Evaluation of the Effect of Platelet-Rich Fibrin on Wound Healing at Split-Thickness Skin Graft Donor Sites: A Randomized, Placebo-Controlled, Triple-Blind Study

Abstract

Split-thickness skin grafting (STSG) is widely used to heal wounds resulting from trauma, burns, and chronic wounds. This study aimed to determine the true effect of platelet-rich fibrin (PRF) on patients with burn wounds requiring STSG during treatment of donor wounds. This randomized, triple-blind clinical trial was conducted on patients who referred to the burn ward of Vasei Hospital of Sabzevar, Iran, from May 2017 to May 2018. The donor site was randomly divided into 2 groups: PRF and control (Vaseline petrolatum gauze) using Vaseline gauze. In the intervention group, the PRF gel was applied to the wound and covered with Vaseline gauze and wet dressing. Conversely, only Vaseline gauze and wet dressing were applied to the control group. Outcome evaluation was conducted using paired t test and Wilcoxon signed rank-sum test, as appropriate, on days 8 and 15. The mean age of the patients was 33.10 ± 2.60 years, and 51.50% were male. The mean wound healing time in the PRF and control groups was 11.80 ± 3.51 and 16.30 ± 4.32 days, respectively ( P < .001). The PRF group showed significantly higher wound healing rates than the control group at 8 and 15 days dressing ( P < .001 and P < .001, respectively). Moreover, the mean wound healing for all wound healing indices diagnosed by 2 specialists in PRF was higher than control group on days 8 and 15 ( P < .001). We found a statistically significant difference on days 8 and 15 regarding the mean pain levels between the 2 groups ( P < .001). The findings showed that PRF can significantly increase the time and rate of donor wound healing compared with conventional treatment and also reduce the severity of pain.

Autologous Matrix of Platelet-Rich Fibrin in Wound Care Settings: A Systematic Review of Randomized Clinical Trials

“…In the individual internal validation of the included studies, for the domain selection of bias, seven studies were classified as low risk of bias [ 29 , 30 , 31 , 34 , 35 , 38 ], three studies as the uncertain risk of bias [ 33 , 36 , 37 ], and one study as high risk of bias [ 32 ].…”

“…For the fourth evaluated domain, frictional bias, all studies were classified as low risk of bias. Finally, for the domain reporting bias, five studies were classified as low risk of bias [ 31 , 34 , 35 , 36 , 37 ], and five as high risk of bias [ 29 , 30 , 32 , 33 , 38 ].…”

“…In the critical evaluation of the studies regarding allocation secrecy, two studies were allocated to Category A [ 34 , 38 ], because they adequately described the allocation process; eight studies were allocated to Category B [ 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 ] because they did not report the allocation process of the groups effectively; however, they described the randomization process of the participants; one study allocated participants inadequately, being designated to Category C [ 32 ]. Therefore, no study was allocated to Category D. However, the majority of studies did not declare the way the randomization of individuals was carried out for the intervention and control groups in the right manner.…”

Pengaruh Platelet Rich Fibrin Pada Proses Epitelisasi Luka Donor Skin Graft: Studi Meta Analisis

“…Tempat donor bisa menjadi bekas luka sekunder yang sering menyakitkan, yang mungkin membutuhkan waktu lebih lama pulih dari transplantasi dan dapat meningkatkan risiko infeksi dan jaringan parut. 2 Komorbiditas, termasuk penuaan, malnutrisi, tidak aktif, merokok, diabetes, dan vaskular penyakit, dapat menyebabkan gangguan penyembuhan luka donor (Vaheb, et al, 2020 sebagai subjek penelitian mereka. FGG merupakan prosedur yang sering digunakan untuk meningkatkan perluasan gingiva, karena hasil pembedahannya mudah ditebak dan sederhana teknik dan aplikasi di area operasi yang luas.…”

Sweet Readers Love the Spring

“…Three further works explore innovations in chronic wound healing. 4-6 In rats, Bilgic 7 has studied the efficacy of local and systemic resveratrol in wound healing.…”