis, without systematic consideration of how the new immunization program may fit within the larger provincial immunization portfolio.AimThe goal of this study was to develop evidence and tools to guide policy-makers in making fiscally and ethically responsible decisions on which adult immunization programs to include in their portfolio under various constrained budgetary scenarios.MethodsUsing previously published infectious disease models, cost-utility data was estimated for adult pneumococcal, influenza, pertussis, and shingles immunization programs. This data was then inputted into a newly developed constrained optimization model to determine portfolios of immunization programs that maximize either population health or incremental net monetary benefit, subject to a budget constraint. Sensitivity analyses were conducted on model parameters such as vaccine costs, cost-effectiveness thresholds, and the budget constraint.ResultsOptimized solutions changed dramatically based on the number of immunization programs included, total budget, what was optimized for (i.e., population health or incremental net monetary benefit), the cost-effectiveness threshold and the assumed vaccine prices. Maximal health gains and budget spending was achieved when optimizing based on population health. Reductions in health gains and budget spending were observed at a CAN$50,000 cost-effectiveness threshold, and at a CAN$30,000 threshold, the budget was significantly underutilized and health gains were noticeably reduced.ConclusionIf budgets for the adult immunization portfolio are fixed, then shifting to more expensive programs that offer large health benefits may be preferable. However, if budgets can be spread across various public health programs (i.e., childhood immunization, well-baby programs), it may make more sense to optimize based on cost-effectiveness. Constrained optimization tools could improve goals-based decision-making and allow for transparent and effective methods to make allocation decisions.HighlightsOptimized solutions changed dramatically based on the number of immunization programs available, total budget, and the cost-effectiveness threshold.If budgets for the adult immunization portfolio are fixed, then shifting to more expensive programs that offer large health benefits may be preferable.If budgets can be spread across various public health programs, it may make more sense to optimize based on cost-effectiveness.Constrained optimization tools could improve goals-based decision-making and allow for transparent and effective methods to make allocation decisions.

show abstract

Section: Identification Of Peer Reviewed Disease Models and Immunizat...mentioning

confidence: 99%

“…Our analysis looks at two age cohorts, where vaccination was provided at age 50 or 65. For pertussis, we used an agent-based model developed byHempel et al (2023)(12) that included maternal vaccination against pertussis. The model is a stochastic dynamic infectious disease model that estimates pertussis cases across 1-year age increments between 0 and 99.…”

mentioning

confidence: 99%

Optimization of an adult immunization program in Canada

Locke,

Paulden,

MacDonald

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Evaluation of the effectiveness of maternal immunization against pertussis in Alberta using agent-based modeling: A Canadian immunization research network study

Cited by 1 publication

References 43 publications

Optimization of an adult immunization program in Canada

Optimization of an adult immunization program in Canada

Contact Info

Product

Resources

About