Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity

Motlagh, Parisa Esmaili; Novin, Arefeh Ghafari; Ghahari, Fatemeh; Nikzad, Amin; Khoshandam, Mohadeseh; Mardani, Saba; Khanbabaei, Hashem; Farsinejad, Alireza; Sathyapalan, Thozhukat; Sahebkar, Amirhossein; Pourghadamyari, Hossein

doi:10.1007/978-3-030-73234-9_10

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…The use of natural products in combination with chemotherapeutic agents to reduce side effects is a novel approach, and several studies have shown promising results (Motlagh et al, 2021). This in vivo study and its findings indicate that carotenoids extracted from pumpkin may be a promising cardioprotective agent against doxorubicin induced cardiotoxicity, at least in part mediated through inhibition of DOX-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 70%

Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

et al. 2023

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Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study we compared the cardioprotective effect of a mixture of pumpkin carotenoids and a commercially available antioxidant preparation. Animals were distributed in 8 groups (Control -S; NADES -N; Doxorubicin -Dox; Carotenoids -Car; CardiofortIN -CF; NADES-Doxorubicin -N-Dox; Carotenoids-Doxorubicin -Car-Dox; CardiofortIN-Doxorubicin -CF-Dox). Histological sections were stained with the hematoxylin-eosin (HE) and analyzed for the presence of myocardial damage by doxorubicin damage score (DDS). From the heart tissue homogenate were determined the intensity of lipid peroxidation and specific antioxidative enzyme activity (superoxide dismutase; catalase; glutathione S-transferase; glutathione peroxidase). In Car-DOX and CF-DOX groups, lipid peroxidation is significantly reduced compared to DOX group. Pretreatment of animals with carotenoids and in lesser extent with CardiofortIN led to higher antioxidative enzymes activity, compared to DOX group. Pretreated with carotenoids, only 50 % of animals had some degree of myocardial damage, and no animals had extensive damage. CardiofortIN pretreatment showed less protective effect. Pretreatment with carotenoid extract, reduced DDS significantly, so Car-DOX group has changes equivalent to mild myocardial damage. Although CardiofortIN pretreatment lowered DDS score values, animals still had moderate level of myocardium damage. This in vivo study and its findings indicate that carotenoids extracted from pumpkin may be a promising cardioprotective agent against doxorubicin induced cardiotoxicity, at least in part mediated through inhibition of DOX-induced oxidative stress.

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Section: Discussionmentioning

confidence: 70%

Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

et al. 2023

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“…In the study conducted by Chu et al, Cr was found to have a protective effect on DOX-induced cardiotoxicity both in vitro and in vivo (26). Motlaqh et al reported the protective effects of Cr on DOX-induced cardiotoxicity (27).…”

Section: Discussionmentioning

confidence: 98%

Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats

Shekarriz

Galedari

Nikbakht³

et al. 2022

Jentashapir J Cell Mol Biol

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Background: Doxorubicin (DOX) is widely used to treat various cancers, but its cardio-toxicity restricts its therapeutic application. Objectives: This study aimed to investigate the effect of 8 weeks of continuous aerobic training (CAT) and administration of crocin (Cr) on the apoptotic index and the expression of Bax and Bcl-2 genes on the DOX-induced cardio-toxicity of rats. Methods: In this experimental study, 50 male Wistar rats were randomly divided into 5 groups, including control, DOX, DOX + CAT, DOX + Cr, and DOX + CAT + Cr groups. Continuous aerobic training consisted of 60 minutes of running with the intensity of 40% - 60% of maximum speed (5 days/week). Apoptotic index and the expression levels of Bax and Bcl-2 genes were determined in the heart tissue. Results: Doxorubicin significantly increased Bax gene expression in the heart tissue of animals (P < 0.001). In contrast, Bcl-2 gene expression significantly decreased (P < 0.001). In all experimental groups, the Bax/Bcl-2 ratio and the percentage of the terminal deoxynucleotidal transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells were significantly diminished compared to the DOX-intoxicated animals. Among experimental groups, CAT had more antiapoptotic effects against DOX-induced cardiac toxicity. Conclusions: Continuous aerobic training and Cr, alone or in combination, could attenuate DOX-induced cardiotoxicity by suppressing apoptosis in the rats.

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“…Ker Gawl root (SOJ) increased SOD, CAT, and GSH-Px activities and decreased MDA in rat myocardial tissue by inhibiting OS ( 70 ). In H9C2 cells, XML decrease DOX-induced MDA content, enhance SOD activity, increase ROS scavenging, and attenuate cardiotoxicity ( 71 ); RES reduced DOX-induced ROS content and improved cell survival, the effect of RES against DOX cardiotoxicity was comparable to that of dexrazoxane and carvedilol ( 72 ); additionally, crocin can reduce ROS, MDA and total oxidant status (TOS) levels, increase total antioxidant capacity (TAC), mitigation of DNA damage ( 73 ).…”

Section: Molecular Mechanisms Of Chemoradiotherapy-related Cardiotoxi...mentioning

confidence: 99%

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

Wen

et al. 2022

Front. Cardiovasc. Med.

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Cardiotoxicity is a serious complication of cancer therapy. It is the second leading cause of morbidity and mortality in cancer survivors and is associated with a variety of factors, including oxidative stress, inflammation, apoptosis, autophagy, endoplasmic reticulum stress, and abnormal myocardial energy metabolism. A number of studies have shown that traditional Chinese medicine (TCM) can mitigate chemoradiotherapy-associated cardiotoxicity via these pathways. Therefore, this study reviews the effects and molecular mechanisms of TCM on chemoradiotherapy-related cardiotoxicity. In this study, we searched PubMed for basic studies on the anti-cardiotoxicity of TCM in the past 5 years and summarized their results. Angelica Sinensis, Astragalus membranaceus Bunge, Danshinone IIA sulfonate sodium (STS), Astragaloside (AS), Resveratrol, Ginsenoside, Quercetin, Danggui Buxue Decoction (DBD), Shengxian decoction (SXT), Compound Danshen Dripping Pill (CDDP), Qishen Huanwu Capsule (QSHWC), Angelica Sinensis and Astragalus membranaceus Bunge Ultrafiltration Extract (AS-AM),Shenmai injection (SMI), Xinmailong (XML), and nearly 60 other herbs, herbal monomers, herbal soups and herbal compound preparations were found to be effective as complementary or alternative treatments. These preparations reduced chemoradiotherapy-induced cardiotoxicity through various pathways such as anti-oxidative stress, anti-inflammation, alleviating endoplasmic reticulum stress, regulation of apoptosis and autophagy, and improvement of myocardial energy metabolism. However, few clinical trials have been conducted on these therapies, and these trials can provide stronger evidence-based support for TCM.

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Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity

Cited by 7 publications

References 35 publications

Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

Protective Effect of Continuous Aerobic Training and Crocin on Doxorubicin-Induced Apoptosis in the Heart Tissue of Rats

Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

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